SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gir'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 3gir AMINOMETHYLTRANSFERA
SE
(Bartonella
henselae) 		5 / 11 LEU A  17
LEU A 170
LEU A  57
VAL A 152
ILE A 202
 None
 0.83A 1ee2A-3girA:
undetectable		 1ee2A-3girA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 3gir AMINOMETHYLTRANSFERA
SE
(Bartonella
henselae) 		5 / 11 LEU A  17
LEU A 170
LEU A  57
VAL A 152
ILE A 202
 None
 0.88A 1ee2B-3girA:
undetectable		 1ee2B-3girA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3gir AMINOMETHYLTRANSFERA
SE
(Bartonella
henselae) 		5 / 12 LEU A 149
LEU A  65
ALA A 123
LEU A 109
ILE A 147
 None
 0.98A 1s9pC-3girA:
undetectable		 1s9pC-3girA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3gir AMINOMETHYLTRANSFERA
SE
(Bartonella
henselae) 		5 / 12 LEU A 149
LEU A  65
ALA A 123
LEU A 109
ILE A 147
 None
 0.97A 1s9pD-3girA:
undetectable		 1s9pD-3girA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 3gir AMINOMETHYLTRANSFERA
SE
(Bartonella
henselae) 		5 / 11 GLY A  91
GLY A 180
SER A  93
PHE A 188
PHE A 119
 None
 1.36A 1w76A-3girA:
undetectable		 1w76A-3girA:
21.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WOP_A_FFOA2887_0
(AMINOMETHYLTRANSFERA
SE)		 3gir AMINOMETHYLTRANSFERA
SE
(Bartonella
henselae) 		8 / 12 MET A  63
TYR A  95
VAL A 122
ASN A 124
TYR A 369
TYR A 194
ARG A 230
TRP A 259
 None
 1.11A 1wopA-3girA:
48.1		 1wopA-3girA:
31.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 3gir AMINOMETHYLTRANSFERA
SE
(Bartonella
henselae) 		10 / 12 MET A  63
ILE A 110
VAL A 122
ASN A 124
PHE A 177
MET A 178
TYR A 194
ARG A 230
LEU A 239
TRP A 259
 None
 0.55A 1wsvA-3girA:
50.0		 1wsvA-3girA:
40.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 3gir AMINOMETHYLTRANSFERA
SE
(Bartonella
henselae) 		3 / 3 ASP A 108
GLU A 201
TYR A 369
 None
 0.27A 1wsvA-3girA:
50.0		 1wsvA-3girA:
40.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 3gir AMINOMETHYLTRANSFERA
SE
(Bartonella
henselae) 		9 / 12 MET A  63
ILE A 110
VAL A 122
ASN A 124
PHE A 177
MET A 178
TYR A 194
LEU A 239
TRP A 259
 None
 0.52A 1wsvB-3girA:
50.1		 1wsvB-3girA:
40.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WSV_B_THHB4001_1
(AMINOMETHYLTRANSFERA
SE)		 3gir AMINOMETHYLTRANSFERA
SE
(Bartonella
henselae) 		4 / 4 ASP A 108
GLU A 201
ARG A 230
TYR A 369
 None
 0.40A 1wsvB-3girA:
50.1		 1wsvB-3girA:
40.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3gir AMINOMETHYLTRANSFERA
SE
(Bartonella
henselae) 		4 / 8 GLY A  43
GLY A 226
ALA A 228
ALA A 229
 None
 0.55A 2ej3A-3girA:
undetectable		 2ej3A-3girA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3gir AMINOMETHYLTRANSFERA
SE
(Bartonella
henselae) 		3 / 3 LEU A  15
PRO A  16
LEU A  17
 None
 0.63A 2po5B-3girA:
undetectable		 2po5B-3girA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3gir AMINOMETHYLTRANSFERA
SE
(Bartonella
henselae) 		4 / 8 LEU A  57
LEU A 154
LEU A 165
ALA A 168
 None
 0.82A 2vcvP-3girA:
undetectable		 2vcvP-3girA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 3gir AMINOMETHYLTRANSFERA
SE
(Bartonella
henselae) 		4 / 7 ARG A 102
TYR A 272
ARG A 138
GLU A 134
 None
 1.20A 2zt7A-3girA:
undetectable		 2zt7A-3girA:
21.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A8I_A_C2FA401_0
(AMINOMETHYLTRANSFERA
SE)		 3gir AMINOMETHYLTRANSFERA
SE
(Bartonella
henselae) 		8 / 12 MET A  63
TYR A  95
ASP A 108
ILE A 110
VAL A 122
ASN A 124
TYR A 194
ARG A 230
 None
 0.48A 3a8iA-3girA:
45.7		 3a8iA-3girA:
34.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A8I_B_C2FB401_0
(AMINOMETHYLTRANSFERA
SE)		 3gir AMINOMETHYLTRANSFERA
SE
(Bartonella
henselae) 		9 / 12 MET A  63
TYR A  95
ASP A 108
ILE A 110
VAL A 122
ASN A 124
TYR A 194
ARG A 230
TRP A 259
 None
 0.47A 3a8iB-3girA:
45.3		 3a8iB-3girA:
34.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A8I_C_C2FC401_0
(AMINOMETHYLTRANSFERA
SE)		 3gir AMINOMETHYLTRANSFERA
SE
(Bartonella
henselae) 		8 / 12 MET A  63
TYR A  95
ILE A 110
VAL A 122
ASN A 124
TYR A 194
ARG A 230
TRP A 259
 None
 0.39A 3a8iC-3girA:
45.2		 3a8iC-3girA:
34.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A8I_D_C2FD401_0
(AMINOMETHYLTRANSFERA
SE)		 3gir AMINOMETHYLTRANSFERA
SE
(Bartonella
henselae) 		9 / 12 MET A  63
TYR A  95
ASP A 108
ILE A 110
VAL A 122
ASN A 124
TYR A 194
ARG A 230
TRP A 259
 None
 0.50A 3a8iD-3girA:
45.2		 3a8iD-3girA:
34.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 3gir AMINOMETHYLTRANSFERA
SE
(Bartonella
henselae) 		4 / 4 GLU A 342
GLY A 343
THR A 344
GLU A 345
 None
 1.02A 3e9xA-3girA:
undetectable		 3e9xA-3girA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3gir AMINOMETHYLTRANSFERA
SE
(Bartonella
henselae) 		3 / 3 LEU A 227
LEU A  38
ARG A  35
 None
 0.74A 3hcnB-3girA:
undetectable		 3hcnB-3girA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 3gir AMINOMETHYLTRANSFERA
SE
(Bartonella
henselae) 		3 / 3 SER A  93
GLY A 180
SER A 192
 None
 0.63A 3loqA-3girA:
undetectable		 3loqA-3girA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 3gir AMINOMETHYLTRANSFERA
SE
(Bartonella
henselae) 		4 / 7 TYR A 194
ASN A 244
LEU A 241
ASP A 231
 None
 1.36A 3lslA-3girA:
undetectable
3lslD-3girA:
undetectable		 3lslA-3girA:
20.71
3lslD-3girA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 3gir AMINOMETHYLTRANSFERA
SE
(Bartonella
henselae) 		4 / 7 TYR A 194
ASN A 244
LEU A 241
ASP A 231
 None
 1.37A 3lslA-3girA:
undetectable
3lslD-3girA:
undetectable		 3lslA-3girA:
20.71
3lslD-3girA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 3gir AMINOMETHYLTRANSFERA
SE
(Bartonella
henselae) 		4 / 6 TYR A 194
ASN A 244
LEU A 241
ASP A 231
 None
 1.36A 3lslG-3girA:
undetectable		 3lslG-3girA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 3gir AMINOMETHYLTRANSFERA
SE
(Bartonella
henselae) 		3 / 3 ARG A  94
THR A 258
TRP A 259
 None
 1.22A 4d7hA-3girA:
undetectable		 4d7hA-3girA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 3gir AMINOMETHYLTRANSFERA
SE
(Bartonella
henselae) 		4 / 8 ASN A 244
ALA A 302
SER A 319
ARG A 301
 None
 1.16A 4ijiF-3girA:
undetectable		 4ijiF-3girA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 3gir AMINOMETHYLTRANSFERA
SE
(Bartonella
henselae) 		4 / 7 ASN A 244
ALA A 302
SER A 319
ARG A 301
 None
 1.13A 4ijiH-3girA:
undetectable		 4ijiH-3girA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3gir AMINOMETHYLTRANSFERA
SE
(Bartonella
henselae) 		5 / 12 GLY A  91
THR A 190
ILE A 202
GLY A 172
LEU A 165
 None
 1.03A 4n48A-3girA:
undetectable		 4n48A-3girA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3gir AMINOMETHYLTRANSFERA
SE
(Bartonella
henselae) 		5 / 12 GLY A 180
GLY A  91
ILE A 202
GLY A 172
LEU A 165
 None
 1.08A 4n48A-3girA:
undetectable		 4n48A-3girA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 3gir AMINOMETHYLTRANSFERA
SE
(Bartonella
henselae) 		3 / 3 ARG A  94
THR A 258
TRP A 259
 None
 1.19A 4ug5A-3girA:
undetectable		 4ug5A-3girA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 3gir AMINOMETHYLTRANSFERA
SE
(Bartonella
henselae) 		3 / 3 ARG A  94
THR A 258
TRP A 259
 None
 1.17A 4uglA-3girA:
undetectable		 4uglA-3girA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 3gir AMINOMETHYLTRANSFERA
SE
(Bartonella
henselae) 		4 / 7 PHE A 277
LEU A  99
SER A 280
VAL A 261
 None
 1.04A 4wnvD-3girA:
undetectable		 4wnvD-3girA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 3gir AMINOMETHYLTRANSFERA
SE
(Bartonella
henselae) 		3 / 3 ARG A  94
THR A 258
TRP A 259
 None
 1.23A 5g6cA-3girA:
undetectable		 5g6cA-3girA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 3gir AMINOMETHYLTRANSFERA
SE
(Bartonella
henselae) 		4 / 7 ASP A 245
GLY A 321
SER A 319
VAL A 330
 None
 0.95A 6ekzA-3girA:
undetectable		 6ekzA-3girA:
12.53