SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gdh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 3gdh TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		3 / 3 TRP A 648
VAL A 641
TRP A 669
 None
 1.29A 1c4dA-3gdhA:
undetectable
1c4dB-3gdhA:
undetectable		 1c4dA-3gdhA:
8.16
1c4dB-3gdhA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 3gdh TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		5 / 12 GLY A 700
ILE A 720
ASP A 721
ASP A 747
PRO A 765
 SAH  A 854 (-3.3A)
SAH  A 854 (-3.6A)
None
SAH  A 854 (-3.6A)
SAH  A 854 (-3.8A)
 0.63A 1qaoA-3gdhA:
11.5		 1qaoA-3gdhA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 3gdh TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		6 / 12 GLY A 702
GLY A 703
ILE A 720
ASP A 721
ASP A 747
PRO A 765
 SAH  A 854 (-4.4A)
SAH  A 854 (-3.0A)
SAH  A 854 (-3.6A)
None
SAH  A 854 (-3.6A)
SAH  A 854 (-3.8A)
 0.68A 1sqfA-3gdhA:
13.5		 1sqfA-3gdhA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 3gdh TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		5 / 11 THR A 673
ILE A 720
ASP A 721
ASP A 747
PRO A 765
 SAH  A 854 (-4.5A)
SAH  A 854 (-3.6A)
None
SAH  A 854 (-3.6A)
SAH  A 854 (-3.8A)
 1.13A 2admA-3gdhA:
10.6		 2admA-3gdhA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 3gdh TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		3 / 3 ALA A 682
THR A 711
PHE A 761
 None
 0.63A 2c6nB-3gdhA:
undetectable		 2c6nB-3gdhA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 3gdh TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		5 / 12 PHE A 698
GLY A 700
GLY A 702
ASP A 747
PRO A 765
 SAH  A 854 (-4.3A)
SAH  A 854 (-3.3A)
SAH  A 854 (-4.4A)
SAH  A 854 (-3.6A)
SAH  A 854 (-3.8A)
 0.91A 2dpmA-3gdhA:
11.2		 2dpmA-3gdhA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 3gdh TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		5 / 12 GLY A 700
GLY A 703
ASP A 721
ASP A 747
PRO A 765
 SAH  A 854 (-3.3A)
SAH  A 854 (-3.0A)
None
SAH  A 854 (-3.6A)
SAH  A 854 (-3.8A)
 0.76A 2hmyB-3gdhA:
8.3		 2hmyB-3gdhA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 3gdh TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		5 / 12 PHE A 698
GLY A 700
GLY A 703
ASP A 721
PRO A 765
 SAH  A 854 (-4.3A)
SAH  A 854 (-3.3A)
SAH  A 854 (-3.0A)
None
SAH  A 854 (-3.8A)
 0.70A 2hmyB-3gdhA:
8.3		 2hmyB-3gdhA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 3gdh TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		4 / 8 LEU A 755
LEU A 751
PHE A 748
PHE A 698
 None
None
None
SAH  A 854 (-4.3A)
 0.92A 2vctC-3gdhA:
undetectable		 2vctC-3gdhA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3gdh TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		5 / 10 PHE A 698
GLY A 700
ASP A 719
ILE A 720
ASP A 747
 SAH  A 854 (-4.3A)
SAH  A 854 (-3.3A)
SAH  A 854 (-2.9A)
SAH  A 854 (-3.6A)
SAH  A 854 (-3.6A)
 0.36A 3ay0B-3gdhA:
9.1		 3ay0B-3gdhA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 3gdh TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		5 / 12 PHE A 698
GLY A 703
ASP A 721
ASP A 747
PRO A 765
 SAH  A 854 (-4.3A)
SAH  A 854 (-3.0A)
None
SAH  A 854 (-3.6A)
SAH  A 854 (-3.8A)
 0.54A 3eeoA-3gdhA:
9.9		 3eeoA-3gdhA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN201_1
(PROTEIN S100-A4)		 3gdh TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		5 / 10 PHE A 842
GLY A 843
GLY A 819
ILE A 826
PHE A 761
 None
 1.44A 3ko0L-3gdhA:
undetectable
3ko0N-3gdhA:
undetectable		 3ko0L-3gdhA:
17.86
3ko0N-3gdhA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3gdh TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		3 / 3 GLY A 700
ASP A 719
ASP A 747
 SAH  A 854 (-3.3A)
SAH  A 854 (-2.9A)
SAH  A 854 (-3.6A)
 0.41A 3ou7C-3gdhA:
12.0		 3ou7C-3gdhA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 3gdh TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		5 / 11 GLY A 700
ASP A 719
ASP A 721
ASP A 747
PRO A 765
 SAH  A 854 (-3.3A)
SAH  A 854 (-2.9A)
None
SAH  A 854 (-3.6A)
SAH  A 854 (-3.8A)
 0.66A 3v8vB-3gdhA:
15.3		 3v8vB-3gdhA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AMJ_B_CVDB1360_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3gdh TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		5 / 12 LEU A 817
VAL A 685
PHE A 761
PHE A 708
ASN A 704
 None
None
None
None
SAH  A 854 (-4.0A)
 1.38A 4amjB-3gdhA:
undetectable		 4amjB-3gdhA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 3gdh TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		4 / 7 ILE A 790
PHE A 698
LEU A 749
ASP A 747
 None
SAH  A 854 (-4.3A)
SAH  A 854 ( 4.9A)
SAH  A 854 (-3.6A)
 1.10A 4mmcA-3gdhA:
undetectable		 4mmcA-3gdhA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3gdh TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		5 / 12 PHE A 698
GLY A 700
ASP A 719
ILE A 720
PRO A 765
 SAH  A 854 (-4.3A)
SAH  A 854 (-3.3A)
SAH  A 854 (-2.9A)
SAH  A 854 (-3.6A)
SAH  A 854 (-3.8A)
 0.50A 4rtsA-3gdhA:
12.3		 4rtsA-3gdhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3gdh TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		4 / 5 ILE A 790
PHE A 754
SER A 763
ASP A 747
 None
None
SAH  A 854 ( 2.7A)
SAH  A 854 (-3.6A)
 1.26A 4rzvB-3gdhA:
undetectable		 4rzvB-3gdhA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 3gdh TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		4 / 4 ASP A 696
GLY A 700
ASP A 719
ASP A 747
 None
SAH  A 854 (-3.3A)
SAH  A 854 (-2.9A)
SAH  A 854 (-3.6A)
 0.43A 5e72A-3gdhA:
17.5		 5e72A-3gdhA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 3gdh TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		5 / 11 PHE A 698
GLY A 700
ILE A 720
ASP A 747
PRO A 765
 SAH  A 854 (-4.3A)
SAH  A 854 (-3.3A)
SAH  A 854 (-3.6A)
SAH  A 854 (-3.6A)
SAH  A 854 (-3.8A)
 0.82A 5hjiA-3gdhA:
14.4		 5hjiA-3gdhA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 3gdh TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens) 		5 / 12 PHE A 698
GLY A 700
GLY A 703
ASP A 721
ASP A 747
 SAH  A 854 (-4.3A)
SAH  A 854 (-3.3A)
SAH  A 854 (-3.0A)
None
SAH  A 854 (-3.6A)
 0.60A 6mhtA-3gdhA:
9.2		 6mhtA-3gdhA:
22.61