SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ggd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3ggd SAM-DEPENDENT
METHYLTRANSFERASE
(Trichormus
variabilis) 		5 / 12 LEU A 160
LEU A 152
LEU A 148
GLY A 145
PHE A 198
 None
 1.32A 1d4fA-3ggdA:
2.1		 1d4fA-3ggdA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3ggd SAM-DEPENDENT
METHYLTRANSFERASE
(Trichormus
variabilis) 		4 / 6 ILE A 102
VAL A  80
VAL A 240
ILE A 161
 None
None
None
EDO  A 255 (-4.5A)
 0.71A 1uwhA-3ggdA:
undetectable		 1uwhA-3ggdA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3ggd SAM-DEPENDENT
METHYLTRANSFERASE
(Trichormus
variabilis) 		4 / 6 ILE A 102
VAL A  80
VAL A 240
ILE A 161
 None
None
None
EDO  A 255 (-4.5A)
 0.71A 1uwhB-3ggdA:
undetectable		 1uwhB-3ggdA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 3ggd SAM-DEPENDENT
METHYLTRANSFERASE
(Trichormus
variabilis) 		3 / 3 TRP A  18
LEU A 110
LYS A 140
 SAH  A 248 (-3.7A)
SAH  A 248 ( 4.2A)
CL  A 247 (-3.2A)
 1.36A 1yajK-3ggdA:
undetectable		 1yajK-3ggdA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 3ggd SAM-DEPENDENT
METHYLTRANSFERASE
(Trichormus
variabilis) 		3 / 3 ARG A 130
ASP A  84
ASP A 108
 SAH  A 248 ( 3.9A)
SAH  A 248 (-2.9A)
SAH  A 248 (-3.7A)
 0.52A 2ejtA-3ggdA:
9.6		 2ejtA-3ggdA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 3ggd SAM-DEPENDENT
METHYLTRANSFERASE
(Trichormus
variabilis) 		4 / 7 ALA A  63
GLY A  65
ASP A  84
ASP A 108
 SAH  A 248 (-3.2A)
SAH  A 248 (-3.2A)
SAH  A 248 (-2.9A)
SAH  A 248 (-3.7A)
 0.30A 2uyqA-3ggdA:
11.7		 2uyqA-3ggdA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 3ggd SAM-DEPENDENT
METHYLTRANSFERASE
(Trichormus
variabilis) 		3 / 3 GLY A  65
ASP A  84
SER A  86
 SAH  A 248 (-3.2A)
SAH  A 248 (-2.9A)
None
 0.70A 3brfA-3ggdA:
undetectable		 3brfA-3ggdA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 3ggd SAM-DEPENDENT
METHYLTRANSFERASE
(Trichormus
variabilis) 		3 / 3 CYH A 167
PHE A 170
PHE A 171
 None
 0.97A 3cr5X-3ggdA:
undetectable		 3cr5X-3ggdA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3ggd SAM-DEPENDENT
METHYLTRANSFERASE
(Trichormus
variabilis) 		3 / 3 GLY A  65
ASP A  84
ASP A 108
 SAH  A 248 (-3.2A)
SAH  A 248 (-2.9A)
SAH  A 248 (-3.7A)
 0.36A 3ou7C-3ggdA:
16.7		 3ou7C-3ggdA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_C_ACTC506_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3ggd SAM-DEPENDENT
METHYLTRANSFERASE
(Trichormus
variabilis) 		4 / 5 ARG A 141
ILE A 136
HIS A 135
GLY A 132
 None
None
SAH  A 248 ( 4.5A)
SAH  A 248 ( 4.8A)
 1.41A 4e7cC-3ggdA:
undetectable		 4e7cC-3ggdA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRQ_C_AVLC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3ggd SAM-DEPENDENT
METHYLTRANSFERASE
(Trichormus
variabilis) 		4 / 7 PHE A  72
GLN A  69
TYR A 128
PHE A  49
 None
 1.36A 4grqA-3ggdA:
undetectable
4grqC-3ggdA:
undetectable		 4grqA-3ggdA:
21.28
4grqC-3ggdA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 3ggd SAM-DEPENDENT
METHYLTRANSFERASE
(Trichormus
variabilis) 		3 / 3 LYS A 242
LEU A 213
ALA A 157
 SO4  A 252 (-3.0A)
None
None
 0.79A 4iizA-3ggdA:
undetectable		 4iizA-3ggdA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 3ggd SAM-DEPENDENT
METHYLTRANSFERASE
(Trichormus
variabilis) 		4 / 7 ILE A  81
LEU A 107
LEU A 151
ILE A 127
 SO4  A 251 ( 4.4A)
EDO  A 262 (-4.7A)
None
None
 0.80A 4rmjA-3ggdA:
4.4		 4rmjA-3ggdA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 3ggd SAM-DEPENDENT
METHYLTRANSFERASE
(Trichormus
variabilis) 		4 / 7 GLY A 218
ARG A  48
ALA A 236
ILE A 161
 EDO  A 261 (-3.9A)
EDO  A 261 ( 3.8A)
None
EDO  A 255 (-4.5A)
 0.93A 4txnA-3ggdA:
undetectable		 4txnA-3ggdA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 3ggd SAM-DEPENDENT
METHYLTRANSFERASE
(Trichormus
variabilis) 		4 / 7 GLY A 218
ARG A  48
ALA A 236
ILE A 161
 EDO  A 261 (-3.9A)
EDO  A 261 ( 3.8A)
None
EDO  A 255 (-4.5A)
 0.97A 4txnB-3ggdA:
undetectable		 4txnB-3ggdA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 3ggd SAM-DEPENDENT
METHYLTRANSFERASE
(Trichormus
variabilis) 		4 / 7 GLY A 218
ARG A  48
ALA A 236
ILE A 161
 EDO  A 261 (-3.9A)
EDO  A 261 ( 3.8A)
None
EDO  A 255 (-4.5A)
 0.93A 4txnD-3ggdA:
undetectable		 4txnD-3ggdA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3ggd SAM-DEPENDENT
METHYLTRANSFERASE
(Trichormus
variabilis) 		4 / 8 PHE A 171
PRO A 182
LEU A 175
LEU A 174
 None
EDO  A 259 (-3.5A)
None
EDO  A 259 ( 4.1A)
 0.91A 5dzkd-3ggdA:
undetectable
5dzkr-3ggdA:
undetectable		 5dzkd-3ggdA:
20.91
5dzkr-3ggdA:
1.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3ggd SAM-DEPENDENT
METHYLTRANSFERASE
(Trichormus
variabilis) 		5 / 12 ILE A 193
GLY A 192
HIS A 135
ILE A 168
PHE A 171
 None
None
SAH  A 248 ( 4.5A)
SO4  A 250 (-3.6A)
None
 1.27A 5igwA-3ggdA:
undetectable		 5igwA-3ggdA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3ggd SAM-DEPENDENT
METHYLTRANSFERASE
(Trichormus
variabilis) 		3 / 3 ASP A  61
ASN A  66
PHE A 133
 SAH  A 248 ( 4.8A)
None
None
 0.90A 5jglB-3ggdA:
13.5		 5jglB-3ggdA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3ggd SAM-DEPENDENT
METHYLTRANSFERASE
(Trichormus
variabilis) 		5 / 12 ILE A  60
PHE A 133
ILE A 212
ALA A 239
LEU A 160
 None
None
EDO  A 258 (-3.8A)
None
None
 1.26A 5oy02-3ggdA:
undetectable		 5oy02-3ggdA:
16.46