SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3glg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 3glg DNA POLYMERASE III
SUBUNIT DELTA'
(Escherichia
coli) 		3 / 3 ASP E 314
LEU E 311
HIS E 333
 None
 0.69A 1qknA-3glgE:
undetectable		 1qknA-3glgE:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 3glg DNA POLYMERASE III
SUBUNIT DELTA
(Escherichia
coli) 		3 / 3 ASP A  27
GLU A 239
ARG A 228
 None
 0.86A 1wopA-3glgA:
undetectable		 1wopA-3glgA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 3glg DNA POLYMERASE III
SUBUNIT DELTA
(Escherichia
coli) 		4 / 6 LEU A 324
LEU A 304
LEU A 305
LEU A 331
 None
 0.67A 2ab2A-3glgA:
undetectable		 2ab2A-3glgA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 3glg DNA POLYMERASE III
SUBUNIT DELTA'
(Escherichia
coli) 		4 / 8 ARG E 158
LEU E 132
LEU E  79
VAL E  93
 None
 1.00A 2bdmA-3glgE:
undetectable		 2bdmA-3glgE:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 3glg DNA POLYMERASE III
SUBUNIT DELTA'
(Escherichia
coli) 		4 / 8 TYR E  47
LEU E  48
GLU E 138
ALA E 109
 None
 0.77A 2bnnA-3glgE:
undetectable
2bnnB-3glgE:
undetectable		 2bnnA-3glgE:
20.69
2bnnB-3glgE:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 3glg DNA POLYMERASE III
SUBUNIT DELTA'
(Escherichia
coli) 		4 / 7 GLY E 108
GLY E 107
VAL E 111
LEU E  49
 None
 0.80A 2oa1B-3glgE:
undetectable		 2oa1B-3glgE:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3glg DNA POLYMERASE III
SUBUNIT DELTA
(Escherichia
coli) 		5 / 12 ALA A  70
LEU A 100
LEU A  82
PHE A  53
SER A  54
 None
 1.27A 2oipB-3glgA:
undetectable		 2oipB-3glgA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3glg DNA POLYMERASE III
SUBUNIT DELTA
(Escherichia
coli) 		5 / 12 ALA A  70
LEU A 100
LEU A  82
PHE A  53
SER A  54
 None
 1.17A 2oipC-3glgA:
undetectable		 2oipC-3glgA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z9X_A_PXLA1503_1
(ASPARTATE
AMINOTRANSFERASE)		 3glg DNA POLYMERASE III
SUBUNIT DELTA
(Escherichia
coli) 		5 / 10 PRO A 243
VAL A 244
THR A 311
VAL A 320
SER A 319
 None
 1.36A 2z9xA-3glgA:
1.3		 2z9xA-3glgA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z9X_B_PXLB2503_1
(ASPARTATE
AMINOTRANSFERASE)		 3glg DNA POLYMERASE III
SUBUNIT DELTA
(Escherichia
coli) 		5 / 11 PRO A 243
VAL A 244
LEU A 247
VAL A 320
SER A 319
 None
 0.84A 2z9xB-3glgA:
1.3		 2z9xB-3glgA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z9X_B_PXLB2503_1
(ASPARTATE
AMINOTRANSFERASE)		 3glg DNA POLYMERASE III
SUBUNIT DELTA
(Escherichia
coli) 		5 / 11 PRO A 243
VAL A 244
THR A 311
VAL A 320
SER A 319
 None
 1.34A 2z9xB-3glgA:
1.3		 2z9xB-3glgA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 3glg DNA POLYMERASE III
SUBUNIT DELTA'
(Escherichia
coli) 		4 / 5 VAL E 112
VAL E 111
THR E 131
THR E  78
 None
 1.17A 3bjwA-3glgE:
1.1		 3bjwA-3glgE:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 3glg DNA POLYMERASE III
SUBUNIT DELTA'
(Escherichia
coli) 		4 / 5 VAL E 112
VAL E 111
THR E 131
THR E  78
 None
 1.19A 3bjwG-3glgE:
undetectable		 3bjwG-3glgE:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_1
(PHOSPHOLIPASE A2)		 3glg DNA POLYMERASE III
SUBUNIT DELTA'
(Escherichia
coli) 		4 / 5 VAL E 112
VAL E 111
THR E 131
THR E  78
 None
 1.17A 3bjwC-3glgE:
1.1		 3bjwC-3glgE:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 3glg DNA POLYMERASE III
SUBUNIT DELTA'
(Escherichia
coli) 		4 / 5 VAL E 112
VAL E 111
THR E 131
THR E  78
 None
 1.19A 3bjwD-3glgE:
1.1		 3bjwD-3glgE:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 3glg DNA POLYMERASE III
SUBUNIT DELTA'
(Escherichia
coli) 		4 / 5 LEU E 164
ASP E  37
ILE E  29
GLY E  36
 None
 0.96A 3bufA-3glgE:
undetectable		 3bufA-3glgE:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3glg DNA POLYMERASE III
SUBUNIT DELTA
(Escherichia
coli) 		5 / 12 ALA A  70
LEU A 100
LEU A  82
PHE A  53
SER A  54
 None
 1.20A 3hj3C-3glgA:
undetectable		 3hj3C-3glgA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 3glg DNA POLYMERASE III
SUBUNIT DELTA'
(Escherichia
coli) 		4 / 8 ALA E 243
ARG E 244
ASN E 209
LEU E 204
 None
 0.79A 3hrdA-3glgE:
undetectable
3hrdB-3glgE:
undetectable		 3hrdA-3glgE:
21.41
3hrdB-3glgE:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 3glg DNA POLYMERASE III
SUBUNIT DELTA
(Escherichia
coli) 		4 / 6 LEU A 257
LEU A 298
LEU A 327
LEU A 330
 None
 1.08A 3q1eA-3glgA:
undetectable
3q1eC-3glgA:
undetectable		 3q1eA-3glgA:
18.50
3q1eC-3glgA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3glg DNA POLYMERASE III
SUBUNIT DELTA
(Escherichia
coli) 		5 / 12 VAL A 151
LEU A 162
VAL A 206
ALA A 184
LEU A 185
 None
 1.07A 3rr3A-3glgA:
undetectable		 3rr3A-3glgA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3glg DNA POLYMERASE III
SUBUNIT DELTA
(Escherichia
coli) 		5 / 12 VAL A 151
LEU A 162
VAL A 206
ALA A 184
LEU A 185
 None
 1.07A 3rr3B-3glgA:
undetectable		 3rr3B-3glgA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 3glg DNA POLYMERASE III
SUBUNIT DELTA
(Escherichia
coli) 		5 / 11 LEU A  81
THR A  79
SER A  34
LEU A  22
VAL A 135
 None
 1.36A 3tbgA-3glgA:
2.2		 3tbgA-3glgA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3glg DNA POLYMERASE III
SUBUNIT DELTA'
(Escherichia
coli) 		4 / 5 LEU E  40
ARG E   8
PRO E 198
SER E 197
 None
 1.48A 4kmmB-3glgE:
undetectable		 4kmmB-3glgE:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 3glg DNA POLYMERASE III
SUBUNIT DELTA
(Escherichia
coli) 		5 / 12 LEU A 236
LEU A 233
LEU A 230
ALA A 229
LEU A 250
 None
 1.18A 4ltwA-3glgA:
undetectable		 4ltwA-3glgA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 3glg DNA POLYMERASE III
SUBUNIT DELTA
(Escherichia
coli) 		4 / 4 HIS A 231
GLU A 239
HIS A 211
LEU A 178
 None
 1.43A 4m2rA-3glgA:
undetectable		 4m2rA-3glgA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 3glg DNA POLYMERASE III
SUBUNIT DELTA
(Escherichia
coli) 		5 / 12 LEU A  13
ASN A  14
GLY A  16
LEU A 109
GLN A  40
 None
 0.82A 4p6xA-3glgA:
undetectable		 4p6xA-3glgA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 3glg DNA POLYMERASE III
SUBUNIT DELTA
(Escherichia
coli) 		5 / 12 LEU A  13
ASN A  14
GLY A  16
LEU A 109
GLN A  40
 None
 0.80A 4p6xE-3glgA:
undetectable		 4p6xE-3glgA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 3glg DNA POLYMERASE III
SUBUNIT DELTA
(Escherichia
coli) 		5 / 12 LEU A  13
ASN A  14
GLY A  16
LEU A 109
GLN A  40
 None
 0.86A 4p6xI-3glgA:
undetectable		 4p6xI-3glgA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMH_A_EF2A151_1
(CEREBLON ISOFORM 4)		 3glg DNA POLYMERASE III
SUBUNIT DELTA'
(Escherichia
coli) 		4 / 7 PRO E 135
PHE E 141
TRP E 140
TYR E  18
 None
 1.49A 5amhA-3glgE:
undetectable		 5amhA-3glgE:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 3glg DNA POLYMERASE III
SUBUNIT DELTA
(Escherichia
coli) 		3 / 3 VAL A 151
GLN A 168
CYH A 171
 None
 0.77A 5icxA-3glgA:
undetectable
5icxE-3glgA:
undetectable		 5icxA-3glgA:
20.93
5icxE-3glgA:
4.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 3glg DNA POLYMERASE III
SUBUNIT DELTA'
(Escherichia
coli) 		5 / 12 LEU E 286
TRP E 229
LEU E 316
LEU E 252
LEU E 216
 None
 1.22A 5ienB-3glgE:
undetectable		 5ienB-3glgE:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 3glg DNA POLYMERASE III
SUBUNIT DELTA'
(Escherichia
coli) 		4 / 8 ILE E 289
LEU E 236
ILE E 312
LEU E 277
 None
 0.99A 5ieoA-3glgE:
undetectable		 5ieoA-3glgE:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3glg DNA POLYMERASE III
SUBUNIT DELTA
(Escherichia
coli) 		5 / 12 PRO A  89
VAL A 112
ALA A  19
ALA A  20
LEU A 104
 None
 1.23A 5igpA-3glgA:
undetectable		 5igpA-3glgA:
22.49