SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gde'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)
3gde DNA LIGASE
(Archaeoglobus
fulgidus)
4 / 8 SER A 253
VAL A 255
SER A 268
ASP A 530
None
1.02A 1hwiB-3gdeA:
undetectable
1hwiB-3gdeA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)
3gde DNA LIGASE
(Archaeoglobus
fulgidus)
4 / 8 SER A 253
VAL A 255
SER A 268
ASP A 530
None
1.08A 1hwkA-3gdeA:
undetectable
1hwkA-3gdeA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)
3gde DNA LIGASE
(Archaeoglobus
fulgidus)
4 / 8 SER A 253
VAL A 255
SER A 268
ASP A 530
None
1.07A 1hwkC-3gdeA:
undetectable
1hwkC-3gdeA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)
3gde DNA LIGASE
(Archaeoglobus
fulgidus)
4 / 8 SER A 253
VAL A 255
SER A 268
ASP A 530
None
1.06A 1hwkD-3gdeA:
undetectable
1hwkD-3gdeA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)
3gde DNA LIGASE
(Archaeoglobus
fulgidus)
5 / 12 GLY A  64
LEU A 160
ILE A 159
ILE A 137
LEU A 140
None
1.14A 1kyvA-3gdeA:
undetectable
1kyvE-3gdeA:
undetectable
1kyvA-3gdeA:
14.84
1kyvE-3gdeA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)
3gde DNA LIGASE
(Archaeoglobus
fulgidus)
5 / 12 ILE A 137
LEU A 140
GLY A  64
LEU A 160
ILE A 159
None
1.16A 1kyvB-3gdeA:
undetectable
1kyvC-3gdeA:
undetectable
1kyvB-3gdeA:
14.84
1kyvC-3gdeA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)
3gde DNA LIGASE
(Archaeoglobus
fulgidus)
5 / 11 THR A 265
ILE A 266
THR A 275
ILE A 285
VAL A 282
None
1.05A 1pkvA-3gdeA:
undetectable
1pkvB-3gdeA:
undetectable
1pkvA-3gdeA:
10.63
1pkvB-3gdeA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)
3gde DNA LIGASE
(Archaeoglobus
fulgidus)
5 / 11 ILE A 285
VAL A 282
THR A 265
ILE A 266
THR A 275
None
1.05A 1pkvA-3gdeA:
undetectable
1pkvB-3gdeA:
undetectable
1pkvA-3gdeA:
10.63
1pkvB-3gdeA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)
3gde DNA LIGASE
(Archaeoglobus
fulgidus)
4 / 7 ARG A 118
PHE A  45
TYR A  51
ILE A 124
None
1.19A 1tdnA-3gdeA:
undetectable
1tdnA-3gdeA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)
3gde DNA LIGASE
(Archaeoglobus
fulgidus)
4 / 8 ARG A 224
ASN A 273
SER A 268
ARG A 270
None
None
None
PO4  A 556 ( 4.8A)
1.23A 1u1jA-3gdeA:
undetectable
1u1jA-3gdeA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)
3gde DNA LIGASE
(Archaeoglobus
fulgidus)
4 / 8 PHE A 310
ARG A 270
LEU A 314
ASP A 537
None
PO4  A 556 ( 4.8A)
None
None
1.15A 2bxkA-3gdeA:
2.1
2bxkA-3gdeA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)
3gde DNA LIGASE
(Archaeoglobus
fulgidus)
4 / 6 GLY A 431
PHE A 494
PRO A 496
LYS A 497
None
1.06A 2m2oB-3gdeA:
undetectable
2m2oB-3gdeA:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)
3gde DNA LIGASE
(Archaeoglobus
fulgidus)
4 / 8 ASP A 296
MET A 225
GLU A 247
GLU A 298
None
1.36A 3dh0A-3gdeA:
undetectable
3dh0A-3gdeA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)
3gde DNA LIGASE
(Archaeoglobus
fulgidus)
4 / 6 VAL A  76
SER A  83
LEU A 160
LEU A  98
None
0.95A 3kk6A-3gdeA:
undetectable
3kk6A-3gdeA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)
3gde DNA LIGASE
(Archaeoglobus
fulgidus)
4 / 8 ILE A  99
ALA A 108
THR A 106
VAL A  73
None
0.87A 3me6B-3gdeA:
undetectable
3me6B-3gdeA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_A_ADNA501_1
(DNA LIGASE)
3gde DNA LIGASE
(Archaeoglobus
fulgidus)
6 / 12 GLU A 247
LYS A 249
GLU A 298
PHE A 337
LYS A 400
LYS A 417
None
PO4  A 557 (-2.7A)
None
None
None
PO4  A 556 ( 2.5A)
0.89A 3qwuA-3gdeA:
10.8
3qwuA-3gdeA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_B_ADNB501_1
(DNA LIGASE)
3gde DNA LIGASE
(Archaeoglobus
fulgidus)
5 / 11 GLU A 247
LYS A 249
GLU A 298
PHE A 337
LYS A 400
None
PO4  A 557 (-2.7A)
None
None
None
0.73A 3qwuB-3gdeA:
6.2
3qwuB-3gdeA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
3gde DNA LIGASE
(Archaeoglobus
fulgidus)
3 / 3 LYS A 417
ARG A 270
LEU A 227
PO4  A 556 ( 2.5A)
PO4  A 556 ( 4.8A)
PO4  A 556 ( 4.5A)
1.41A 3v4tE-3gdeA:
undetectable
3v4tE-3gdeA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
3gde DNA LIGASE
(Archaeoglobus
fulgidus)
3 / 3 LYS A 384
GLU A 388
TRP A 248
None
1.27A 3v4tH-3gdeA:
undetectable
3v4tH-3gdeA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)
3gde DNA LIGASE
(Archaeoglobus
fulgidus)
3 / 3 ARG A 411
ASP A 296
GLN A 256
PO4  A 556 (-2.9A)
None
None
0.92A 4azsA-3gdeA:
undetectable
4azsA-3gdeA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)
3gde DNA LIGASE
(Archaeoglobus
fulgidus)
4 / 7 LEU A  70
TYR A 144
ILE A 159
GLY A  64
None
0.87A 4eq4A-3gdeA:
undetectable
4eq4A-3gdeA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)
3gde DNA LIGASE
(Archaeoglobus
fulgidus)
4 / 8 LEU A  70
TYR A 144
ILE A 159
GLY A  64
None
0.88A 4eq4B-3gdeA:
undetectable
4eq4B-3gdeA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)
3gde DNA LIGASE
(Archaeoglobus
fulgidus)
4 / 7 LEU A  70
TYR A 144
ILE A 159
GLY A  64
None
0.85A 4eqlA-3gdeA:
undetectable
4eqlA-3gdeA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)
3gde DNA LIGASE
(Archaeoglobus
fulgidus)
4 / 7 LEU A  70
TYR A 144
ILE A 159
GLY A  64
None
0.86A 4eqlB-3gdeA:
undetectable
4eqlB-3gdeA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)
3gde DNA LIGASE
(Archaeoglobus
fulgidus)
5 / 11 ILE A 266
LEU A 271
ASP A 296
GLY A 297
TYR A 406
None
1.41A 4foxF-3gdeA:
undetectable
4foxF-3gdeA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)
3gde DNA LIGASE
(Archaeoglobus
fulgidus)
4 / 7 ASP A 534
THR A  47
ASN A 195
LEU A 271
None
1.13A 4ib4A-3gdeA:
undetectable
4ib4A-3gdeA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)
3gde DNA LIGASE
(Archaeoglobus
fulgidus)
4 / 6 LEU A  70
TYR A 144
ILE A 159
GLY A  64
None
0.87A 4l39A-3gdeA:
undetectable
4l39A-3gdeA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)
3gde DNA LIGASE
(Archaeoglobus
fulgidus)
4 / 7 LEU A  70
TYR A 144
ILE A 159
GLY A  64
None
0.81A 4l39B-3gdeA:
undetectable
4l39B-3gdeA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)
3gde DNA LIGASE
(Archaeoglobus
fulgidus)
4 / 8 ARG A 254
ASP A 338
SER A 404
TYR A 406
None
0.94A 4lv9A-3gdeA:
undetectable
4lv9B-3gdeA:
undetectable
4lv9A-3gdeA:
23.85
4lv9B-3gdeA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
3gde DNA LIGASE
(Archaeoglobus
fulgidus)
4 / 5 ILE A  63
LEU A  66
GLU A  82
VAL A  76
None
0.97A 4nkxB-3gdeA:
undetectable
4nkxB-3gdeA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3gde DNA LIGASE
(Archaeoglobus
fulgidus)
4 / 5 ILE A 193
VAL A 223
PHE A 336
CYH A 346
None
1.14A 4rzvA-3gdeA:
undetectable
4rzvA-3gdeA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)
3gde DNA LIGASE
(Archaeoglobus
fulgidus)
5 / 12 SER A  74
LEU A  70
ALA A  95
LEU A 155
ALA A  69
None
1.20A 4x1kA-3gdeA:
undetectable
4x1kB-3gdeA:
undetectable
4x1kA-3gdeA:
21.71
4x1kB-3gdeA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)
3gde DNA LIGASE
(Archaeoglobus
fulgidus)
4 / 5 ARG A 520
ARG A 463
GLY A 462
GLU A 447
None
1.27A 4z3oA-3gdeA:
undetectable
4z3oB-3gdeA:
undetectable
4z3oA-3gdeA:
21.53
4z3oB-3gdeA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)
3gde DNA LIGASE
(Archaeoglobus
fulgidus)
4 / 6 ILE A 407
PRO A 408
HIS A 258
ILE A 339
None
0.85A 4zj8A-3gdeA:
undetectable
4zj8A-3gdeA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)
3gde DNA LIGASE
(Archaeoglobus
fulgidus)
4 / 6 ILE A 193
ARG A 199
ILE A 221
GLU A 218
None
1.27A 4zzcA-3gdeA:
undetectable
4zzcB-3gdeA:
undetectable
4zzcA-3gdeA:
20.53
4zzcB-3gdeA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)
3gde DNA LIGASE
(Archaeoglobus
fulgidus)
4 / 4 LEU A 295
ILE A 285
GLY A 297
ILE A 281
None
0.88A 5dzk3-3gdeA:
undetectable
5dzkm-3gdeA:
undetectable
5dzk3-3gdeA:
2.90
5dzkm-3gdeA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)
3gde DNA LIGASE
(Archaeoglobus
fulgidus)
4 / 5 PHE A 336
ILE A 281
GLY A 297
ILE A 285
None
0.82A 5dzkB-3gdeA:
undetectable
5dzkI-3gdeA:
undetectable
5dzkW-3gdeA:
undetectable
5dzkB-3gdeA:
16.73
5dzkI-3gdeA:
16.67
5dzkW-3gdeA:
2.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
3gde DNA LIGASE
(Archaeoglobus
fulgidus)
5 / 12 GLU A 471
PHE A 494
ILE A 484
PHE A 446
GLY A 432
None
1.39A 5esgA-3gdeA:
undetectable
5esgA-3gdeA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)
3gde DNA LIGASE
(Archaeoglobus
fulgidus)
4 / 8 ARG A 526
PRO A 309
GLY A 252
ASP A 251
PO4  A 559 (-3.7A)
None
None
None
1.16A 5kf8A-3gdeA:
undetectable
5kf8A-3gdeA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)
3gde DNA LIGASE
(Archaeoglobus
fulgidus)
5 / 12 THR A 156
LEU A  13
PHE A 121
PHE A   6
PHE A   3
None
1.02A 6a93A-3gdeA:
undetectable
6a93A-3gdeA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9H_R_ADNR400_1
(CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1)
3gde DNA LIGASE
(Archaeoglobus
fulgidus)
5 / 10 VAL A 117
THR A 120
PHE A  45
LEU A  59
ILE A 159
None
1.29A 6d9hR-3gdeA:
undetectable
6d9hR-3gdeA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)
3gde DNA LIGASE
(Archaeoglobus
fulgidus)
5 / 8 LYS A 205
ALA A 204
GLY A 211
LEU A 212
ALA A 190
None
1.36A 6mdqA-3gdeA:
undetectable
6mdqA-3gdeA:
11.16