SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gkq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 3gkq TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE
(Sphingomonas
sp.
KA1) 		5 / 10 ILE A 290
ASN A 173
LEU A  52
GLY A  53
ALA A  24
 None
 1.44A 1ju6C-3gkqA:
undetectable		 1ju6C-3gkqA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 3gkq TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE
(Sphingomonas
sp.
KA1) 		5 / 11 ILE A 290
ASN A 173
LEU A  52
GLY A  53
ALA A  24
 None
 1.45A 1ju6D-3gkqA:
undetectable		 1ju6D-3gkqA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3gkq TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE
(Sphingomonas
sp.
KA1) 		4 / 7 LEU A 327
LEU A 195
LEU A 281
GLN A 283
 None
 0.96A 1kt3A-3gkqA:
undetectable		 1kt3A-3gkqA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 3gkq TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE
(Sphingomonas
sp.
KA1) 		3 / 3 VAL A  61
VAL A  65
TRP A 102
 None
 0.99A 1w5uA-3gkqA:
undetectable
1w5uB-3gkqA:
undetectable		 1w5uA-3gkqA:
7.61
1w5uB-3gkqA:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 3gkq TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE
(Sphingomonas
sp.
KA1) 		5 / 10 ALA A 370
GLN A 378
LEU A  52
SER A 371
ARG A 175
 None
 1.38A 2ceoB-3gkqA:
undetectable		 2ceoB-3gkqA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3gkq TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE
(Sphingomonas
sp.
KA1) 		4 / 8 ILE A 364
GLU A 179
ILE A 363
GLU A 354
 None
 0.98A 2j9dJ-3gkqA:
0.7
2j9dK-3gkqA:
0.7
2j9dL-3gkqA:
undetectable		 2j9dJ-3gkqA:
16.45
2j9dK-3gkqA:
16.45
2j9dL-3gkqA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 3gkq TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE
(Sphingomonas
sp.
KA1) 		4 / 6 LEU A 296
MET A 300
LEU A 135
VAL A 129
 None
 1.18A 4okbA-3gkqA:
undetectable		 4okbA-3gkqA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 3gkq TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE
(Sphingomonas
sp.
KA1) 		5 / 12 LEU A  51
LEU A  52
GLY A  53
GLN A 378
ARG A  29
 None
 1.16A 4olmA-3gkqA:
undetectable		 4olmA-3gkqA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 3gkq TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE
(Sphingomonas
sp.
KA1) 		3 / 3 ARG A 175
GLU A 354
TYR A  21
 None
 0.92A 4r29D-3gkqA:
undetectable		 4r29D-3gkqA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 3gkq TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE
(Sphingomonas
sp.
KA1) 		5 / 12 ALA A 362
ASP A 230
GLU A 365
LEU A 215
PRO A 209
 None
 1.20A 4xi3A-3gkqA:
undetectable		 4xi3A-3gkqA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3gkq TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE
(Sphingomonas
sp.
KA1) 		5 / 12 GLY A 198
LEU A 281
PHE A 314
LEU A 327
PHE A 276
 None
 1.11A 4ze1A-3gkqA:
undetectable		 4ze1A-3gkqA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3gkq TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE
(Sphingomonas
sp.
KA1) 		4 / 8 ILE A 194
GLY A 329
PHE A 240
PHE A 188
 None
 0.95A 5hieD-3gkqA:
undetectable		 5hieD-3gkqA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 3gkq TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE
(Sphingomonas
sp.
KA1) 		4 / 6 ASP A  23
ARG A  29
ASN A  30
GLN A 378
 None
 1.15A 5l6eA-3gkqA:
undetectable		 5l6eA-3gkqA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 3gkq TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE
(Sphingomonas
sp.
KA1) 		4 / 5 PRO A  34
VAL A 288
GLY A 376
VAL A 140
 None
 1.05A 6ak3B-3gkqA:
undetectable		 6ak3B-3gkqA:
12.63