SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gfq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 3gfq FMN-DEPENDENT
NADPH-AZOREDUCTASE
(Bacillus
subtilis) 		4 / 8 LEU A 134
ALA A 100
LEU A 102
THR A   9
 None
None
None
FMN  A 200 (-2.9A)
 0.79A 1dvtA-3gfqA:
undetectable
1dvtB-3gfqA:
undetectable		 1dvtA-3gfqA:
21.05
1dvtB-3gfqA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3gfq FMN-DEPENDENT
NADPH-AZOREDUCTASE
(Bacillus
subtilis) 		4 / 8 SER A  21
ALA A  20
ALA A  19
ILE A 141
 None
 0.64A 1gtnI-3gfqA:
undetectable
1gtnJ-3gfqA:
undetectable		 1gtnI-3gfqA:
17.16
1gtnJ-3gfqA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 3gfq FMN-DEPENDENT
NADPH-AZOREDUCTASE
(Bacillus
subtilis) 		5 / 12 GLY A  77
SER A  76
LEU A 115
ASP A  87
LEU A  86
 None
FMN  A 200 (-4.2A)
None
None
None
 1.09A 1i9gA-3gfqA:
undetectable		 1i9gA-3gfqA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3gfq FMN-DEPENDENT
NADPH-AZOREDUCTASE
(Bacillus
subtilis) 		4 / 4 PHE A  88
VAL A  54
ALA A  85
PHE A  37
 None
 1.19A 4f3tA-3gfqA:
2.2		 4f3tA-3gfqA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 3gfq FMN-DEPENDENT
NADPH-AZOREDUCTASE
(Bacillus
subtilis) 		4 / 5 PHE A  88
VAL A  54
ALA A  85
PHE A  37
 None
 1.20A 4w5oA-3gfqA:
3.2		 4w5oA-3gfqA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3gfq FMN-DEPENDENT
NADPH-AZOREDUCTASE
(Bacillus
subtilis) 		4 / 4 PHE A  88
VAL A  54
ALA A  85
PHE A  37
 None
 1.23A 4w5qA-3gfqA:
2.1		 4w5qA-3gfqA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3gfq FMN-DEPENDENT
NADPH-AZOREDUCTASE
(Bacillus
subtilis) 		4 / 4 PHE A  88
VAL A  54
ALA A  85
PHE A  37
 None
 1.19A 4w5rA-3gfqA:
3.4		 4w5rA-3gfqA:
12.22