SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gk3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 3gk3 ACETOACETYL-COA
REDUCTASE
(Burkholderia
pseudomallei) 		3 / 3 LEU A 222
SER A 183
ASN A 138
 None
 0.66A 1bx4A-3gk3A:
6.6		 1bx4A-3gk3A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 3gk3 ACETOACETYL-COA
REDUCTASE
(Burkholderia
pseudomallei) 		5 / 11 SER A 141
VAL A 142
GLY A 144
TYR A 154
GLY A 185
 PO4  A 249 (-2.7A)
None
None
PO4  A 249 (-4.6A)
PO4  A 249 (-4.8A)
 1.15A 1iolA-3gk3A:
26.9		 1iolA-3gk3A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 3gk3 ACETOACETYL-COA
REDUCTASE
(Burkholderia
pseudomallei) 		4 / 8 GLY A  15
GLY A  14
LEU A  16
SER A  21
 None
 0.60A 1qzzA-3gk3A:
6.4		 1qzzA-3gk3A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 3gk3 ACETOACETYL-COA
REDUCTASE
(Burkholderia
pseudomallei) 		4 / 7 MET A 128
ALA A 126
ILE A 125
ILE A 136
 None
 0.83A 1upfB-3gk3A:
3.2		 1upfB-3gk3A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 3gk3 ACETOACETYL-COA
REDUCTASE
(Burkholderia
pseudomallei) 		4 / 7 GLY A  12
THR A  10
MET A  13
SER A  36
 None
 1.27A 2o5yH-3gk3A:
undetectable
2o5yL-3gk3A:
undetectable		 2o5yH-3gk3A:
21.03
2o5yL-3gk3A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 3gk3 ACETOACETYL-COA
REDUCTASE
(Burkholderia
pseudomallei) 		3 / 3 ASP A 115
ASN A 119
THR A  10
 None
 0.68A 2pymB-3gk3A:
undetectable		 2pymB-3gk3A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 3gk3 ACETOACETYL-COA
REDUCTASE
(Burkholderia
pseudomallei) 		3 / 3 ASP A 115
ASN A 119
THR A  10
 None
 0.72A 2q63B-3gk3A:
undetectable		 2q63B-3gk3A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3gk3 ACETOACETYL-COA
REDUCTASE
(Burkholderia
pseudomallei) 		5 / 10 ILE A 177
GLY A 176
PHE A 133
GLY A 232
THR A 235
 None
 1.40A 2y7wB-3gk3A:
undetectable		 2y7wB-3gk3A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 3gk3 ACETOACETYL-COA
REDUCTASE
(Burkholderia
pseudomallei) 		5 / 12 GLN A 207
TYR A 154
GLY A 185
ILE A 208
GLY A 214
 None
PO4  A 249 (-4.6A)
PO4  A 249 (-4.8A)
None
None
 0.96A 3bwcA-3gk3A:
5.0		 3bwcA-3gk3A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 3gk3 ACETOACETYL-COA
REDUCTASE
(Burkholderia
pseudomallei) 		4 / 8 LEU A 205
ILE A 208
ASN A 242
GLY A 185
 None
None
None
PO4  A 249 (-4.8A)
 0.90A 3wxoA-3gk3A:
undetectable		 3wxoA-3gk3A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 3gk3 ACETOACETYL-COA
REDUCTASE
(Burkholderia
pseudomallei) 		4 / 8 ASP A 115
ASN A 119
THR A  10
GLY A  91
 None
 0.97A 4fo4A-3gk3A:
undetectable		 4fo4A-3gk3A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3gk3 ACETOACETYL-COA
REDUCTASE
(Burkholderia
pseudomallei) 		4 / 7 VAL A 210
ILE A 208
LEU A  16
LEU A 187
 None
 0.89A 4xo7A-3gk3A:
undetectable		 4xo7A-3gk3A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 3gk3 ACETOACETYL-COA
REDUCTASE
(Burkholderia
pseudomallei) 		5 / 12 HIS A 162
LEU A 239
VAL A 137
GLY A  91
MET A 117
 None
 1.12A 5byjA-3gk3A:
2.4		 5byjA-3gk3A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 3gk3 ACETOACETYL-COA
REDUCTASE
(Burkholderia
pseudomallei) 		4 / 8 ARG A 215
ILE A  20
ALA A  19
LEU A  16
 None
 0.74A 5te8B-3gk3A:
undetectable		 5te8B-3gk3A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 3gk3 ACETOACETYL-COA
REDUCTASE
(Burkholderia
pseudomallei) 		5 / 12 GLY A 150
TYR A 154
ASN A 143
ALA A 148
ASP A 113
 None
PO4  A 249 (-4.6A)
PO4  A 249 ( 4.2A)
None
None
 1.15A 6b3aA-3gk3A:
2.9		 6b3aA-3gk3A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 3gk3 ACETOACETYL-COA
REDUCTASE
(Burkholderia
pseudomallei) 		5 / 12 GLY A 150
TYR A 154
ASN A 143
ALA A 148
ASP A 113
 None
PO4  A 249 (-4.6A)
PO4  A 249 ( 4.2A)
None
None
 1.15A 6b3bA-3gk3A:
5.3		 6b3bA-3gk3A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 3gk3 ACETOACETYL-COA
REDUCTASE
(Burkholderia
pseudomallei) 		5 / 12 GLY A 185
VAL A 210
LEU A 187
ALA A 188
LEU A  16
 PO4  A 249 (-4.8A)
None
None
None
None
 1.01A 6bq4A-3gk3A:
6.7		 6bq4A-3gk3A:
15.08