SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3geh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWI_A_CAMA418_0
(CYTOCHROME P450-CAM)		 3geh TRNA MODIFICATION
GTPASE MNME
(Nostoc
sp.
PCC
7120) 		4 / 8 LEU A 237
VAL A 266
ASP A 245
VAL A 271
 None
 0.97A 1iwiA-3gehA:
undetectable		 1iwiA-3gehA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)		 3geh TRNA MODIFICATION
GTPASE MNME
(Nostoc
sp.
PCC
7120) 		4 / 8 TYR A  80
THR A 118
LEU A 127
VAL A 139
 FON  A 461 (-4.1A)
None
None
None
 1.16A 1uyuA-3gehA:
undetectable		 1uyuA-3gehA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3geh TRNA MODIFICATION
GTPASE MNME
(Nostoc
sp.
PCC
7120) 		4 / 8 LEU A 371
LEU A 330
VAL A 227
GLY A 228
 None
 0.94A 2po5B-3gehA:
3.0		 2po5B-3gehA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 3geh TRNA MODIFICATION
GTPASE MNME
(Nostoc
sp.
PCC
7120) 		5 / 11 LEU A 165
LEU A 435
ILE A 205
ALA A 400
LEU A 209
 None
 1.21A 2q72A-3gehA:
undetectable		 2q72A-3gehA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 3geh TRNA MODIFICATION
GTPASE MNME
(Nostoc
sp.
PCC
7120) 		4 / 5 GLN A  30
ALA A  33
GLN A  36
ILE A  34
 None
 1.49A 2z0aA-3gehA:
2.7		 2z0aA-3gehA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 3geh TRNA MODIFICATION
GTPASE MNME
(Nostoc
sp.
PCC
7120) 		3 / 3 ARG A 246
ILE A 368
THR A 307
 None
 0.68A 3ia4D-3gehA:
undetectable		 3ia4D-3gehA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3geh TRNA MODIFICATION
GTPASE MNME
(Nostoc
sp.
PCC
7120) 		5 / 12 ASP A 171
ILE A 172
ASP A 427
LEU A 428
ARG A 429
 None
 1.23A 3iv6B-3gehA:
undetectable		 3iv6B-3gehA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3geh TRNA MODIFICATION
GTPASE MNME
(Nostoc
sp.
PCC
7120) 		5 / 12 ASP A 171
ILE A 172
ASP A 427
LEU A 428
ARG A 429
 None
 1.17A 3iv6D-3gehA:
undetectable		 3iv6D-3gehA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 3geh TRNA MODIFICATION
GTPASE MNME
(Nostoc
sp.
PCC
7120) 		5 / 12 VAL A 333
LEU A 332
LEU A 371
GLY A 228
LEU A 237
 None
 1.08A 3pghD-3gehA:
undetectable		 3pghD-3gehA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 3geh TRNA MODIFICATION
GTPASE MNME
(Nostoc
sp.
PCC
7120) 		4 / 7 LEU A 237
VAL A 266
ASP A 245
VAL A 271
 None
 1.01A 4cp4A-3gehA:
undetectable		 4cp4A-3gehA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3geh TRNA MODIFICATION
GTPASE MNME
(Nostoc
sp.
PCC
7120) 		4 / 8 ALA A 413
GLN A 412
ASP A 197
ILE A 198
 None
 0.88A 4kttB-3gehA:
undetectable		 4kttB-3gehA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3geh TRNA MODIFICATION
GTPASE MNME
(Nostoc
sp.
PCC
7120) 		5 / 9 VAL A 333
LEU A 332
LEU A 371
GLY A 228
LEU A 237
 None
 0.96A 4rs0A-3gehA:
undetectable		 4rs0A-3gehA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 3geh TRNA MODIFICATION
GTPASE MNME
(Nostoc
sp.
PCC
7120) 		5 / 11 LEU A 237
LEU A 376
LEU A 303
LEU A 305
ILE A 331
 None
 1.04A 4zowA-3gehA:
3.3		 4zowA-3gehA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 3geh TRNA MODIFICATION
GTPASE MNME
(Nostoc
sp.
PCC
7120) 		4 / 4 VAL A 443
GLU A 437
GLY A 440
LEU A 129
 None
 1.18A 5g5gC-3gehA:
undetectable		 5g5gC-3gehA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 3geh TRNA MODIFICATION
GTPASE MNME
(Nostoc
sp.
PCC
7120) 		5 / 12 GLY A 153
LEU A 127
ALA A 136
LEU A 138
ALA A 141
 None
 0.96A 5kpcA-3gehA:
undetectable		 5kpcA-3gehA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 3geh TRNA MODIFICATION
GTPASE MNME
(Nostoc
sp.
PCC
7120) 		5 / 10 LEU A  38
ILE A  34
PHE A  88
ALA A 109
VAL A  24
 None
 1.36A 5m0oA-3gehA:
undetectable		 5m0oA-3gehA:
22.65