SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gei'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 3gei TRNA MODIFICATION
GTPASE MNME
(Chlorobaculum
tepidum) 		6 / 12 ALA A  28
GLY A 106
PRO A 102
GLY A 101
GLY A 100
LEU A 113
 None
 1.27A 1eizA-3geiA:
undetectable		 1eizA-3geiA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 3gei TRNA MODIFICATION
GTPASE MNME
(Chlorobaculum
tepidum) 		5 / 12 ALA A  28
GLY A 106
GLY A 101
GLY A 100
LEU A 113
 None
 0.94A 1ej0A-3geiA:
undetectable		 1ej0A-3geiA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3gei TRNA MODIFICATION
GTPASE MNME
(Chlorobaculum
tepidum) 		4 / 8 SER A 403
VAL A 404
LEU A 217
VAL A 449
 None
 0.85A 1fduB-3geiA:
3.6		 1fduB-3geiA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3gei TRNA MODIFICATION
GTPASE MNME
(Chlorobaculum
tepidum) 		4 / 6 VAL A  30
VAL A  22
ILE A 471
ARG A 107
 None
 1.04A 1iepA-3geiA:
2.6		 1iepA-3geiA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 3gei TRNA MODIFICATION
GTPASE MNME
(Chlorobaculum
tepidum) 		5 / 12 THR A  89
ILE A  29
GLY A 472
THR A  20
ALA A  16
 None
 1.12A 1nv8A-3geiA:
undetectable		 1nv8A-3geiA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 3gei TRNA MODIFICATION
GTPASE MNME
(Chlorobaculum
tepidum) 		5 / 12 GLU A  95
ALA A  79
VAL A  77
LEU A  67
VAL A  37
 None
 1.08A 1sn5B-3geiA:
undetectable
1sn5D-3geiA:
undetectable		 1sn5B-3geiA:
14.35
1sn5D-3geiA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 3gei TRNA MODIFICATION
GTPASE MNME
(Chlorobaculum
tepidum) 		5 / 12 LEU A  67
VAL A  37
GLU A  95
ALA A  79
VAL A  77
 None
 1.08A 1sn5B-3geiA:
undetectable
1sn5D-3geiA:
undetectable		 1sn5B-3geiA:
14.35
1sn5D-3geiA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 3gei TRNA MODIFICATION
GTPASE MNME
(Chlorobaculum
tepidum) 		5 / 12 THR A  89
ILE A  29
GLY A 472
THR A  20
ALA A  16
 None
 1.04A 1vq1A-3geiA:
undetectable		 1vq1A-3geiA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 3gei TRNA MODIFICATION
GTPASE MNME
(Chlorobaculum
tepidum) 		5 / 10 ILE A 363
ILE A 331
LEU A 317
ASN A 348
ILE A 374
 None
None
None
GCP  A 474 (-3.5A)
None
 1.24A 2nnhB-3geiA:
undetectable		 2nnhB-3geiA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 3gei TRNA MODIFICATION
GTPASE MNME
(Chlorobaculum
tepidum) 		3 / 3 ARG A 211
GLU A 208
GLN A 423
 None
 0.55A 2p16A-3geiA:
undetectable		 2p16A-3geiA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 3gei TRNA MODIFICATION
GTPASE MNME
(Chlorobaculum
tepidum) 		5 / 11 LEU A 137
LEU A 138
LEU A 166
ILE A 465
THR A 157
 None
 1.32A 2qd3A-3geiA:
3.6		 2qd3A-3geiA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3gei TRNA MODIFICATION
GTPASE MNME
(Chlorobaculum
tepidum) 		4 / 6 VAL A  30
VAL A  22
ILE A 471
ARG A 107
 None
 1.09A 3ms9A-3geiA:
3.3		 3ms9A-3geiA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3gei TRNA MODIFICATION
GTPASE MNME
(Chlorobaculum
tepidum) 		4 / 6 VAL A  30
VAL A  22
ILE A 471
ARG A 107
 None
 1.07A 3mssA-3geiA:
2.7		 3mssA-3geiA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3gei TRNA MODIFICATION
GTPASE MNME
(Chlorobaculum
tepidum) 		4 / 7 VAL A  30
VAL A  22
ILE A 471
ARG A 107
 None
 1.01A 3mssB-3geiA:
undetectable		 3mssB-3geiA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3gei TRNA MODIFICATION
GTPASE MNME
(Chlorobaculum
tepidum) 		4 / 6 VAL A  30
VAL A  22
ILE A 471
ARG A 107
 None
 1.10A 3mssC-3geiA:
undetectable		 3mssC-3geiA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 3gei TRNA MODIFICATION
GTPASE MNME
(Chlorobaculum
tepidum) 		4 / 5 PHE A 466
ILE A  15
ASN A 458
PHE A 125
 None
 1.27A 3octA-3geiA:
undetectable		 3octA-3geiA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 3gei TRNA MODIFICATION
GTPASE MNME
(Chlorobaculum
tepidum) 		5 / 12 ILE A  32
SER A  33
GLY A  34
GLU A  91
THR A  89
 None
 1.16A 3r75A-3geiA:
undetectable		 3r75A-3geiA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 3gei TRNA MODIFICATION
GTPASE MNME
(Chlorobaculum
tepidum) 		5 / 12 ILE A  32
SER A  33
GLY A  34
GLU A  91
THR A  89
 None
 1.16A 3r75B-3geiA:
undetectable		 3r75B-3geiA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 3gei TRNA MODIFICATION
GTPASE MNME
(Chlorobaculum
tepidum) 		5 / 11 ILE A  32
SER A  33
GLY A  34
GLU A  91
THR A  89
 None
 1.13A 3r76A-3geiA:
5.9		 3r76A-3geiA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 3gei TRNA MODIFICATION
GTPASE MNME
(Chlorobaculum
tepidum) 		5 / 11 ILE A  32
SER A  33
GLY A  34
GLU A  91
THR A  89
 None
 1.16A 3r76B-3geiA:
undetectable		 3r76B-3geiA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3gei TRNA MODIFICATION
GTPASE MNME
(Chlorobaculum
tepidum) 		4 / 6 GLY A 454
ILE A 452
GLN A 451
VAL A 461
 None
 1.03A 4d39B-3geiA:
undetectable		 4d39B-3geiA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3gei TRNA MODIFICATION
GTPASE MNME
(Chlorobaculum
tepidum) 		4 / 6 GLY A 454
ILE A 452
GLN A 451
VAL A 461
 None
 1.11A 4kcnA-3geiA:
undetectable		 4kcnA-3geiA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3gei TRNA MODIFICATION
GTPASE MNME
(Chlorobaculum
tepidum) 		5 / 11 LEU A 113
LEU A 109
GLU A 121
LEU A 119
GLU A 124
 None
 1.15A 4wg0H-3geiA:
undetectable
4wg0I-3geiA:
undetectable
4wg0J-3geiA:
undetectable		 4wg0H-3geiA:
2.34
4wg0I-3geiA:
2.34
4wg0J-3geiA:
2.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3gei TRNA MODIFICATION
GTPASE MNME
(Chlorobaculum
tepidum) 		5 / 12 THR A 345
ILE A 374
GLY A 373
LEU A 314
LEU A 312
 None
 1.00A 5nfjA-3geiA:
undetectable		 5nfjA-3geiA:
16.84