SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gha'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 3gha DISULFIDE BOND
FORMATION PROTEIN D
(Bacillus
subtilis) 		3 / 3 TRP A 118
PHE A 125
TRP A 126
 None
 1.16A 1r15C-3ghaA:
undetectable		 1r15C-3ghaA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 3gha DISULFIDE BOND
FORMATION PROTEIN D
(Bacillus
subtilis) 		3 / 3 TRP A 118
PHE A 125
TRP A 126
 None
 1.15A 1r15F-3ghaA:
undetectable		 1r15F-3ghaA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 3gha DISULFIDE BOND
FORMATION PROTEIN D
(Bacillus
subtilis) 		3 / 3 TRP A 118
PHE A 125
TRP A 126
 None
 1.17A 1r15G-3ghaA:
undetectable		 1r15G-3ghaA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 3gha DISULFIDE BOND
FORMATION PROTEIN D
(Bacillus
subtilis) 		3 / 3 TRP A 118
PHE A 125
TRP A 126
 None
 1.17A 1r15H-3ghaA:
undetectable		 1r15H-3ghaA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3gha DISULFIDE BOND
FORMATION PROTEIN D
(Bacillus
subtilis) 		5 / 12 GLU A  63
PHE A  97
HIS A 129
ALA A 153
LEU A 148
 EDO  A 301 (-3.6A)
EDO  A 301 (-4.6A)
EDO  A 301 (-3.8A)
None
None
 1.18A 2xkwB-3ghaA:
undetectable		 2xkwB-3ghaA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 3gha DISULFIDE BOND
FORMATION PROTEIN D
(Bacillus
subtilis) 		3 / 3 GLU A 216
ASP A  86
ASP A 209
 None
 0.69A 3jb2A-3ghaA:
undetectable		 3jb2A-3ghaA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_B_KKKB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3gha DISULFIDE BOND
FORMATION PROTEIN D
(Bacillus
subtilis) 		5 / 12 PHE A  75
TYR A  67
GLY A 150
ALA A 153
THR A 157
 None
 1.47A 3ld6B-3ghaA:
undetectable		 3ld6B-3ghaA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 3gha DISULFIDE BOND
FORMATION PROTEIN D
(Bacillus
subtilis) 		3 / 3 TYR A 208
ASP A  92
ASP A  86
 None
 0.68A 3r24A-3ghaA:
undetectable		 3r24A-3ghaA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 3gha DISULFIDE BOND
FORMATION PROTEIN D
(Bacillus
subtilis) 		4 / 7 ALA A 113
PHE A 128
PRO A 146
LEU A 164
 None
 0.79A 4du2A-3ghaA:
undetectable		 4du2A-3ghaA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 3gha DISULFIDE BOND
FORMATION PROTEIN D
(Bacillus
subtilis) 		4 / 7 PHE A 128
PHE A 125
ALA A 111
LEU A 168
 None
 0.88A 4ejgC-3ghaA:
undetectable		 4ejgC-3ghaA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 3gha DISULFIDE BOND
FORMATION PROTEIN D
(Bacillus
subtilis) 		3 / 3 LYS A 212
ASN A 198
ASP A  86
 None
 0.79A 4o1eA-3ghaA:
undetectable		 4o1eA-3ghaA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 3gha DISULFIDE BOND
FORMATION PROTEIN D
(Bacillus
subtilis) 		5 / 12 ASP A  66
GLY A  65
HIS A 103
ALA A 111
HIS A 129
 None
None
None
None
EDO  A 301 (-3.8A)
 1.33A 4wh5A-3ghaA:
undetectable		 4wh5A-3ghaA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 3gha DISULFIDE BOND
FORMATION PROTEIN D
(Bacillus
subtilis) 		4 / 6 ILE A  83
PHE A  95
ILE A 195
GLU A  63
 None
EDO  A 301 (-4.1A)
None
EDO  A 301 (-3.6A)
 1.11A 4zzcA-3ghaA:
undetectable
4zzcB-3ghaA:
undetectable		 4zzcA-3ghaA:
19.69
4zzcB-3ghaA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 3gha DISULFIDE BOND
FORMATION PROTEIN D
(Bacillus
subtilis) 		4 / 6 ILE A  83
PHE A  95
ILE A 195
GLU A  63
 None
EDO  A 301 (-4.1A)
None
EDO  A 301 (-3.6A)
 1.12A 4zzcB-3ghaA:
undetectable
4zzcC-3ghaA:
undetectable		 4zzcB-3ghaA:
19.69
4zzcC-3ghaA:
19.69