SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gk0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWH_A_PEMA501_1
(HEMOGLOBIN ALPHA
CHAIN)		 3gk0 PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Burkholderia
pseudomallei) 		4 / 6 ALA A 125
LYS A 128
ASP A 132
ALA A 133
 None
 0.46A 1iwhA-3gk0A:
undetectable		 1iwhA-3gk0A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 3gk0 PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Burkholderia
pseudomallei) 		4 / 8 VAL A  82
LEU A 114
SER A 138
VAL A 137
 None
 1.03A 1jtvA-3gk0A:
undetectable		 1jtvA-3gk0A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_2
(PROTEASE)		 3gk0 PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Burkholderia
pseudomallei) 		5 / 12 LEU A 213
ALA A 198
GLY A 164
ALA A 209
ILE A 210
 None
 0.96A 2nmyB-3gk0A:
undetectable		 2nmyB-3gk0A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)		 3gk0 PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Burkholderia
pseudomallei) 		6 / 12 LEU A 213
ALA A 198
ILE A 221
GLY A 201
ALA A 209
ILE A 210
 None
 1.39A 2nmzA-3gk0A:
undetectable		 2nmzA-3gk0A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_3
(PROTEASE)		 3gk0 PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Burkholderia
pseudomallei) 		6 / 12 LEU A 213
ALA A 198
ILE A 221
GLY A 201
ALA A 209
ILE A 210
 None
 1.33A 2nmzB-3gk0A:
undetectable		 2nmzB-3gk0A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 3gk0 PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Burkholderia
pseudomallei) 		5 / 12 ILE A 225
ALA A  46
ASN A  16
ILE A 216
ASN A 197
 None
 1.08A 2rlcA-3gk0A:
undetectable		 2rlcA-3gk0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 3gk0 PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Burkholderia
pseudomallei) 		5 / 10 ALA A 146
ALA A 150
THR A 154
LEU A 139
VAL A 123
 None
 1.32A 2wuzA-3gk0A:
undetectable		 2wuzA-3gk0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 3gk0 PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Burkholderia
pseudomallei) 		5 / 10 ALA A 146
ALA A 150
THR A 154
LEU A 139
VAL A 123
 None
 1.31A 2wuzB-3gk0A:
undetectable		 2wuzB-3gk0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA602_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 3gk0 PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Burkholderia
pseudomallei) 		4 / 7 ASN A  16
ALA A  38
ALA A  37
ALA A  41
 None
 0.59A 3a2qA-3gk0A:
undetectable		 3a2qA-3gk0A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_2
(PROTEASE)		 3gk0 PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Burkholderia
pseudomallei) 		5 / 12 ALA A 198
ILE A 221
GLY A 201
ALA A 209
ILE A 210
 None
 0.89A 3ekwB-3gk0A:
undetectable		 3ekwB-3gk0A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3gk0 PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Burkholderia
pseudomallei) 		5 / 12 MET A 245
ILE A 221
VAL A  15
LEU A  13
ALA A 237
 None
 1.32A 4m11A-3gk0A:
undetectable		 4m11A-3gk0A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3gk0 PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Burkholderia
pseudomallei) 		5 / 12 MET A 245
ILE A 221
VAL A  15
LEU A  13
ALA A 237
 None
 1.34A 4m11C-3gk0A:
undetectable		 4m11C-3gk0A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3gk0 PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Burkholderia
pseudomallei) 		5 / 12 MET A 245
ILE A 221
VAL A  15
LEU A  13
ALA A 237
 None
 1.30A 4m11D-3gk0A:
undetectable		 4m11D-3gk0A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 3gk0 PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Burkholderia
pseudomallei) 		5 / 10 LYS A 195
ILE A 159
ILE A 141
VAL A 116
ALA A 126
 None
 1.20A 5nukA-3gk0A:
undetectable		 5nukA-3gk0A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 3gk0 PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Burkholderia
pseudomallei) 		4 / 6 HIS A  19
VAL A 226
LEU A  23
THR A  22
 None
 1.08A 5ogjA-3gk0A:
undetectable		 5ogjA-3gk0A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_B_ACTB305_0
(CARBONIC ANHYDRASE
13)		 3gk0 PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Burkholderia
pseudomallei) 		4 / 6 HIS A  19
VAL A 226
LEU A  23
THR A  22
 None
 1.07A 5ogjB-3gk0A:
undetectable		 5ogjB-3gk0A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 3gk0 PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Burkholderia
pseudomallei) 		4 / 5 HIS A  19
VAL A 226
LEU A  23
THR A  22
 None
 1.08A 5ohhA-3gk0A:
undetectable		 5ohhA-3gk0A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_B_ACTB311_0
(CARBONIC ANHYDRASE
13)		 3gk0 PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Burkholderia
pseudomallei) 		4 / 6 HIS A  19
VAL A 226
LEU A  23
THR A  22
 None
 1.09A 5ohhB-3gk0A:
undetectable		 5ohhB-3gk0A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_E_EZLE303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3gk0 PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Burkholderia
pseudomallei) 		5 / 9 HIS A 223
HIS A  19
VAL A 226
LEU A  23
THR A  22
 None
 1.46A 5tt3E-3gk0A:
undetectable		 5tt3E-3gk0A:
20.07