SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gdz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3gdz ARGINYL-TRNA
SYNTHETASE
(Klebsiella
pneumoniae) 		5 / 10 ALA A  48
ASN A  42
ALA A  41
ILE A  83
LEU A  63
 None
EDO  A 107 ( 3.2A)
None
None
None
 1.08A 3fl9F-3gdzA:
undetectable		 3fl9F-3gdzA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3gdz ARGINYL-TRNA
SYNTHETASE
(Klebsiella
pneumoniae) 		4 / 8 ASP A  88
ILE A  71
LYS A  10
ILE A  85
 EDO  A 109 ( 3.1A)
None
None
None
 0.87A 4kttB-3gdzA:
undetectable		 4kttB-3gdzA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3gdz ARGINYL-TRNA
SYNTHETASE
(Klebsiella
pneumoniae) 		4 / 8 ASP A  88
ILE A  71
LYS A  10
ILE A  85
 EDO  A 109 ( 3.1A)
None
None
None
 0.86A 4ndnB-3gdzA:
undetectable		 4ndnB-3gdzA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_1
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 3gdz ARGINYL-TRNA
SYNTHETASE
(Klebsiella
pneumoniae) 		4 / 5 SER A  31
GLU A  76
ASP A  38
ASN A  73
 None
None
None
EDO  A 109 ( 3.5A)
 1.25A 4pclA-3gdzA:
undetectable		 4pclA-3gdzA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 3gdz ARGINYL-TRNA
SYNTHETASE
(Klebsiella
pneumoniae) 		4 / 5 VAL A  75
ASN A  69
ASP A  67
LEU A  68
 None
EDO  A 109 ( 4.6A)
None
None
 1.29A 5m0iB-3gdzA:
undetectable		 5m0iB-3gdzA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3gdz ARGINYL-TRNA
SYNTHETASE
(Klebsiella
pneumoniae) 		3 / 3 VAL A  28
TYR A  39
GLN A  40
 None
None
EDO  A 107 ( 2.9A)
 0.59A 5qgkA-3gdzA:
undetectable		 5qgkA-3gdzA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3gdz ARGINYL-TRNA
SYNTHETASE
(Klebsiella
pneumoniae) 		3 / 3 VAL A  28
TYR A  39
GLN A  40
 None
None
EDO  A 107 ( 2.9A)
 0.57A 5qgrA-3gdzA:
undetectable		 5qgrA-3gdzA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3gdz ARGINYL-TRNA
SYNTHETASE
(Klebsiella
pneumoniae) 		3 / 3 VAL A  28
TYR A  39
GLN A  40
 None
None
EDO  A 107 ( 2.9A)
 0.61A 5qgtA-3gdzA:
undetectable		 5qgtA-3gdzA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3gdz ARGINYL-TRNA
SYNTHETASE
(Klebsiella
pneumoniae) 		5 / 10 VAL A  11
LEU A   7
GLY A  37
GLN A  40
VAL A  75
 None
None
None
EDO  A 107 ( 2.9A)
None
 1.27A 6czmE-3gdzA:
undetectable
6czmF-3gdzA:
2.7		 6czmE-3gdzA:
14.49
6czmF-3gdzA:
14.49