SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gem'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 3gem SHORT CHAIN
DEHYDROGENASE
(Pseudomonas
savastanoi) 		5 / 11 ILE A  64
ALA A  66
PHE A  58
LEU A   9
ILE A 114
 None
 1.14A 1dg5A-3gemA:
2.4		 1dg5A-3gemA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3gem SHORT CHAIN
DEHYDROGENASE
(Pseudomonas
savastanoi) 		3 / 3 LEU A  78
HIS A  83
ILE A 130
 None
 0.68A 1s9pB-3gemA:
undetectable		 1s9pB-3gemA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 3gem SHORT CHAIN
DEHYDROGENASE
(Pseudomonas
savastanoi) 		4 / 5 PRO A 177
VAL A 229
VAL A 208
ILE A 175
 None
 1.07A 1z2bC-3gemA:
6.8		 1z2bC-3gemA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 3gem SHORT CHAIN
DEHYDROGENASE
(Pseudomonas
savastanoi) 		4 / 6 LEU A 217
LEU A 216
ASP A 129
ILE A   8
 None
 1.13A 2rlfB-3gemA:
undetectable
2rlfC-3gemA:
undetectable		 2rlfB-3gemA:
11.02
2rlfC-3gemA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 3gem SHORT CHAIN
DEHYDROGENASE
(Pseudomonas
savastanoi) 		6 / 9 ALA A  51
VAL A  32
GLY A  29
LEU A  46
LEU A  23
ALA A  22
 None
 1.17A 2z0yA-3gemA:
2.1		 2z0yA-3gemA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 3gem SHORT CHAIN
DEHYDROGENASE
(Pseudomonas
savastanoi) 		6 / 9 ALA A  51
VAL A  32
GLY A  29
LEU A  46
LEU A  23
ALA A  22
 None
 1.31A 2z0yB-3gemA:
undetectable		 2z0yB-3gemA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3gem SHORT CHAIN
DEHYDROGENASE
(Pseudomonas
savastanoi) 		4 / 5 LEU A  78
THR A  75
THR A  11
HIS A  83
 None
 1.31A 2zj0B-3gemA:
7.6		 2zj0B-3gemA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3gem SHORT CHAIN
DEHYDROGENASE
(Pseudomonas
savastanoi) 		4 / 5 LEU A  78
GLN A  74
THR A  75
HIS A  83
 None
 1.32A 2zj0C-3gemA:
7.2		 2zj0C-3gemA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3gem SHORT CHAIN
DEHYDROGENASE
(Pseudomonas
savastanoi) 		4 / 5 LEU A  78
GLN A  74
THR A  75
HIS A  83
 None
 1.35A 3ce6B-3gemA:
8.2		 3ce6B-3gemA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3gem SHORT CHAIN
DEHYDROGENASE
(Pseudomonas
savastanoi) 		4 / 5 LEU A  78
GLN A  74
THR A  75
HIS A  83
 None
 1.30A 3n58C-3gemA:
7.9		 3n58C-3gemA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 3gem SHORT CHAIN
DEHYDROGENASE
(Pseudomonas
savastanoi) 		4 / 7 GLY A  18
TYR A 210
ALA A 206
GLU A 207
 None
 0.83A 4hyfA-3gemA:
undetectable		 4hyfA-3gemA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 3gem SHORT CHAIN
DEHYDROGENASE
(Pseudomonas
savastanoi) 		4 / 8 GLY A  18
TYR A 210
ALA A 206
GLU A 207
 None
 0.85A 4hyfB-3gemA:
undetectable		 4hyfB-3gemA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 3gem SHORT CHAIN
DEHYDROGENASE
(Pseudomonas
savastanoi) 		4 / 8 GLY A  18
TYR A 210
ALA A 206
GLU A 207
 None
 0.90A 4hyfC-3gemA:
undetectable		 4hyfC-3gemA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)		 3gem SHORT CHAIN
DEHYDROGENASE
(Pseudomonas
savastanoi) 		4 / 8 SER A  59
LEU A 109
SER A 105
THR A 101
 None
 0.98A 4iklA-3gemA:
undetectable
4iklB-3gemA:
undetectable		 4iklA-3gemA:
19.31
4iklB-3gemA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3gem SHORT CHAIN
DEHYDROGENASE
(Pseudomonas
savastanoi) 		4 / 8 ILE A  33
LEU A   9
ILE A  34
PHE A  67
 None
 0.88A 4v04A-3gemA:
undetectable		 4v04A-3gemA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_1
(PAVINE
N-METHYLTRANSFERASE)		 3gem SHORT CHAIN
DEHYDROGENASE
(Pseudomonas
savastanoi) 		4 / 5 PHE A  58
SER A  59
GLN A  15
ASP A 135
 None
 1.44A 5kpcA-3gemA:
3.9		 5kpcA-3gemA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3gem SHORT CHAIN
DEHYDROGENASE
(Pseudomonas
savastanoi) 		5 / 12 ILE A  10
HIS A  30
ALA A  22
ALA A  13
VAL A  17
 None
 1.08A 5n0oB-3gemA:
2.1		 5n0oB-3gemA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 3gem SHORT CHAIN
DEHYDROGENASE
(Pseudomonas
savastanoi) 		4 / 6 ALA A   6
SER A   5
ALA A 124
SER A  77
 None
 1.00A 6bocA-3gemA:
undetectable
6bocB-3gemA:
undetectable
6bocC-3gemA:
undetectable
6bocD-3gemA:
undetectable		 6bocA-3gemA:
7.60
6bocB-3gemA:
7.60
6bocC-3gemA:
7.60
6bocD-3gemA:
7.60