SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gku'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 3gku PROBABLE RNA-BINDING
PROTEIN
([Clostridium]
symbiosum) 		5 / 10 ALA A  63
LEU A 111
LEU A 114
LEU A  67
LEU A 134
 None
 1.01A 2riwA-3gkuA:
undetectable
2riwB-3gkuA:
undetectable		 2riwA-3gkuA:
22.64
2riwB-3gkuA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3gku PROBABLE RNA-BINDING
PROTEIN
([Clostridium]
symbiosum) 		4 / 6 VAL A 201
VAL A 188
ILE A 154
ARG A 176
 None
 1.02A 3mssA-3gkuA:
undetectable		 3mssA-3gkuA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3gku PROBABLE RNA-BINDING
PROTEIN
([Clostridium]
symbiosum) 		4 / 6 VAL A 201
VAL A 188
ILE A 154
ARG A 176
 None
 0.99A 3mssC-3gkuA:
undetectable		 3mssC-3gkuA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3gku PROBABLE RNA-BINDING
PROTEIN
([Clostridium]
symbiosum) 		4 / 6 VAL A 201
VAL A 188
ILE A 154
ARG A 176
 None
 0.93A 3pyyA-3gkuA:
undetectable		 3pyyA-3gkuA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 3gku PROBABLE RNA-BINDING
PROTEIN
([Clostridium]
symbiosum) 		4 / 7 ASN A 153
LEU A 182
MET A 170
LEU A 147
 None
 1.01A 4okwA-3gkuA:
undetectable		 4okwA-3gkuA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3gku PROBABLE RNA-BINDING
PROTEIN
([Clostridium]
symbiosum) 		4 / 6 LEU A 167
TYR A 139
GLN A 115
GLU A 174
 None
 1.39A 6djzC-3gkuA:
undetectable		 6djzC-3gkuA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 3gku PROBABLE RNA-BINDING
PROTEIN
([Clostridium]
symbiosum) 		3 / 3 ASP A 193
SER A 204
SER A 164
 None
 0.67A 6mxtA-3gkuA:
undetectable		 6mxtA-3gkuA:
19.07