SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ghy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 3ghy KETOPANTOATE
REDUCTASE PROTEIN
(Ralstonia
solanacearum) 		5 / 10 VAL A  72
VAL A  74
ALA A 133
ALA A  85
ILE A 130
 None
 1.09A 1likA-3ghyA:
5.2		 1likA-3ghyA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 3ghy KETOPANTOATE
REDUCTASE PROTEIN
(Ralstonia
solanacearum) 		5 / 12 ALA A 242
PHE A 203
GLY A 257
LEU A 236
LEU A 226
 None
 1.01A 1ya4A-3ghyA:
undetectable		 1ya4A-3ghyA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 3ghy KETOPANTOATE
REDUCTASE PROTEIN
(Ralstonia
solanacearum) 		5 / 12 PHE A 203
GLY A 257
LEU A 236
MET A 211
LEU A 226
 None
 0.83A 1ya4A-3ghyA:
undetectable		 1ya4A-3ghyA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 3ghy KETOPANTOATE
REDUCTASE PROTEIN
(Ralstonia
solanacearum) 		5 / 12 PHE A 203
GLY A 257
LEU A 236
MET A 211
LEU A 226
 None
 0.89A 1ya4C-3ghyA:
undetectable		 1ya4C-3ghyA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 3ghy KETOPANTOATE
REDUCTASE PROTEIN
(Ralstonia
solanacearum) 		5 / 10 PHE A 109
VAL A 294
ILE A 249
GLY A 246
LEU A 205
 None
 1.11A 1z11C-3ghyA:
undetectable		 1z11C-3ghyA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 3ghy KETOPANTOATE
REDUCTASE PROTEIN
(Ralstonia
solanacearum) 		5 / 10 PHE A 109
VAL A 294
ILE A 249
GLY A 246
LEU A 205
 None
 1.08A 1z11D-3ghyA:
undetectable		 1z11D-3ghyA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 3ghy KETOPANTOATE
REDUCTASE PROTEIN
(Ralstonia
solanacearum) 		3 / 3 ASP A  70
VAL A  98
PRO A 135
 None
 0.50A 2avvA-3ghyA:
undetectable		 2avvA-3ghyA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B2000_1
(P38A)		 3ghy KETOPANTOATE
REDUCTASE PROTEIN
(Ralstonia
solanacearum) 		5 / 10 ILE A 134
ILE A 197
ILE A 165
TRP A 108
VAL A  74
 None
 1.42A 3ohtA-3ghyA:
1.3
3ohtB-3ghyA:
undetectable		 3ohtA-3ghyA:
20.40
3ohtB-3ghyA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 3ghy KETOPANTOATE
REDUCTASE PROTEIN
(Ralstonia
solanacearum) 		5 / 11 PHE A 109
VAL A 294
ILE A 249
GLY A 246
LEU A 205
 None
 1.12A 3t3rA-3ghyA:
undetectable		 3t3rA-3ghyA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3ghy KETOPANTOATE
REDUCTASE PROTEIN
(Ralstonia
solanacearum) 		4 / 5 ARG A 224
VAL A 214
LEU A 217
SER A 215
 None
 1.17A 4e1gA-3ghyA:
undetectable		 4e1gA-3ghyA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3ghy KETOPANTOATE
REDUCTASE PROTEIN
(Ralstonia
solanacearum) 		5 / 10 SER A 174
ALA A 181
LEU A 166
GLY A 167
ALA A   9
 None
 0.98A 4fe1A-3ghyA:
undetectable
4fe1J-3ghyA:
undetectable		 4fe1A-3ghyA:
17.15
4fe1J-3ghyA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3ghy KETOPANTOATE
REDUCTASE PROTEIN
(Ralstonia
solanacearum) 		5 / 12 GLY A 141
GLY A 167
VAL A  72
PHE A 184
ILE A 180
 None
 1.07A 4fglA-3ghyA:
4.4
4fglB-3ghyA:
4.3		 4fglA-3ghyA:
21.65
4fglB-3ghyA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 3ghy KETOPANTOATE
REDUCTASE PROTEIN
(Ralstonia
solanacearum) 		5 / 9 SER A 174
ALA A 181
LEU A 166
GLY A 167
ALA A  11
 None
 1.47A 4l6va-3ghyA:
undetectable
4l6vf-3ghyA:
undetectable		 4l6va-3ghyA:
18.31
4l6vf-3ghyA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3ghy KETOPANTOATE
REDUCTASE PROTEIN
(Ralstonia
solanacearum) 		5 / 12 CYH A  97
GLY A  95
PRO A  94
GLY A  93
ILE A 180
 None
 0.94A 4n48A-3ghyA:
3.2		 4n48A-3ghyA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3ghy KETOPANTOATE
REDUCTASE PROTEIN
(Ralstonia
solanacearum) 		5 / 12 CYH A  97
GLY A  95
PRO A  94
GLY A  93
ILE A 180
 None
 0.98A 4n49A-3ghyA:
3.1		 4n49A-3ghyA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 3ghy KETOPANTOATE
REDUCTASE PROTEIN
(Ralstonia
solanacearum) 		4 / 8 ALA A 123
ILE A 249
GLU A 296
GLY A 298
 None
 0.82A 4r20A-3ghyA:
undetectable		 4r20A-3ghyA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 3ghy KETOPANTOATE
REDUCTASE PROTEIN
(Ralstonia
solanacearum) 		4 / 8 SER A 174
ALA A 181
LEU A 166
GLY A 167
 None
 0.81A 4xk8a-3ghyA:
undetectable		 4xk8a-3ghyA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_2
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 3ghy KETOPANTOATE
REDUCTASE PROTEIN
(Ralstonia
solanacearum) 		4 / 5 LEU A  36
CYH A   5
LEU A  91
ASP A  62
 None
 1.31A 5mafA-3ghyA:
undetectable		 5mafA-3ghyA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3ghy KETOPANTOATE
REDUCTASE PROTEIN
(Ralstonia
solanacearum) 		3 / 3 CYH A 222
MET A 211
ASN A 212
 None
 1.31A 5qh8A-3ghyA:
undetectable		 5qh8A-3ghyA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 3ghy KETOPANTOATE
REDUCTASE PROTEIN
(Ralstonia
solanacearum) 		4 / 6 PHE A 184
ARG A 162
LEU A 164
GLN A 190
 None
 1.07A 6b89B-3ghyA:
undetectable		 6b89B-3ghyA:
15.33