SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gdw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 3gdw SIGMA-54 INTERACTION
DOMAIN PROTEIN
(Enterococcus
faecalis) 		5 / 9 ILE A 645
ILE A 640
GLU A 643
ALA A 644
THR A 636
 None
 1.30A 2dtjA-3gdwA:
undetectable
2dtjB-3gdwA:
undetectable		 2dtjA-3gdwA:
19.55
2dtjB-3gdwA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 3gdw SIGMA-54 INTERACTION
DOMAIN PROTEIN
(Enterococcus
faecalis) 		3 / 3 MET A 635
VAL A 547
GLU A 643
 None
 0.79A 2x9gA-3gdwA:
2.8		 2x9gA-3gdwA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3gdw SIGMA-54 INTERACTION
DOMAIN PROTEIN
(Enterococcus
faecalis) 		5 / 5 LEU A 622
LEU A 602
GLY A 546
GLY A 605
THR A 630
 None
 1.29A 3si7C-3gdwA:
undetectable
3si7D-3gdwA:
undetectable		 3si7C-3gdwA:
21.38
3si7D-3gdwA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 3gdw SIGMA-54 INTERACTION
DOMAIN PROTEIN
(Enterococcus
faecalis) 		5 / 12 ILE A 657
THR A 626
LEU A 654
LEU A 591
LEU A 608
 None
 1.20A 4qynB-3gdwA:
undetectable		 4qynB-3gdwA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3gdw SIGMA-54 INTERACTION
DOMAIN PROTEIN
(Enterococcus
faecalis) 		4 / 7 THR A 563
LEU A 567
THR A 638
LEU A 642
 None
 0.88A 4z90A-3gdwA:
undetectable
4z90B-3gdwA:
undetectable
4z90C-3gdwA:
undetectable
4z90D-3gdwA:
undetectable
4z90E-3gdwA:
undetectable		 4z90A-3gdwA:
21.72
4z90B-3gdwA:
21.72
4z90C-3gdwA:
21.72
4z90D-3gdwA:
21.72
4z90E-3gdwA:
21.72