SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ge4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 3ge4 DNA PROTECTION
DURING STARVATION
PROTEIN
(Brucella
melitensis) 		5 / 12 ARG A 126
SER A 128
LEU A  66
LEU A 155
ASP A 152
 None
 1.35A 1e7wA-3ge4A:
undetectable		 1e7wA-3ge4A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 3ge4 DNA PROTECTION
DURING STARVATION
PROTEIN
(Brucella
melitensis) 		5 / 11 GLY A  86
ILE A  23
LEU A  26
ALA A  74
ALA A  77
 None
 0.94A 1x7pA-3ge4A:
undetectable
1x7pB-3ge4A:
undetectable		 1x7pA-3ge4A:
21.99
1x7pB-3ge4A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3ge4 DNA PROTECTION
DURING STARVATION
PROTEIN
(Brucella
melitensis) 		4 / 6 GLU A  94
GLU A  28
ALA A  31
ASN A  27
 None
 1.05A 3pgyA-3ge4A:
undetectable
3pgyB-3ge4A:
undetectable		 3pgyA-3ge4A:
17.51
3pgyB-3ge4A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ge4 DNA PROTECTION
DURING STARVATION
PROTEIN
(Brucella
melitensis) 		5 / 12 VAL A 125
SER A 150
PHE A  62
LEU A  66
VAL A 121
 None
 1.40A 4kyaB-3ge4A:
undetectable		 4kyaB-3ge4A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ge4 DNA PROTECTION
DURING STARVATION
PROTEIN
(Brucella
melitensis) 		5 / 12 VAL A 125
SER A 150
PHE A  62
LEU A  66
VAL A 121
 None
 1.40A 4kyaD-3ge4A:
undetectable		 4kyaD-3ge4A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ge4 DNA PROTECTION
DURING STARVATION
PROTEIN
(Brucella
melitensis) 		5 / 12 VAL A 125
SER A 150
PHE A  62
LEU A  66
VAL A 121
 None
 1.39A 4kyaF-3ge4A:
undetectable		 4kyaF-3ge4A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ge4 DNA PROTECTION
DURING STARVATION
PROTEIN
(Brucella
melitensis) 		5 / 12 VAL A 125
SER A 150
PHE A  62
LEU A  66
VAL A 121
 None
 1.39A 4kyaH-3ge4A:
undetectable		 4kyaH-3ge4A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3ge4 DNA PROTECTION
DURING STARVATION
PROTEIN
(Brucella
melitensis) 		4 / 4 ASN A 123
GLY A 119
ASP A  68
ASP A 152
 None
 1.37A 4n49A-3ge4A:
undetectable		 4n49A-3ge4A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 3ge4 DNA PROTECTION
DURING STARVATION
PROTEIN
(Brucella
melitensis) 		5 / 10 ASN A 123
ALA A 113
ILE A  39
LEU A  36
TYR A 100
 None
 1.20A 4xj7A-3ge4A:
undetectable
4xj7B-3ge4A:
undetectable		 4xj7A-3ge4A:
24.18
4xj7B-3ge4A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 3ge4 DNA PROTECTION
DURING STARVATION
PROTEIN
(Brucella
melitensis) 		4 / 4 LEU A 151
ILE A  73
HIS A  69
VAL A 125
 None
 1.07A 4xyzA-3ge4A:
undetectable		 4xyzA-3ge4A:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_DIFA601_1
(SERUM ALBUMIN)		 3ge4 DNA PROTECTION
DURING STARVATION
PROTEIN
(Brucella
melitensis) 		5 / 9 LEU A 155
ALA A 122
VAL A 125
ARG A 126
GLU A  65
 None
 1.48A 5dbyA-3ge4A:
1.2		 5dbyA-3ge4A:
15.33