SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gfa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_2
(HIV-II PROTEASE)		 3gfa PUTATIVE
NITROREDUCTASE
(Clostridioides
difficile) 		5 / 9 ILE A 173
GLY A  32
ILE A  33
ILE A  25
ILE A  99
 None
 0.87A 1hshB-3gfaA:
undetectable		 1hshB-3gfaA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3gfa PUTATIVE
NITROREDUCTASE
(Clostridioides
difficile) 		4 / 7 LEU A  75
TYR A 153
TYR A 156
GLY A  64
 None
 1.02A 1lweA-3gfaA:
undetectable		 1lweA-3gfaA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3gfa PUTATIVE
NITROREDUCTASE
(Clostridioides
difficile) 		5 / 10 GLU A  90
GLY A  84
LEU A  75
ILE A  65
MET A  61
 GOL  A 201 (-4.9A)
None
None
None
None
 1.38A 3adsA-3gfaA:
undetectable		 3adsA-3gfaA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 3gfa PUTATIVE
NITROREDUCTASE
(Clostridioides
difficile) 		4 / 5 SER A  78
GLY A  77
GLU A  68
PHE A 154
 None
 1.34A 4r82A-3gfaA:
undetectable
4r82B-3gfaA:
undetectable		 4r82A-3gfaA:
20.83
4r82B-3gfaA:
20.83