SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gkj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)		 3gkj NIEMANN-PICK C1
PROTEIN
(Homo
sapiens) 		4 / 5 PHE A 101
LEU A 173
MET A 156
LEU A 111
 None
 1.18A 1skxA-3gkjA:
undetectable		 1skxA-3gkjA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 3gkj NIEMANN-PICK C1
PROTEIN
(Homo
sapiens) 		4 / 7 LEU A  87
GLN A  88
PHE A 101
LEU A 105
 None
 0.96A 3ag2C-3gkjA:
undetectable		 3ag2C-3gkjA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3gkj NIEMANN-PICK C1
PROTEIN
(Homo
sapiens) 		4 / 7 LEU A  87
GLN A  88
PHE A 101
LEU A 105
 None
 0.96A 3ag2P-3gkjA:
undetectable
3ag2W-3gkjA:
undetectable		 3ag2P-3gkjA:
19.23
3ag2W-3gkjA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3gkj NIEMANN-PICK C1
PROTEIN
(Homo
sapiens) 		4 / 8 LEU A  87
GLN A  88
PHE A 101
LEU A 105
 None
 0.93A 3ag4C-3gkjA:
undetectable
3ag4J-3gkjA:
undetectable		 3ag4C-3gkjA:
19.23
3ag4J-3gkjA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3gkj NIEMANN-PICK C1
PROTEIN
(Homo
sapiens) 		4 / 7 LEU A  87
GLN A  88
PHE A 101
LEU A 105
 None
 0.93A 3ag4P-3gkjA:
undetectable
3ag4W-3gkjA:
undetectable		 3ag4P-3gkjA:
19.23
3ag4W-3gkjA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3gkj NIEMANN-PICK C1
PROTEIN
(Homo
sapiens) 		4 / 7 LEU A  87
GLN A  88
PHE A 101
LEU A 105
 None
 0.96A 3asnC-3gkjA:
undetectable
3asnJ-3gkjA:
undetectable		 3asnC-3gkjA:
19.23
3asnJ-3gkjA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 3gkj NIEMANN-PICK C1
PROTEIN
(Homo
sapiens) 		4 / 8 ASN A 198
LYS A 196
PRO A 207
PHE A 209
 HC3  A 253 ( 3.8A)
None
None
None
 1.39A 3bjwD-3gkjA:
undetectable		 3bjwD-3gkjA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3gkj NIEMANN-PICK C1
PROTEIN
(Homo
sapiens) 		4 / 7 LEU A  87
GLN A  88
PHE A 101
LEU A 105
 None
 0.94A 3x2qC-3gkjA:
undetectable
3x2qJ-3gkjA:
undetectable		 3x2qC-3gkjA:
19.23
3x2qJ-3gkjA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 3gkj NIEMANN-PICK C1
PROTEIN
(Homo
sapiens) 		3 / 3 ASN A 103
LEU A 173
PHE A 101
 None
 0.81A 4dajB-3gkjA:
undetectable		 4dajB-3gkjA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3gkj NIEMANN-PICK C1
PROTEIN
(Homo
sapiens) 		4 / 7 LEU A  87
GLN A  88
PHE A 101
LEU A 105
 None
 0.99A 5b3sC-3gkjA:
undetectable
5b3sJ-3gkjA:
undetectable		 5b3sC-3gkjA:
19.23
5b3sJ-3gkjA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 3gkj NIEMANN-PICK C1
PROTEIN
(Homo
sapiens) 		4 / 7 LEU A  87
GLN A  88
PHE A 101
LEU A 105
 None
 1.00A 5b3sP-3gkjA:
undetectable		 5b3sP-3gkjA:
19.23