SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gle'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 3gle PILIN
(Streptococcus
pyogenes) 		3 / 3 THR A  84
PRO A  48
THR A  50
 THR  A  84 ( 0.8A)
PRO  A  48 ( 1.1A)
THR  A  50 ( 0.8A)
 0.86A 1dscC-3gleA:
undetectable		 1dscC-3gleA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3gle PILIN
(Streptococcus
pyogenes) 		4 / 7 PHE A 194
ALA A 227
VAL A 210
VAL A 245
 PHE  A 194 ( 1.3A)
ALA  A 227 ( 0.0A)
VAL  A 210 ( 0.6A)
VAL  A 245 ( 0.5A)
 0.60A 1epbA-3gleA:
undetectable		 1epbA-3gleA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3gle PILIN
(Streptococcus
pyogenes) 		4 / 8 PHE A 194
ALA A 227
VAL A 210
VAL A 245
 PHE  A 194 ( 1.3A)
ALA  A 227 ( 0.0A)
VAL  A 210 ( 0.6A)
VAL  A 245 ( 0.5A)
 0.63A 1epbB-3gleA:
undetectable		 1epbB-3gleA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_C_DVAC8_0
(ACTINOMYCIN D)		 3gle PILIN
(Streptococcus
pyogenes) 		3 / 3 THR A  50
THR A  84
PRO A  48
 THR  A  50 ( 0.8A)
THR  A  84 ( 0.8A)
PRO  A  48 ( 1.1A)
 0.79A 1fjaC-3gleA:
undetectable		 1fjaC-3gleA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_D_DVAD8_0
(ACTINOMYCIN D)		 3gle PILIN
(Streptococcus
pyogenes) 		3 / 3 THR A  50
THR A  84
PRO A  48
 THR  A  50 ( 0.8A)
THR  A  84 ( 0.8A)
PRO  A  48 ( 1.1A)
 0.79A 1fjaD-3gleA:
undetectable		 1fjaD-3gleA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 3gle PILIN
(Streptococcus
pyogenes) 		4 / 7 GLU A 117
TYR A 128
THR A  50
TYR A  83
 GLU  A 117 ( 0.6A)
TYR  A 128 ( 1.3A)
THR  A  50 ( 0.8A)
TYR  A  83 ( 1.3A)
 1.24A 1rmtB-3gleA:
undetectable		 1rmtB-3gleA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 3gle PILIN
(Streptococcus
pyogenes) 		3 / 3 THR A  50
THR A  84
PRO A  48
 THR  A  50 ( 0.8A)
THR  A  84 ( 0.8A)
PRO  A  48 ( 1.1A)
 0.81A 209dC-3gleA:
undetectable		 209dC-3gleA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 3gle PILIN
(Streptococcus
pyogenes) 		3 / 3 GLY A 186
ARG A 188
TYR A 266
 GLY  A 186 ( 0.0A)
ARG  A 188 ( 0.6A)
TYR  A 266 ( 1.3A)
 0.69A 2opxA-3gleA:
undetectable		 2opxA-3gleA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 3gle PILIN
(Streptococcus
pyogenes) 		3 / 3 THR A  84
PRO A  48
THR A  50
 THR  A  84 ( 0.8A)
PRO  A  48 ( 1.1A)
THR  A  50 ( 0.8A)
 0.81A 316dC-3gleA:
undetectable		 316dC-3gleA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3gle PILIN
(Streptococcus
pyogenes) 		6 / 12 LEU A 198
LEU A 175
VAL A 177
ILE A 212
PHE A 235
THR A 287
 LEU  A 198 ( 0.6A)
LEU  A 175 ( 0.5A)
VAL  A 177 ( 0.6A)
ILE  A 212 ( 0.7A)
PHE  A 235 ( 1.3A)
THR  A 287 ( 0.8A)
 1.42A 3fl9G-3gleA:
undetectable		 3fl9G-3gleA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3gle PILIN
(Streptococcus
pyogenes) 		5 / 9 LEU A 175
VAL A 177
ILE A 212
PHE A 235
THR A 287
 LEU  A 175 ( 0.5A)
VAL  A 177 ( 0.6A)
ILE  A 212 ( 0.7A)
PHE  A 235 ( 1.3A)
THR  A 287 ( 0.8A)
 1.28A 3fl9H-3gleA:
undetectable		 3fl9H-3gleA:
17.63