SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gfm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 3gfm 146AA LONG
HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR
(Sulfurisphaera
tokodaii) 		4 / 8 GLU A  25
ARG A  28
LEU A 114
GLU A 117
 None
 1.01A 1cmaA-3gfmA:
undetectable
1cmaB-3gfmA:
undetectable		 1cmaA-3gfmA:
20.27
1cmaB-3gfmA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 3gfm 146AA LONG
HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR
(Sulfurisphaera
tokodaii) 		5 / 11 GLU A  25
ARG A  28
ARG A  29
LEU A 114
GLU A 117
 None
 1.08A 1cmaA-3gfmA:
undetectable
1cmaB-3gfmA:
undetectable		 1cmaA-3gfmA:
20.27
1cmaB-3gfmA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 3gfm 146AA LONG
HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR
(Sulfurisphaera
tokodaii) 		5 / 10 GLU A  25
ARG A  28
ARG A  29
LEU A 114
GLU A 117
 None
 0.99A 1cmcA-3gfmA:
undetectable
1cmcB-3gfmA:
undetectable		 1cmcA-3gfmA:
20.27
1cmcB-3gfmA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 3gfm 146AA LONG
HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR
(Sulfurisphaera
tokodaii) 		5 / 12 GLU A  25
ARG A  28
ARG A  29
LEU A 114
GLU A 117
 None
 1.02A 1mj2A-3gfmA:
undetectable
1mj2B-3gfmA:
undetectable		 1mj2A-3gfmA:
20.27
1mj2B-3gfmA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_0
(PROTEIN (METHIONINE
REPRESSOR))		 3gfm 146AA LONG
HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR
(Sulfurisphaera
tokodaii) 		5 / 9 GLU A  25
ARG A  28
ARG A  29
LEU A 114
GLU A 117
 None
 1.00A 1mj2A-3gfmA:
undetectable		 1mj2A-3gfmA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_0
(PROTEIN (METHIONINE
REPRESSOR))		 3gfm 146AA LONG
HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR
(Sulfurisphaera
tokodaii) 		5 / 9 GLU A  25
ARG A  28
ARG A  29
LEU A 114
GLU A 117
 None
 1.01A 1mj2C-3gfmA:
undetectable		 1mj2C-3gfmA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 3gfm 146AA LONG
HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR
(Sulfurisphaera
tokodaii) 		5 / 12 GLU A  25
ARG A  28
ARG A  29
LEU A 114
GLU A 117
 None
 1.00A 1mj2C-3gfmA:
undetectable
1mj2D-3gfmA:
undetectable		 1mj2C-3gfmA:
20.27
1mj2D-3gfmA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 3gfm 146AA LONG
HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR
(Sulfurisphaera
tokodaii) 		5 / 11 GLU A  25
ARG A  28
ARG A  29
LEU A 114
GLU A 117
 None
 0.83A 1mjlA-3gfmA:
undetectable
1mjlB-3gfmA:
undetectable		 1mjlA-3gfmA:
20.27
1mjlB-3gfmA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_0
(METHIONINE REPRESSOR)		 3gfm 146AA LONG
HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR
(Sulfurisphaera
tokodaii) 		5 / 9 GLU A  25
ARG A  28
ARG A  29
LEU A 114
GLU A 117
 None
 1.04A 1mjoA-3gfmA:
undetectable		 1mjoA-3gfmA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_1
(METHIONINE REPRESSOR)		 3gfm 146AA LONG
HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR
(Sulfurisphaera
tokodaii) 		5 / 9 GLU A  25
ARG A  28
ARG A  29
LEU A 114
GLU A 117
 None
 1.02A 1mjoB-3gfmA:
undetectable		 1mjoB-3gfmA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 3gfm 146AA LONG
HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR
(Sulfurisphaera
tokodaii) 		5 / 12 GLU A  25
ARG A  28
ARG A  29
LEU A 114
GLU A 117
 None
 1.00A 1mjoC-3gfmA:
undetectable
1mjoD-3gfmA:
undetectable		 1mjoC-3gfmA:
20.27
1mjoD-3gfmA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_0
(METHIONINE REPRESSOR)		 3gfm 146AA LONG
HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR
(Sulfurisphaera
tokodaii) 		5 / 9 GLU A  25
ARG A  28
ARG A  29
LEU A 114
GLU A 117
 None
 1.02A 1mjoC-3gfmA:
undetectable		 1mjoC-3gfmA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 3gfm 146AA LONG
HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR
(Sulfurisphaera
tokodaii) 		4 / 4 LEU A  93
ASP A  72
VAL A  80
THR A  46
 None
 1.26A 3cyxB-3gfmA:
undetectable		 3cyxB-3gfmA:
21.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GF2_A_SALA147_1
(146AA LONG
HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR)		 3gfm 146AA LONG
HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR
(Sulfurisphaera
tokodaii) 		4 / 4 TYR A  37
LEU A  41
ARG A  44
TYR A 111
 None
 0.14A 3gf2A-3gfmA:
24.2		 3gf2A-3gfmA:
99.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 3gfm 146AA LONG
HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR
(Sulfurisphaera
tokodaii) 		5 / 12 LEU A  56
GLN A  64
ALA A  69
ASP A  72
VAL A  42
 None
 0.93A 4wnwB-3gfmA:
undetectable		 4wnwB-3gfmA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3gfm 146AA LONG
HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR
(Sulfurisphaera
tokodaii) 		5 / 11 SER A  70
ILE A  67
MET A  53
LEU A  56
ILE A  96
 None
 1.12A 4xumB-3gfmA:
undetectable		 4xumB-3gfmA:
21.30