SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ggr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 3ggr CELL CYCLE
CHECKPOINT CONTROL
PROTEIN RAD9A
(Homo
sapiens) 		5 / 12 LEU A 256
PHE A  84
ALA A  16
PHE A  80
LEU A 225
 None
 1.39A 1brpA-3ggrA:
undetectable		 1brpA-3ggrA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3ggr CELL CYCLE
CHECKPOINT CONTROL
PROTEIN RAD9A
(Homo
sapiens) 		5 / 12 LEU A  36
LEU A  13
VAL A  17
ILE A  99
PHE A  80
 None
 1.05A 3fl9B-3ggrA:
undetectable		 3fl9B-3ggrA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3ggr CELL CYCLE
CHECKPOINT CONTROL
PROTEIN RAD9A
(Homo
sapiens) 		5 / 12 LEU A  36
LEU A  13
VAL A  17
ILE A  99
PHE A  80
 None
 1.09A 3fl9G-3ggrA:
undetectable		 3fl9G-3ggrA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 3ggr CELL CYCLE
CHECKPOINT CONTROL
PROTEIN RAD9A
(Homo
sapiens) 		5 / 11 MET A  77
VAL A  17
ILE A  99
PHE A  80
THR A  40
 None
 1.09A 3jw5A-3ggrA:
undetectable		 3jw5A-3ggrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 3ggr CELL CYCLE
CHECKPOINT CONTROL
PROTEIN RAD9A
(Homo
sapiens) 		5 / 10 MET A  77
VAL A  17
ILE A  99
PHE A  80
THR A  40
 None
 1.11A 3jw5B-3ggrA:
undetectable		 3jw5B-3ggrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 3ggr CELL CYCLE
CHECKPOINT CONTROL
PROTEIN RAD9A
(Homo
sapiens) 		4 / 5 VAL A  17
LEU A  38
LEU A  27
ILE A  99
 None
 0.95A 4a9jB-3ggrA:
undetectable		 4a9jB-3ggrA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 3ggr CELL CYCLE
CHECKPOINT CONTROL
PROTEIN RAD9A
(Homo
sapiens) 		4 / 5 VAL A  17
LEU A  38
LEU A  27
ILE A  99
 None
 0.92A 4a9jC-3ggrA:
undetectable		 4a9jC-3ggrA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 3ggr CELL CYCLE
CHECKPOINT CONTROL
PROTEIN RAD9A
(Homo
sapiens) 		5 / 7 PHE A 249
PHE A 217
GLY A 169
THR A 167
PHE A 222
 None
 1.50A 4ejjA-3ggrA:
undetectable		 4ejjA-3ggrA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 3ggr CELL CYCLE
CHECKPOINT CONTROL
PROTEIN RAD9A
(Homo
sapiens) 		3 / 3 PHE A  84
VAL A  10
GLU A  95
 None
 0.82A 4fvqA-3ggrA:
undetectable		 4fvqA-3ggrA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 3ggr CELL CYCLE
CHECKPOINT CONTROL
PROTEIN RAD9A
(Homo
sapiens) 		3 / 3 CYH A  97
LYS A  96
HIS A 113
 None
 1.00A 5js5A-3ggrA:
undetectable		 5js5A-3ggrA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3ggr CELL CYCLE
CHECKPOINT CONTROL
PROTEIN RAD9A
(Homo
sapiens) 		5 / 12 SER A 237
VAL A 176
GLY A 171
PHE A 222
VAL A 151
 None
 1.26A 6a94A-3ggrA:
undetectable		 6a94A-3ggrA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 3ggr CELL CYCLE
CHECKPOINT CONTROL
PROTEIN RAD9A
(Homo
sapiens) 		4 / 7 VAL A 261
LEU A 255
PHE A  53
PHE A 136
 None
 1.15A 6aycA-3ggrA:
undetectable		 6aycA-3ggrA:
16.54