SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gjy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)
3gjy SPERMIDINE SYNTHASE
(Corynebacterium
glutamicum)
5 / 12 SER A 208
GLY A 205
VAL A 222
PHE A 279
MET A 228
None
1.48A 1a27A-3gjyA:
5.8
1a27A-3gjyA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)
3gjy SPERMIDINE SYNTHASE
(Corynebacterium
glutamicum)
4 / 8 ALA A 206
GLU A 209
LEU A 239
ARG A 162
None
0.71A 1ereE-3gjyA:
undetectable
1ereE-3gjyA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)
3gjy SPERMIDINE SYNTHASE
(Corynebacterium
glutamicum)
4 / 8 ALA A 206
GLU A 209
LEU A 239
ARG A 162
None
0.69A 1ereF-3gjyA:
undetectable
1ereF-3gjyA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)
3gjy SPERMIDINE SYNTHASE
(Corynebacterium
glutamicum)
4 / 8 GLY A  94
GLU A 117
LEU A 122
ASP A 144
None
FMT  A 315 (-3.6A)
FMT  A 315 (-4.0A)
None
0.61A 1jg4A-3gjyA:
8.8
1jg4A-3gjyA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)
3gjy SPERMIDINE SYNTHASE
(Corynebacterium
glutamicum)
4 / 5 ALA A 105
TYR A 108
ALA A 101
GLN A  83
None
1.13A 1xl6A-3gjyA:
undetectable
1xl6B-3gjyA:
undetectable
1xl6A-3gjyA:
22.95
1xl6B-3gjyA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)
3gjy SPERMIDINE SYNTHASE
(Corynebacterium
glutamicum)
3 / 3 GLY A  94
GLU A 117
ASP A 163
None
FMT  A 315 (-3.6A)
None
0.35A 2b25B-3gjyA:
11.0
2b25B-3gjyA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_B_AZZB1211_1
(DEOXYNUCLEOSIDE
KINASE)
3gjy SPERMIDINE SYNTHASE
(Corynebacterium
glutamicum)
5 / 12 GLU A 121
LEU A  33
PHE A 130
ARG A 124
ALA A 123
None
1.35A 2jj8B-3gjyA:
undetectable
2jj8B-3gjyA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)
3gjy SPERMIDINE SYNTHASE
(Corynebacterium
glutamicum)
5 / 12 GLU A 121
LEU A  33
PHE A 130
ARG A 124
ALA A 123
None
1.36A 2jj8C-3gjyA:
undetectable
2jj8C-3gjyA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_B_PPFB3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])
3gjy SPERMIDINE SYNTHASE
(Corynebacterium
glutamicum)
4 / 7 ARG A 204
HIS A 200
ASP A 199
ARG A 286
None
1.07A 2rk8B-3gjyA:
undetectable
2rk8B-3gjyA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)
3gjy SPERMIDINE SYNTHASE
(Corynebacterium
glutamicum)
3 / 3 ASP A 144
THR A  99
GLU A 117
None
None
FMT  A 315 (-3.6A)
0.58A 2zifB-3gjyA:
2.5
2zifB-3gjyA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)
3gjy SPERMIDINE SYNTHASE
(Corynebacterium
glutamicum)
5 / 12 GLY A 235
GLY A 198
ALA A 206
LEU A 203
VAL A 266
None
1.12A 2zulA-3gjyA:
12.1
2zulA-3gjyA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)
3gjy SPERMIDINE SYNTHASE
(Corynebacterium
glutamicum)
3 / 3 PHE A 179
CYH A 183
PHE A 152
None
1.12A 3cr5X-3gjyA:
undetectable
3cr5X-3gjyA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)
3gjy SPERMIDINE SYNTHASE
(Corynebacterium
glutamicum)
6 / 11 GLY A  94
GLU A 117
ASP A 119
LEU A 122
ASP A 144
ALA A 145
None
FMT  A 315 (-3.6A)
None
FMT  A 315 (-4.0A)
None
None
0.84A 3grvA-3gjyA:
3.1
3grvA-3gjyA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)
3gjy SPERMIDINE SYNTHASE
(Corynebacterium
glutamicum)
6 / 11 GLY A  94
GLY A  96
GLU A 117
LEU A 122
ASP A 144
ALA A 145
None
FMT  A 315 ( 4.2A)
FMT  A 315 (-3.6A)
FMT  A 315 (-4.0A)
None
None
1.00A 3grvA-3gjyA:
3.1
3grvA-3gjyA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)
3gjy SPERMIDINE SYNTHASE
(Corynebacterium
glutamicum)
6 / 12 GLY A  94
GLU A 117
ASP A 119
LEU A 122
ASP A 144
ALA A 145
None
FMT  A 315 (-3.6A)
None
FMT  A 315 (-4.0A)
None
None
0.79A 3gryA-3gjyA:
11.0
3gryA-3gjyA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)
3gjy SPERMIDINE SYNTHASE
(Corynebacterium
glutamicum)
6 / 12 GLY A  94
GLY A  96
GLU A 117
LEU A 122
ASP A 144
ALA A 145
None
FMT  A 315 ( 4.2A)
FMT  A 315 (-3.6A)
FMT  A 315 (-4.0A)
None
None
0.91A 3gryA-3gjyA:
11.0
3gryA-3gjyA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)
3gjy SPERMIDINE SYNTHASE
(Corynebacterium
glutamicum)
5 / 11 LEU A 239
GLU A 209
GLY A  94
HIS A  92
LEU A  93
None
1.34A 3hm1B-3gjyA:
undetectable
3hm1B-3gjyA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
3gjy SPERMIDINE SYNTHASE
(Corynebacterium
glutamicum)
5 / 11 GLY A  94
GLU A 117
ASP A 144
ALA A 145
ASP A 163
None
FMT  A 315 (-3.6A)
None
None
None
0.74A 3id5B-3gjyA:
10.3
3id5B-3gjyA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
3gjy SPERMIDINE SYNTHASE
(Corynebacterium
glutamicum)
5 / 11 GLY A  94
GLU A 117
ASP A 144
ALA A 145
ASP A 163
None
FMT  A 315 (-3.6A)
None
None
None
0.74A 3id5F-3gjyA:
10.3
3id5F-3gjyA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
3gjy SPERMIDINE SYNTHASE
(Corynebacterium
glutamicum)
5 / 12 GLY A  94
GLU A 117
ASP A 144
ALA A 145
ASP A 163
None
FMT  A 315 (-3.6A)
None
None
None
0.74A 3id6C-3gjyA:
10.3
3id6C-3gjyA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)
3gjy SPERMIDINE SYNTHASE
(Corynebacterium
glutamicum)
4 / 4 GLY A 235
TYR A 234
GLY A 198
ASP A 199
None
1.35A 3kl3A-3gjyA:
undetectable
3kl3A-3gjyA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)
3gjy SPERMIDINE SYNTHASE
(Corynebacterium
glutamicum)
4 / 4 GLY A  94
GLU A 117
ASP A 144
ASP A 163
None
FMT  A 315 (-3.6A)
None
None
0.66A 3mb5A-3gjyA:
13.9
3mb5A-3gjyA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)
3gjy SPERMIDINE SYNTHASE
(Corynebacterium
glutamicum)
5 / 12 GLY A  94
GLU A 117
ASP A 144
ALA A 145
ASP A 163
None
FMT  A 315 (-3.6A)
None
None
None
0.65A 3nmuA-3gjyA:
undetectable
3nmuF-3gjyA:
9.2
3nmuA-3gjyA:
21.61
3nmuF-3gjyA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
3gjy SPERMIDINE SYNTHASE
(Corynebacterium
glutamicum)
5 / 12 GLY A  94
ASP A 144
ALA A 145
ASP A 163
VAL A 164
None
0.92A 3nvkI-3gjyA:
12.0
3nvkI-3gjyA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)
3gjy SPERMIDINE SYNTHASE
(Corynebacterium
glutamicum)
6 / 12 GLY A  94
GLU A 117
ASP A 144
ALA A 145
ASP A 163
VAL A 164
None
FMT  A 315 (-3.6A)
None
None
None
None
0.98A 3nvkF-3gjyA:
undetectable
3nvkJ-3gjyA:
12.1
3nvkF-3gjyA:
21.27
3nvkJ-3gjyA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
3gjy SPERMIDINE SYNTHASE
(Corynebacterium
glutamicum)
5 / 12 GLY A  94
THR A  99
ALA A 145
ASP A 163
VAL A 164
None
0.65A 4df3A-3gjyA:
12.5
4df3A-3gjyA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
3gjy SPERMIDINE SYNTHASE
(Corynebacterium
glutamicum)
5 / 12 GLY A  94
THR A  99
ASP A 144
ALA A 145
ASP A 163
None
0.82A 4df3A-3gjyA:
12.5
4df3A-3gjyA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
3gjy SPERMIDINE SYNTHASE
(Corynebacterium
glutamicum)
5 / 12 GLY A  94
THR A  99
ALA A 145
ASP A 163
VAL A 164
None
0.70A 4df3B-3gjyA:
12.2
4df3B-3gjyA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
3gjy SPERMIDINE SYNTHASE
(Corynebacterium
glutamicum)
5 / 12 GLY A  94
THR A  99
ASP A 144
ALA A 145
ASP A 163
None
0.85A 4df3B-3gjyA:
12.2
4df3B-3gjyA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)
3gjy SPERMIDINE SYNTHASE
(Corynebacterium
glutamicum)
5 / 9 VAL A  50
GLU A  32
VAL A  30
ILE A  47
ALA A 166
None
1.14A 4fwdA-3gjyA:
undetectable
4fwdA-3gjyA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)
3gjy SPERMIDINE SYNTHASE
(Corynebacterium
glutamicum)
3 / 3 GLU A 117
ASP A 119
ASP A 144
FMT  A 315 (-3.6A)
None
None
0.63A 4gc9A-3gjyA:
8.7
4gc9A-3gjyA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)
3gjy SPERMIDINE SYNTHASE
(Corynebacterium
glutamicum)
5 / 12 GLY A  94
GLY A  95
GLY A  96
LEU A 118
ALA A 145
None
FMT  A 315 (-4.3A)
FMT  A 315 ( 4.2A)
None
None
0.78A 4htfA-3gjyA:
12.8
4htfA-3gjyA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)
3gjy SPERMIDINE SYNTHASE
(Corynebacterium
glutamicum)
5 / 12 GLY A  94
GLY A  95
GLY A  96
LEU A 118
ALA A 145
None
FMT  A 315 (-4.3A)
FMT  A 315 ( 4.2A)
None
None
0.80A 4htfB-3gjyA:
12.9
4htfB-3gjyA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)
3gjy SPERMIDINE SYNTHASE
(Corynebacterium
glutamicum)
5 / 12 ALA A 166
GLY A 167
ILE A  47
ASN A  48
GLY A  96
None
None
None
None
FMT  A 315 ( 4.2A)
1.32A 4obwD-3gjyA:
13.4
4obwD-3gjyA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)
3gjy SPERMIDINE SYNTHASE
(Corynebacterium
glutamicum)
4 / 6 ASN A 113
ILE A 160
ILE A 161
VAL A 194
None
0.94A 4olmA-3gjyA:
undetectable
4olmA-3gjyA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_E_SPME202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)
3gjy SPERMIDINE SYNTHASE
(Corynebacterium
glutamicum)
4 / 5 GLU A 121
GLU A  27
TYR A  28
GLU A 117
None
None
None
FMT  A 315 (-3.6A)
1.49A 4r87E-3gjyA:
1.4
4r87E-3gjyA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)
3gjy SPERMIDINE SYNTHASE
(Corynebacterium
glutamicum)
5 / 12 VAL A 177
CYH A 197
LEU A 239
ALA A 195
ALA A 206
None
1.24A 4x1kA-3gjyA:
2.5
4x1kB-3gjyA:
2.0
4x1kA-3gjyA:
19.91
4x1kB-3gjyA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)
3gjy SPERMIDINE SYNTHASE
(Corynebacterium
glutamicum)
5 / 12 ALA A 206
GLU A 209
LEU A 239
ARG A 162
LEU A 203
None
1.20A 4zn7A-3gjyA:
undetectable
4zn7A-3gjyA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_1
(ADENOSINE KINASE)
3gjy SPERMIDINE SYNTHASE
(Corynebacterium
glutamicum)
5 / 12 LEU A 210
GLY A 235
ALA A 206
LEU A 239
GLY A 231
None
0.89A 5kb5A-3gjyA:
4.2
5kb5A-3gjyA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)
3gjy SPERMIDINE SYNTHASE
(Corynebacterium
glutamicum)
4 / 7 ASN A 236
THR A  73
ILE A 238
GLY A  74
None
0.96A 5nzyA-3gjyA:
undetectable
5nzyA-3gjyA:
20.82