SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3giu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 3giu PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Staphylococcus
aureus) 		5 / 12 HIS A 103
ASP A 105
GLY A 149
HIS A 147
HIS A 143
 None
 1.34A 1a4lD-3giuA:
undetectable		 1a4lD-3giuA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3giu PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Staphylococcus
aureus) 		4 / 8 ILE A  66
VAL A 116
MET A 119
SER A 122
 None
 1.14A 1kb9A-3giuA:
undetectable
1kb9C-3giuA:
undetectable
1kb9D-3giuA:
undetectable
1kb9E-3giuA:
undetectable		 1kb9A-3giuA:
19.06
1kb9C-3giuA:
20.05
1kb9D-3giuA:
21.37
1kb9E-3giuA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 3giu PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Staphylococcus
aureus) 		5 / 12 THR A  42
GLY A  67
ARG A  72
HIS A 165
ILE A 169
 ACY  A 214 ( 3.5A)
ACY  A 214 (-3.6A)
None
ZN  A 213 (-3.5A)
None
 0.95A 2b25A-3giuA:
undetectable		 2b25A-3giuA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 3giu PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Staphylococcus
aureus) 		5 / 12 THR A  42
GLY A  67
ARG A  72
HIS A 165
ILE A 169
 ACY  A 214 ( 3.5A)
ACY  A 214 (-3.6A)
None
ZN  A 213 (-3.5A)
None
 1.09A 2b25B-3giuA:
undetectable		 2b25B-3giuA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 3giu PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Staphylococcus
aureus) 		5 / 12 HIS A 103
ASP A 105
GLY A 149
HIS A 147
HIS A 143
 None
 1.36A 2pgfA-3giuA:
undetectable		 2pgfA-3giuA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 3giu PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Staphylococcus
aureus) 		3 / 3 PHE A   8
ASN A  17
PHE A  11
 ACY  A 214 (-4.2A)
ACY  A 214 (-3.2A)
ACY  A 214 (-4.0A)
 1.07A 2zbuD-3giuA:
3.0		 2zbuD-3giuA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3giu PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Staphylococcus
aureus) 		5 / 10 ILE A  30
ILE A   3
VAL A  62
GLY A 162
LEU A 191
 None
 1.14A 3elzC-3giuA:
undetectable		 3elzC-3giuA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 3giu PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Staphylococcus
aureus) 		5 / 12 GLU A  78
PHE A 139
GLY A  67
PHE A   8
ASN A  17
 None
None
ACY  A 214 (-3.6A)
ACY  A 214 (-4.2A)
ACY  A 214 (-3.2A)
 1.33A 3ps9A-3giuA:
2.8		 3ps9A-3giuA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 3giu PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Staphylococcus
aureus) 		5 / 12 ILE A  35
LEU A 114
ILE A 164
PRO A  77
VAL A   5
 None
 1.08A 4kfjB-3giuA:
undetectable		 4kfjB-3giuA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 3giu PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Staphylococcus
aureus) 		4 / 7 ILE A  35
LEU A 191
LEU A  64
ILE A 198
 None
 0.82A 4rmjA-3giuA:
undetectable		 4rmjA-3giuA:
20.59