SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ggg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 3ggg PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 12 VAL D  36
SER D  98
GLY D  60
GLY D  75
ALA D  46
 None
 1.08A 1jg4A-3gggD:
3.1		 1jg4A-3gggD:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3ggg PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 7 THR D 120
PHE D  94
PHE D 143
LEU D 172
 None
 0.98A 1qcaA-3gggD:
undetectable		 1qcaA-3gggD:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3ggg PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 6 VAL D 186
LEU D 185
PHE D  45
SER D  52
 None
 1.08A 1wrlB-3gggD:
undetectable		 1wrlB-3gggD:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3ggg PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 6 LEU D 139
LYS D 110
VAL D  36
ILE D  84
 None
 1.09A 2hyyB-3gggD:
undetectable		 2hyyB-3gggD:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 3ggg PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 5 ASP D  62
ILE D  58
ILE D  68
GLY D  37
 NAD  D6686 (-2.9A)
None
None
NAD  D6686 (-3.4A)
 0.88A 3bufA-3gggD:
undetectable		 3bufA-3gggD:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_A_ADNA439_1
(ADENOSYLHOMOCYSTEINA
SE)		 3ggg PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 10 THR D 120
LEU D 172
GLY D 145
MET D  96
PHE D  94
 None
 1.39A 3h9uA-3gggD:
8.8		 3h9uA-3gggD:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_A_ADNA439_1
(ADENOSYLHOMOCYSTEINA
SE)		 3ggg PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 10 THR D 120
LEU D 172
GLY D 146
MET D  96
PHE D  94
 None
 1.04A 3h9uA-3gggD:
8.8		 3h9uA-3gggD:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3ggg PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 10 THR D 120
LEU D 172
GLY D 145
MET D  96
PHE D  94
 None
 1.40A 3h9uB-3gggD:
3.5		 3h9uB-3gggD:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3ggg PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 10 THR D 120
LEU D 172
GLY D 146
MET D  96
PHE D  94
 None
 1.07A 3h9uB-3gggD:
3.5		 3h9uB-3gggD:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3ggg PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 10 THR D 120
LEU D 172
GLY D 145
MET D  96
PHE D  94
 None
 1.42A 3h9uC-3gggD:
8.4		 3h9uC-3gggD:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3ggg PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 10 THR D 120
LEU D 172
GLY D 146
MET D  96
PHE D  94
 None
 1.09A 3h9uC-3gggD:
8.4		 3h9uC-3gggD:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3ggg PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 10 THR D 120
LEU D 172
GLY D 145
MET D  96
PHE D  94
 None
 1.41A 3h9uD-3gggD:
3.3		 3h9uD-3gggD:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3ggg PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 10 THR D 120
LEU D 172
GLY D 146
MET D  96
PHE D  94
 None
 1.08A 3h9uD-3gggD:
3.3		 3h9uD-3gggD:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 3ggg PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 6 SER D  98
ILE D  35
ASP D 162
THR D 152
 None
 1.06A 3q70A-3gggD:
undetectable		 3q70A-3gggD:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 3ggg PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		3 / 3 HIS D 147
HIS D 205
ILE D 171
 NAD  D6686 ( 4.9A)
None
None
 0.83A 3u52A-3gggD:
undetectable
3u52C-3gggD:
undetectable		 3u52A-3gggD:
20.58
3u52C-3gggD:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3ggg PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 12 GLY D  42
GLY D  43
ALA D  71
ILE D  63
ASN D  64
 None
None
None
NAD  D6686 (-4.0A)
None
 1.04A 4rtmA-3gggD:
4.1		 4rtmA-3gggD:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3ggg PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 12 GLY D  39
SER D  44
ILE D  63
ASN D  64
PRO D 100
 NAD  D6686 (-3.3A)
None
NAD  D6686 (-4.0A)
None
NAD  D6686 (-4.6A)
 1.14A 4rtpA-3gggD:
4.9		 4rtpA-3gggD:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3ggg PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 12 GLY D  39
ASP D  62
ILE D  63
ASN D  64
PRO D 100
 NAD  D6686 (-3.3A)
NAD  D6686 (-2.9A)
NAD  D6686 (-4.0A)
None
NAD  D6686 (-4.6A)
 0.95A 4rtsA-3gggD:
undetectable		 4rtsA-3gggD:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 3ggg PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 7 ARG D 142
VAL D 121
LEU D 111
SER D 112
 None
 0.85A 4zphA-3gggD:
undetectable
4zphB-3gggD:
undetectable		 4zphA-3gggD:
22.89
4zphB-3gggD:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3ggg PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 10 PHE D 248
ALA D 222
LEU D 223
ILE D 288
LEU D 296
 None
 1.09A 5oy01-3gggD:
undetectable
5oy07-3gggD:
undetectable		 5oy01-3gggD:
15.04
5oy07-3gggD:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 3ggg PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 7 SER D  99
LEU D  97
ILE D 138
LEU D 139
 NAD  D6686 (-4.7A)
None
None
None
 0.93A 5te8C-3gggD:
undetectable		 5te8C-3gggD:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_0
(ADENOSYLHOMOCYSTEINA
SE)		 3ggg PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 12 THR D 120
LEU D 172
GLY D 145
MET D  96
PHE D  94
 None
 1.37A 6exiA-3gggD:
3.6		 6exiA-3gggD:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_0
(ADENOSYLHOMOCYSTEINA
SE)		 3ggg PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 12 THR D 120
LEU D 172
GLY D 146
MET D  96
PHE D  94
 None
 1.04A 6exiA-3gggD:
3.6		 6exiA-3gggD:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_0
(ADENOSYLHOMOCYSTEINA
SE)		 3ggg PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 12 THR D 120
LEU D 172
GLY D 145
MET D  96
PHE D  94
 None
 1.44A 6exiD-3gggD:
2.8		 6exiD-3gggD:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_0
(ADENOSYLHOMOCYSTEINA
SE)		 3ggg PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 12 THR D 120
LEU D 172
GLY D 146
MET D  96
PHE D  94
 None
 1.05A 6exiD-3gggD:
2.8		 6exiD-3gggD:
12.88