SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gjb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 3gjb CYTC3
(Streptomyces
sp.) 		5 / 11 ALA A 258
ARG A  40
LEU A  76
GLU A  79
ALA A  78
 None
 1.19A 1mjlA-3gjbA:
undetectable
1mjlB-3gjbA:
undetectable		 1mjlA-3gjbA:
18.97
1mjlB-3gjbA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 3gjb CYTC3
(Streptomyces
sp.) 		5 / 12 ASP A  88
GLU A  85
ALA A  78
ILE A  81
ARG A  40
 None
 1.28A 1s14B-3gjbA:
undetectable		 1s14B-3gjbA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 3gjb CYTC3
(Streptomyces
sp.) 		3 / 3 GLY A 280
GLU A 276
ASN A  64
 None
 0.70A 1zq9A-3gjbA:
undetectable		 1zq9A-3gjbA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3gjb CYTC3
(Streptomyces
sp.) 		5 / 12 LEU A 226
ALA A 258
ALA A 231
VAL A  29
PHE A  12
 None
 1.36A 3b0wB-3gjbA:
undetectable		 3b0wB-3gjbA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 3gjb CYTC3
(Streptomyces
sp.) 		5 / 9 LEU A 283
ALA A 288
ILE A 132
PRO A 269
THR A 271
 None
 1.19A 3spkA-3gjbA:
undetectable		 3spkA-3gjbA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I90_A_ACTA500_0
(1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE)		 3gjb CYTC3
(Streptomyces
sp.) 		3 / 3 LYS A 108
ARG A 253
TRP A 150
 AKG  A 321 (-2.4A)
AKG  A 321 (-3.4A)
None
 1.43A 4i90A-3gjbA:
undetectable		 4i90A-3gjbA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3gjb CYTC3
(Streptomyces
sp.) 		4 / 8 ILE A 281
LEU A  77
VAL A 289
ILE A  81
 None
 0.78A 4r38A-3gjbA:
undetectable		 4r38A-3gjbA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3gjb CYTC3
(Streptomyces
sp.) 		4 / 6 ILE A  74
ILE A  31
PHE A 256
PHE A  10
 None
 0.97A 5vkqB-3gjbA:
undetectable
5vkqC-3gjbA:
undetectable		 5vkqB-3gjbA:
10.54
5vkqC-3gjbA:
10.54