SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gkf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_A_ADNA252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 3gkf ALDOLASE LSRF
(Escherichia
coli) 		5 / 9 HIS O 150
ILE O 153
ASN O 155
SER O 152
GLN O 151
 None
 1.23A 2a8tA-3gkfO:
0.0		 2a8tA-3gkfO:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 3gkf ALDOLASE LSRF
(Escherichia
coli) 		5 / 11 LEU O  78
LEU O  54
VAL O  84
ILE O  75
PHE O  56
 None
 1.26A 2q6hA-3gkfO:
undetectable		 2q6hA-3gkfO:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 3gkf ALDOLASE LSRF
(Escherichia
coli) 		5 / 11 LEU O  78
LEU O  54
VAL O  84
ILE O  75
PHE O  56
 None
 1.27A 2qeiA-3gkfO:
undetectable		 2qeiA-3gkfO:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB830_1
(ALPHA-AMYLASE, SUSG)		 3gkf ALDOLASE LSRF
(Escherichia
coli) 		4 / 5 ARG O 185
TYR O 186
LYS O 182
ASP O 183
 None
 1.27A 3k8mB-3gkfO:
7.9		 3k8mB-3gkfO:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 3gkf ALDOLASE LSRF
(Escherichia
coli) 		3 / 3 ALA O 122
VAL O 123
GLN O 158
 None
 0.67A 3of4B-3gkfO:
undetectable		 3of4B-3gkfO:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 3gkf ALDOLASE LSRF
(Escherichia
coli) 		5 / 12 CYH O 239
ALA O 235
SER O 259
VAL O 250
ALA O 268
 None
 1.15A 3qxvE-3gkfO:
undetectable		 3qxvE-3gkfO:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 3gkf ALDOLASE LSRF
(Escherichia
coli) 		3 / 3 VAL O  52
GLY O 249
LYS O  50
 None
 0.74A 4k50A-3gkfO:
undetectable		 4k50A-3gkfO:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 3gkf ALDOLASE LSRF
(Escherichia
coli) 		3 / 3 VAL O  52
GLY O 249
LYS O  50
 None
 0.70A 4k50E-3gkfO:
undetectable		 4k50E-3gkfO:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 3gkf ALDOLASE LSRF
(Escherichia
coli) 		3 / 3 ARG O 107
TYR O 143
GLU O 121
 None
 0.69A 4zzbE-3gkfO:
undetectable		 4zzbE-3gkfO:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3gkf ALDOLASE LSRF
(Escherichia
coli) 		5 / 12 GLY O 110
PHE O  61
GLY O  59
LEU O  68
GLY O 175
 None
 1.07A 5i75A-3gkfO:
undetectable		 5i75A-3gkfO:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3gkf ALDOLASE LSRF
(Escherichia
coli) 		4 / 7 VAL O 131
ARG O  39
VAL O 138
GLY O 163
 None
 1.01A 5x80C-3gkfO:
undetectable
5x80D-3gkfO:
undetectable		 5x80C-3gkfO:
19.73
5x80D-3gkfO:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3gkf ALDOLASE LSRF
(Escherichia
coli) 		3 / 3 GLN O 241
TRP O 240
VAL O 272
 None
 0.93A 6auuA-3gkfO:
undetectable		 6auuA-3gkfO:
20.65