SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gff'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 3gff IROE-LIKE SERINE
HYDROLASE
(Shewanella
oneidensis) 		5 / 12 MET A 198
LEU A 196
TYR A 164
VAL A 186
PHE A 222
 None
 1.27A 1a27A-3gffA:
4.4		 1a27A-3gffA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_D_PAUD6004_0
(PANTOTHENATE KINASE)		 3gff IROE-LIKE SERINE
HYDROLASE
(Shewanella
oneidensis) 		5 / 10 VAL A 141
GLY A 253
HIS A  56
LEU A 167
ILE A 258
 None
 1.45A 1sq5D-3gffA:
undetectable		 1sq5D-3gffA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 3gff IROE-LIKE SERINE
HYDROLASE
(Shewanella
oneidensis) 		5 / 11 ASN A 202
TYR A 241
LEU A 220
ILE A 200
ASP A 168
 None
 1.15A 1t6zB-3gffA:
undetectable		 1t6zB-3gffA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 3gff IROE-LIKE SERINE
HYDROLASE
(Shewanella
oneidensis) 		5 / 11 VAL A 249
TYR A 241
LEU A 220
ILE A 200
ASP A 168
 None
 1.23A 1t6zB-3gffA:
undetectable		 1t6zB-3gffA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 3gff IROE-LIKE SERINE
HYDROLASE
(Shewanella
oneidensis) 		5 / 10 GLY A 147
GLY A 146
TYR A  89
SER A 170
HIS A 246
 None
None
None
IMD  A 332 (-3.2A)
IMD  A 332 (-3.5A)
 1.30A 1w76B-3gffA:
11.9		 1w76B-3gffA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)		 3gff IROE-LIKE SERINE
HYDROLASE
(Shewanella
oneidensis) 		4 / 7 THR A  90
PRO A  91
GLY A 111
THR A  94
 None
 0.98A 2vl2B-3gffA:
undetectable		 2vl2B-3gffA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 3gff IROE-LIKE SERINE
HYDROLASE
(Shewanella
oneidensis) 		5 / 12 ILE A  80
ASN A 135
LEU A 124
VAL A 149
LEU A 140
 None
 1.17A 3a51D-3gffA:
undetectable		 3a51D-3gffA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3gff IROE-LIKE SERINE
HYDROLASE
(Shewanella
oneidensis) 		4 / 6 GLN A 299
TYR A  42
ILE A  76
SER A  38
 None
 1.22A 3peoG-3gffA:
undetectable		 3peoG-3gffA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 3gff IROE-LIKE SERINE
HYDROLASE
(Shewanella
oneidensis) 		4 / 8 ASN A 219
PHE A 222
ALA A 223
THR A 227
 None
 0.94A 3t3sF-3gffA:
undetectable		 3t3sF-3gffA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3gff IROE-LIKE SERINE
HYDROLASE
(Shewanella
oneidensis) 		5 / 12 ILE A  76
VAL A  78
ILE A 120
ALA A 125
LEU A 132
 None
 0.79A 4o1zA-3gffA:
undetectable		 4o1zA-3gffA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3gff IROE-LIKE SERINE
HYDROLASE
(Shewanella
oneidensis) 		5 / 12 GLY A 257
LEU A 154
PHE A 191
GLY A 189
LEU A 226
 None
 1.31A 4ze1A-3gffA:
undetectable		 4ze1A-3gffA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 3gff IROE-LIKE SERINE
HYDROLASE
(Shewanella
oneidensis) 		4 / 5 VAL A 149
ASN A  82
ASP A  49
LEU A  48
 None
 1.32A 5m0iB-3gffA:
undetectable		 5m0iB-3gffA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_0
(REGULATORY PROTEIN
TETR)		 3gff IROE-LIKE SERINE
HYDROLASE
(Shewanella
oneidensis) 		5 / 12 ALA A 125
SER A 127
LEU A  16
TYR A  89
VAL A  78
 None
 1.37A 5vlmH-3gffA:
undetectable		 5vlmH-3gffA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3gff IROE-LIKE SERINE
HYDROLASE
(Shewanella
oneidensis) 		5 / 12 LEU A 167
GLN A 247
GLY A 147
SER A 250
GLY A 142
 None
 0.97A 5wyqB-3gffA:
2.1		 5wyqB-3gffA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 3gff IROE-LIKE SERINE
HYDROLASE
(Shewanella
oneidensis) 		5 / 12 PHE A 116
GLY A  79
GLY A  50
TYR A  11
ILE A  29
 None
 1.00A 6b3aA-3gffA:
undetectable		 6b3aA-3gffA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 3gff IROE-LIKE SERINE
HYDROLASE
(Shewanella
oneidensis) 		5 / 12 PHE A 116
GLY A  79
GLY A  50
TYR A  11
ILE A  29
 None
 0.99A 6b3bA-3gffA:
undetectable		 6b3bA-3gffA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 3gff IROE-LIKE SERINE
HYDROLASE
(Shewanella
oneidensis) 		4 / 8 ASN A 135
PHE A 265
VAL A 139
SER A 162
 None
 1.13A 6huoC-3gffA:
undetectable
6huoD-3gffA:
undetectable		 6huoC-3gffA:
12.77
6huoD-3gffA:
13.75