SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3git'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		3 / 3 TRP A 427
VAL A 430
TRP A 418
 None
None
GOL  A 743 (-2.9A)
 1.18A 1c4dA-3gitA:
undetectable
1c4dB-3gitA:
undetectable		 1c4dA-3gitA:
3.93
1c4dB-3gitA:
3.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		5 / 12 TYR A 413
LEU A 417
LEU A 448
TYR A 444
ILE A 447
 None
 1.38A 1fmlA-3gitA:
undetectable		 1fmlA-3gitA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		3 / 4 VAL A 567
TRP A 533
TRP A 564
 None
 1.41A 1gmkA-3gitA:
undetectable
1gmkB-3gitA:
undetectable		 1gmkA-3gitA:
3.93
1gmkB-3gitA:
3.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 5 SER A 511
PHE A 512
GLU A 329
GLY A 330
 None
H2S  A 740 ( 4.6A)
None
None
 0.88A 1icvC-3gitA:
undetectable
1icvD-3gitA:
undetectable		 1icvC-3gitA:
18.97
1icvD-3gitA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 5 GLU A 329
GLY A 330
SER A 511
PHE A 512
 None
None
None
H2S  A 740 ( 4.6A)
 0.87A 1icvC-3gitA:
undetectable
1icvD-3gitA:
undetectable		 1icvC-3gitA:
18.97
1icvD-3gitA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 6 GLU A 329
GLY A 330
SER A 511
PHE A 512
 None
None
None
H2S  A 740 ( 4.6A)
 0.85A 1kqbC-3gitA:
undetectable
1kqbD-3gitA:
undetectable		 1kqbC-3gitA:
19.44
1kqbD-3gitA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 8 THR A 622
PRO A 623
SER A 624
ALA A 603
 None
 0.97A 2v32A-3gitA:
undetectable
2v32B-3gitA:
undetectable		 2v32A-3gitA:
19.95
2v32B-3gitA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		5 / 11 ILE A 664
LEU A 674
ILE A 667
ILE A 647
PHE A 657
 None
 1.05A 2w9sA-3gitA:
undetectable		 2w9sA-3gitA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		5 / 11 ILE A 664
LEU A 674
ILE A 667
ILE A 647
PHE A 657
 None
 1.07A 2w9sB-3gitA:
undetectable		 2w9sB-3gitA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		5 / 10 ILE A 664
LEU A 674
ILE A 667
ILE A 647
PHE A 657
 None
 1.09A 2w9sC-3gitA:
undetectable		 2w9sC-3gitA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		3 / 3 TYR A 714
GLU A 702
ASP A 617
 None
 0.79A 3bxoA-3gitA:
undetectable		 3bxoA-3gitA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		5 / 9 THR A 641
LEU A 584
SER A 505
ILE A 635
GLY A 637
 None
 1.12A 3cv9A-3gitA:
undetectable		 3cv9A-3gitA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		5 / 12 SER A 594
PHE A 677
PHE A 628
ILE A 635
ILE A 658
 None
 1.07A 3nxuA-3gitA:
undetectable		 3nxuA-3gitA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		5 / 12 SER A 594
PHE A 677
PHE A 628
ILE A 635
ILE A 658
 None
 1.04A 3nxuB-3gitA:
undetectable		 3nxuB-3gitA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 5 LEU A 587
ALA A 603
MET A 729
PHE A 644
 None
 1.35A 3uq6A-3gitA:
undetectable		 3uq6A-3gitA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 5 LEU A 587
ALA A 603
MET A 729
PHE A 644
 None
 1.33A 3vasB-3gitA:
undetectable		 3vasB-3gitA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		3 / 3 ASP A 497
ARG A 685
THR A 521
 None
 0.77A 4i13A-3gitA:
undetectable		 4i13A-3gitA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		3 / 3 ASP A 617
TRP A 669
SER A 673
 None
 1.04A 4lrhB-3gitA:
undetectable		 4lrhB-3gitA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		3 / 3 ASP A 617
TRP A 669
SER A 673
 None
 1.04A 4lrhF-3gitA:
undetectable		 4lrhF-3gitA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		3 / 3 ASP A 497
ARG A 685
THR A 521
 None
 0.74A 4p3rA-3gitA:
undetectable		 4p3rA-3gitA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 6 ARG A 488
ASP A 489
VAL A 531
ASP A 535
 None
None
SF4  A 738 (-4.2A)
None
 0.92A 4xqeA-3gitA:
undetectable		 4xqeA-3gitA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 6 ARG A 488
ASP A 489
VAL A 531
ASP A 535
 None
None
SF4  A 738 (-4.2A)
None
 0.88A 4xqeB-3gitA:
undetectable		 4xqeB-3gitA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 8 ARG A 488
ASP A 489
VAL A 531
ASP A 535
 None
None
SF4  A 738 (-4.2A)
None
 0.88A 4xqgA-3gitA:
undetectable		 4xqgA-3gitA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 8 ARG A 488
ASP A 489
VAL A 531
ASP A 535
 None
None
SF4  A 738 (-4.2A)
None
 0.89A 4xqgB-3gitA:
undetectable		 4xqgB-3gitA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 7 TYR A 413
PHE A 410
GLU A 455
GLU A 454
 None
 1.40A 4xzkA-3gitA:
undetectable		 4xzkA-3gitA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		3 / 3 ARG A 406
LYS A 451
GLU A 455
 None
 0.80A 5d0yA-3gitA:
undetectable		 5d0yA-3gitA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		5 / 12 GLU A 702
THR A 703
ILE A 704
GLY A 705
ILE A 711
 None
 1.18A 5ifuA-3gitA:
undetectable		 5ifuA-3gitA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		3 / 3 ARG A 685
ILE A 652
PHE A 657
 None
 0.69A 5kirA-3gitA:
undetectable		 5kirA-3gitA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		5 / 12 GLY A 638
ILE A 635
CYH A 506
LEU A 527
GLY A 646
 None
None
SF4  A 738 (-2.3A)
SF4  A 738 (-4.0A)
None
 1.46A 6bp4B-3gitA:
undetectable		 6bp4B-3gitA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		5 / 10 GLY A 610
ASN A 609
ALA A 722
PRO A 721
GLY A 662
 None
 1.12A 6e5zA-3gitA:
undetectable		 6e5zA-3gitA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		5 / 10 GLY A 610
ASN A 609
ALA A 722
PRO A 721
GLY A 663
 None
 1.12A 6e5zA-3gitA:
undetectable		 6e5zA-3gitA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		 3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		5 / 12 VAL A 653
GLU A 404
GLN A 422
GLU A 599
GLY A 648
 None
 1.34A 6gnfC-3gitA:
undetectable		 6gnfC-3gitA:
22.24