SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gfb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		4 / 4 LEU A 182
PRO A 153
LEU A 179
ARG A 204
 None
None
NAD  A 500 (-4.1A)
NAD  A 500 (-2.6A)
 1.38A 1hrkB-3gfbA:
3.2		 1hrkB-3gfbA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC2_0
(ACTINOMYCIN D)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		3 / 3 THR A  11
PRO A  13
PRO A  62
 None
 0.84A 2d55C-3gfbA:
undetectable		 2d55C-3gfbA:
4.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		4 / 4 LEU A 182
PRO A 153
LEU A 179
ARG A 204
 None
None
NAD  A 500 (-4.1A)
NAD  A 500 (-2.6A)
 1.32A 2hrcB-3gfbA:
3.0		 2hrcB-3gfbA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		4 / 4 LEU A 182
PRO A 153
LEU A 179
ARG A 204
 None
None
NAD  A 500 (-4.1A)
NAD  A 500 (-2.6A)
 1.41A 2pnjB-3gfbA:
3.1		 2pnjB-3gfbA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		3 / 3 LEU A 179
PRO A 178
LEU A 182
 NAD  A 500 (-4.1A)
NAD  A 500 (-3.4A)
None
 0.59A 2po5B-3gfbA:
3.3		 2po5B-3gfbA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		3 / 3 ASP A 230
THR A 258
PRO A 259
 None
 0.72A 2pynB-3gfbA:
undetectable		 2pynB-3gfbA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		4 / 4 LEU A 182
PRO A 153
LEU A 179
ARG A 204
 None
None
NAD  A 500 (-4.1A)
NAD  A 500 (-2.6A)
 1.44A 2qd2A-3gfbA:
3.5		 2qd2A-3gfbA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		5 / 12 GLY A 175
ALA A 176
GLU A 199
SER A 201
ALA A 246
 NAD  A 500 (-3.2A)
None
NAD  A 500 (-2.8A)
None
NAD  A 500 (-3.3A)
 1.17A 3id6C-3gfbA:
6.8		 3id6C-3gfbA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		4 / 5 SER A 201
ARG A 204
ARG A 336
GLU A 333
 None
NAD  A 500 (-2.6A)
None
None
 1.12A 3k9fA-3gfbA:
undetectable
3k9fB-3gfbA:
undetectable
3k9fC-3gfbA:
undetectable		 3k9fA-3gfbA:
22.31
3k9fB-3gfbA:
22.31
3k9fC-3gfbA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		4 / 6 ARG A 204
SER A 201
ARG A 336
GLU A 333
 NAD  A 500 (-2.6A)
None
None
None
 1.12A 3k9fA-3gfbA:
undetectable
3k9fB-3gfbA:
undetectable
3k9fD-3gfbA:
undetectable		 3k9fA-3gfbA:
22.31
3k9fB-3gfbA:
22.31
3k9fD-3gfbA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		5 / 12 GLY A 212
GLY A 180
GLY A 183
LEU A 241
SER A 244
 None
NAD  A 500 ( 4.9A)
None
None
NAD  A 500 (-4.0A)
 1.08A 3kkzB-3gfbA:
5.9		 3kkzB-3gfbA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		3 / 3 ILE A 166
VAL A 239
ARG A 262
 None
 0.75A 3p73A-3gfbA:
undetectable		 3p73A-3gfbA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		4 / 7 ILE A 318
LEU A 150
ALA A  38
ALA A  70
 None
 0.87A 3r9tB-3gfbA:
undetectable		 3r9tB-3gfbA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		3 / 3 LEU A 266
GLU A 242
SER A 264
 NAD  A 500 (-4.2A)
None
None
 0.66A 4ccqA-3gfbA:
3.5		 4ccqA-3gfbA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		5 / 12 GLY A  66
ILE A  48
PHE A 325
ILE A   8
PHE A 345
 None
 1.25A 4fglA-3gfbA:
4.2
4fglB-3gfbA:
4.1		 4fglA-3gfbA:
22.19
4fglB-3gfbA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 275
GLN A 252
LEU A 250
ALA A 249
ILE A 282
 None
None
None
NAD  A 500 (-3.5A)
None
 0.99A 4nqaH-3gfbA:
undetectable		 4nqaH-3gfbA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_B_Z80B401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		5 / 9 ILE A 231
PHE A 227
VAL A 237
THR A 171
ASP A 214
 None
 1.40A 5lg3B-3gfbA:
undetectable		 5lg3B-3gfbA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_C_Z80C401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		5 / 9 ILE A 231
PHE A 227
VAL A 237
THR A 171
ASP A 214
 None
 1.42A 5lg3C-3gfbA:
undetectable		 5lg3C-3gfbA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_D_Z80D401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		5 / 9 ILE A 231
PHE A 227
VAL A 237
THR A 171
ASP A 214
 None
 1.42A 5lg3D-3gfbA:
undetectable		 5lg3D-3gfbA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGJ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		3 / 3 VAL A  32
VAL A  76
GLN A  84
 None
 0.57A 5qgjA-3gfbA:
undetectable		 5qgjA-3gfbA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGL_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		3 / 3 VAL A  32
VAL A  76
GLN A  84
 None
 0.69A 5qglA-3gfbA:
undetectable		 5qglA-3gfbA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGM_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		3 / 3 VAL A  32
VAL A  76
GLN A  84
 None
 0.49A 5qgmA-3gfbA:
undetectable		 5qgmA-3gfbA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGN_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		3 / 3 VAL A  32
VAL A  76
GLN A  84
 None
 0.59A 5qgnA-3gfbA:
undetectable		 5qgnA-3gfbA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGU_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		3 / 3 VAL A  32
VAL A  76
GLN A  84
 None
 0.62A 5qguA-3gfbA:
undetectable		 5qguA-3gfbA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGV_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		3 / 3 VAL A  32
VAL A  76
GLN A  84
 None
 0.61A 5qgvA-3gfbA:
undetectable		 5qgvA-3gfbA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGW_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		3 / 3 VAL A  32
VAL A  76
GLN A  84
 None
 0.61A 5qgwA-3gfbA:
undetectable		 5qgwA-3gfbA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGX_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		3 / 3 VAL A  32
VAL A  76
GLN A  84
 None
 0.62A 5qgxA-3gfbA:
undetectable		 5qgxA-3gfbA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGY_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		3 / 3 VAL A  32
VAL A  76
GLN A  84
 None
 0.61A 5qgyA-3gfbA:
undetectable		 5qgyA-3gfbA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGZ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		3 / 3 VAL A  32
VAL A  76
GLN A  84
 None
 0.60A 5qgzA-3gfbA:
undetectable		 5qgzA-3gfbA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH0_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		3 / 3 VAL A  32
VAL A  76
GLN A  84
 None
 0.62A 5qh0A-3gfbA:
undetectable		 5qh0A-3gfbA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH1_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		3 / 3 VAL A  32
VAL A  76
GLN A  84
 None
 0.61A 5qh1A-3gfbA:
undetectable		 5qh1A-3gfbA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH2_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		3 / 3 VAL A  32
VAL A  76
GLN A  84
 None
 0.62A 5qh2A-3gfbA:
undetectable		 5qh2A-3gfbA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH3_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		3 / 3 VAL A  32
VAL A  76
GLN A  84
 None
 0.60A 5qh3A-3gfbA:
undetectable		 5qh3A-3gfbA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH4_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		3 / 3 VAL A  32
VAL A  76
GLN A  84
 None
 0.60A 5qh4A-3gfbA:
undetectable		 5qh4A-3gfbA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH5_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		3 / 3 VAL A  32
VAL A  76
GLN A  84
 None
 0.56A 5qh5A-3gfbA:
undetectable		 5qh5A-3gfbA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH6_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		3 / 3 VAL A  32
VAL A  76
GLN A  84
 None
 0.56A 5qh6A-3gfbA:
undetectable		 5qh6A-3gfbA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH7_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		3 / 3 VAL A  32
VAL A  76
GLN A  84
 None
 0.59A 5qh7A-3gfbA:
undetectable		 5qh7A-3gfbA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH9_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		3 / 3 VAL A  32
VAL A  76
GLN A  84
 None
 0.56A 5qh9A-3gfbA:
undetectable		 5qh9A-3gfbA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHA_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		3 / 3 VAL A  32
VAL A  76
GLN A  84
 None
 0.62A 5qhaA-3gfbA:
undetectable		 5qhaA-3gfbA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHC_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		3 / 3 VAL A  32
VAL A  76
GLN A  84
 None
 0.61A 5qhcA-3gfbA:
undetectable		 5qhcA-3gfbA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHE_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		3 / 3 VAL A  32
VAL A  76
GLN A  84
 None
 0.60A 5qheA-3gfbA:
undetectable		 5qheA-3gfbA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHF_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		3 / 3 VAL A  32
VAL A  76
GLN A  84
 None
 0.58A 5qhfA-3gfbA:
undetectable		 5qhfA-3gfbA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		3 / 3 VAL A  32
VAL A  76
GLN A  84
 None
 0.58A 5qhgA-3gfbA:
undetectable		 5qhgA-3gfbA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHH_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		3 / 3 VAL A  32
VAL A  76
GLN A  84
 None
 0.61A 5qhhA-3gfbA:
undetectable		 5qhhA-3gfbA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		5 / 12 GLN A 151
ALA A 149
GLU A  92
VAL A 124
PHE A 117
 None
 1.29A 5vlmG-3gfbA:
undetectable		 5vlmG-3gfbA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		5 / 12 GLN A 151
GLU A  92
ILE A  89
VAL A 124
PHE A 117
 None
 1.22A 5vlmG-3gfbA:
undetectable		 5vlmG-3gfbA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		5 / 12 GLY A 164
ASP A 159
VAL A 110
GLY A 290
ILE A 291
 None
 1.19A 5vooE-3gfbA:
undetectable		 5vooE-3gfbA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		5 / 12 GLY A 164
ASP A 159
VAL A 110
GLY A 290
ILE A 291
 None
 1.20A 5vooF-3gfbA:
2.4		 5vooF-3gfbA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		5 / 12 GLY A 164
ASP A 159
VAL A 110
GLY A 290
ILE A 291
 None
 1.14A 5vopB-3gfbA:
2.1		 5vopB-3gfbA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 3gfb L-THREONINE
3-DEHYDROGENASE
(Thermococcus
kodakarensis) 		4 / 5 THR A 292
THR A  93
HIS A  67
GLY A 155
 NAD  A 500 (-3.6A)
None
None
None
 1.13A 6gbnC-3gfbA:
2.9		 6gbnC-3gfbA:
22.67