SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ghg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 3ghg FIBRINOGEN GAMMA
CHAIN
(Homo
sapiens) 		3 / 3 ASP C 294
ASP C 298
ASP C 291
 ASP  C 294 ( 0.5A)
ASP  C 298 ( 0.6A)
ASP  C 291 ( 0.6A)
 0.79A 1eizA-3ghgC:
undetectable		 1eizA-3ghgC:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 3ghg FIBRINOGEN GAMMA
CHAIN
(Homo
sapiens) 		3 / 3 ASP C 294
ASP C 298
ASP C 291
 ASP  C 294 ( 0.5A)
ASP  C 298 ( 0.6A)
ASP  C 291 ( 0.6A)
 0.74A 1ej0A-3ghgC:
undetectable		 1ej0A-3ghgC:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 3ghg FIBRINOGEN GAMMA
CHAIN
(Homo
sapiens) 		3 / 3 PHE C 290
VAL C 248
TRP C 369
 PHE  C 290 ( 1.3A)
VAL  C 248 ( 0.6A)
TRP  C 369 ( 0.5A)
 0.89A 2cc8A-3ghgC:
undetectable		 2cc8A-3ghgC:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 3ghg FIBRINOGEN GAMMA
CHAIN
(Homo
sapiens) 		3 / 3 PHE C 290
VAL C 248
TRP C 369
 PHE  C 290 ( 1.3A)
VAL  C 248 ( 0.6A)
TRP  C 369 ( 0.5A)
 0.87A 2ccbA-3ghgC:
undetectable		 2ccbA-3ghgC:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 3ghg FIBRINOGEN GAMMA
CHAIN
(Homo
sapiens) 		3 / 3 PHE C 290
VAL C 248
TRP C 369
 PHE  C 290 ( 1.3A)
VAL  C 248 ( 0.6A)
TRP  C 369 ( 0.5A)
 0.87A 2vx9A-3ghgC:
undetectable		 2vx9A-3ghgC:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 3ghg FIBRINOGEN GAMMA
CHAIN
(Homo
sapiens) 		5 / 10 ALA C 341
ALA C 289
LEU C 250
MET C 384
VAL C 248
 ALA  C 341 ( 0.0A)
ALA  C 289 ( 0.0A)
LEU  C 250 ( 0.6A)
MET  C 384 ( 0.0A)
VAL  C 248 ( 0.6A)
 1.09A 2wuzA-3ghgC:
undetectable		 2wuzA-3ghgC:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 3ghg FIBRINOGEN GAMMA
CHAIN
(Homo
sapiens) 		5 / 10 ALA C 341
ALA C 289
LEU C 250
MET C 384
VAL C 248
 ALA  C 341 ( 0.0A)
ALA  C 289 ( 0.0A)
LEU  C 250 ( 0.6A)
MET  C 384 ( 0.0A)
VAL  C 248 ( 0.6A)
 1.07A 2wuzB-3ghgC:
undetectable		 2wuzB-3ghgC:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 3ghg FIBRINOGEN GAMMA
CHAIN
(Homo
sapiens) 		3 / 3 LEU C 276
TRP C 334
GLY C 342
 LEU  C 276 ( 0.6A)
TRP  C 334 ( 0.5A)
GLY  C 342 ( 0.0A)
 0.78A 3l35B-3ghgC:
4.1
3l35K-3ghgC:
undetectable		 3l35B-3ghgC:
7.20
3l35K-3ghgC:
5.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 3ghg FIBRINOGEN GAMMA
CHAIN
(Homo
sapiens) 		5 / 12 GLY C 284
ALA C 263
ALA C 245
THR C 393
LEU C 392
 GLY  C 284 ( 0.0A)
ALA  C 263 ( 0.0A)
ALA  C 245 ( 0.0A)
THR  C 393 ( 0.8A)
LEU  C 392 ( 0.5A)
 1.02A 3mteB-3ghgC:
undetectable		 3mteB-3ghgC:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_B_017B202_1
(PROTEASE)		 3ghg FIBRINOGEN GAMMA
CHAIN
(Homo
sapiens) 		4 / 7 LYS C 273
ARG C 275
GLY C 268
PRO C 269
 LYS  C 273 ( 0.0A)
ARG  C 275 ( 0.6A)
GLY  C 268 ( 0.0A)
PRO  C 269 ( 1.1A)
 1.32A 3ucbB-3ghgC:
undetectable		 3ucbB-3ghgC:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRQ_C_AVLC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3ghg FIBRINOGEN GAMMA
CHAIN
(Homo
sapiens) 		4 / 7 PHE C 215
TYR C 211
GLN C 195
PHE C 312
 PHE  C 215 ( 1.3A)
TYR  C 211 ( 1.3A)
GLN  C 195 ( 0.6A)
PHE  C 312 ( 1.3A)
 1.39A 4grqA-3ghgC:
undetectable
4grqC-3ghgC:
undetectable		 4grqA-3ghgC:
13.33
4grqC-3ghgC:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRQ_C_AVLC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3ghg FIBRINOGEN GAMMA
CHAIN
(Homo
sapiens) 		4 / 7 PHE C 215
TYR C 211
TRP C 227
PHE C 312
 PHE  C 215 ( 1.3A)
TYR  C 211 ( 1.3A)
TRP  C 227 ( 0.5A)
PHE  C 312 ( 1.3A)
 1.29A 4grqA-3ghgC:
undetectable
4grqC-3ghgC:
undetectable		 4grqA-3ghgC:
13.33
4grqC-3ghgC:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3ghg FIBRINOGEN GAMMA
CHAIN
(Homo
sapiens) 		6 / 12 MET C 384
VAL C 248
LEU C 246
LEU C 344
PHE C 295
ALA C 289
 MET  C 384 ( 0.0A)
VAL  C 248 ( 0.6A)
LEU  C 246 ( 0.6A)
LEU  C 344 ( 0.6A)
PHE  C 295 ( 1.3A)
ALA  C 289 ( 0.0A)
 1.50A 4o1zB-3ghgC:
undetectable		 4o1zB-3ghgC:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 3ghg FIBRINOGEN GAMMA
CHAIN
(Homo
sapiens) 		5 / 12 GLY C 200
GLU C 225
ASN C 365
SER C 378
ILE C 367
 GLY  C 200 ( 0.0A)
GLU  C 225 ( 0.5A)
ASN  C 365 ( 0.6A)
SER  C 378 ( 0.0A)
ILE  C 367 ( 0.5A)
 1.26A 4pb1A-3ghgC:
undetectable		 4pb1A-3ghgC:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3ghg FIBRINOGEN GAMMA
CHAIN
(Homo
sapiens) 		4 / 6 ARG C 247
ASP C 285
GLY C 284
ASP C 261
 ARG  C 247 ( 0.6A)
ASP  C 285 ( 0.6A)
GLY  C 284 ( 0.0A)
ASP  C 261 ( 0.6A)
 1.34A 5hp1A-3ghgC:
undetectable		 5hp1A-3ghgC:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 3ghg FIBRINOGEN ALPHA
CHAIN
(Homo
sapiens) 		3 / 3 ARG A 162
ARG A 167
ARG A 171
 ARG  A 162 ( 0.6A)
ARG  A 167 ( 0.6A)
ARG  A 171 ( 0.6A)
 0.93A 5vcgA-3ghgA:
undetectable		 5vcgA-3ghgA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_H_BEZH201_0
(NS3 PROTEASE)		 3ghg FIBRINOGEN GAMMA
CHAIN
(Homo
sapiens) 		4 / 5 HIS C 343
SER C 332
TYR C 211
GLY C 333
 HIS  C 343 ( 1.0A)
SER  C 332 ( 0.0A)
TYR  C 211 ( 1.3A)
GLY  C 333 ( 0.0A)
 1.37A 5yodH-3ghgC:
undetectable		 5yodH-3ghgC:
19.16