SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gme'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_1
(MINERALOCORTICOID
RECEPTOR)		 3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Escherichia
coli) 		5 / 12 LEU A 202
ALA A 526
GLN A 525
LEU A 468
MET A 491
 None
 1.49A 1ya3A-3gmeA:
undetectable		 1ya3A-3gmeA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Escherichia
coli) 		4 / 6 ALA A 441
SER A 439
PHE A 343
ILE A 464
 None
 0.99A 1yc2A-3gmeA:
undetectable		 1yc2A-3gmeA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOA_A_3TCA302_1
(DEOXYCYTIDINE KINASE)		 3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Escherichia
coli) 		5 / 12 GLU A 198
LEU A 505
MET A 507
PHE A 493
ALA A 526
 None
 1.50A 2noaA-3gmeA:
undetectable		 2noaA-3gmeA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		 3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Escherichia
coli) 		5 / 12 VAL A 427
GLY A 339
ALA A 407
PHE A 378
ILE A 541
 None
 0.92A 2v0zO-3gmeA:
undetectable		 2v0zO-3gmeA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Escherichia
coli) 		4 / 7 VAL A  33
ILE A 132
ALA A 136
VAL A  31
 None
 0.76A 2xrzB-3gmeA:
undetectable		 2xrzB-3gmeA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA2_0
(FERROCHELATASE)		 3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Escherichia
coli) 		4 / 6 MET A 415
ARG A 426
PRO A 544
GLY A 339
 None
 1.48A 3aqiA-3gmeA:
undetectable		 3aqiA-3gmeA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB4_0
(FERROCHELATASE)		 3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Escherichia
coli) 		4 / 6 MET A 415
ARG A 426
PRO A 544
GLY A 339
 None
 1.48A 3aqiB-3gmeA:
undetectable		 3aqiB-3gmeA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Escherichia
coli) 		5 / 12 GLY A 155
ALA A 204
MET A 201
LEU A 170
GLU A 172
 None
 1.02A 3ckkA-3gmeA:
undetectable		 3ckkA-3gmeA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Escherichia
coli) 		5 / 10 ILE A 324
ILE A 464
VAL A 495
GLY A 497
ARG A 499
 None
 1.19A 3elzC-3gmeA:
1.6		 3elzC-3gmeA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Escherichia
coli) 		5 / 10 SER A 437
LEU A 327
ILE A 533
SER A 442
GLY A 463
 None
 1.08A 3ik6B-3gmeA:
undetectable
3ik6E-3gmeA:
undetectable		 3ik6B-3gmeA:
18.38
3ik6E-3gmeA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Escherichia
coli) 		5 / 12 ILE A 533
GLY A 528
ALA A 496
ALA A 462
CYH A 444
 None
 0.98A 3sufD-3gmeA:
undetectable		 3sufD-3gmeA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_A_MIYA2001_1
(TETX2 PROTEIN)		 3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Escherichia
coli) 		5 / 11 GLY A 436
SER A 434
PHE A 382
GLY A 404
ASN A 381
 None
 1.17A 3v3nA-3gmeA:
undetectable		 3v3nA-3gmeA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_D_MIYD2001_1
(TETX2 PROTEIN)		 3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Escherichia
coli) 		5 / 11 GLY A 436
SER A 434
PHE A 382
GLY A 404
ASN A 381
 None
 1.16A 3v3nD-3gmeA:
undetectable		 3v3nD-3gmeA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Escherichia
coli) 		3 / 3 ARG A 325
ASP A 492
GLN A 506
 None
MN  A 550 (-3.6A)
None
 0.91A 4azsA-3gmeA:
undetectable		 4azsA-3gmeA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CUT_A_TYLA2971_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Escherichia
coli) 		4 / 4 VAL A  16
VAL A 215
ASN A 164
ILE A 128
 None
 1.43A 4cutA-3gmeA:
undetectable		 4cutA-3gmeA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Escherichia
coli) 		4 / 7 ILE A 533
LEU A 448
GLY A 445
PHE A 343
 None
 0.92A 4iqqA-3gmeA:
undetectable		 4iqqA-3gmeA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Escherichia
coli) 		5 / 12 ILE A 216
ASP A 127
ILE A 128
ARG A 153
ILE A 149
 None
 1.03A 4m2xA-3gmeA:
undetectable		 4m2xA-3gmeA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Escherichia
coli) 		5 / 12 ILE A 216
ASP A 127
ILE A 128
ARG A 153
ILE A 149
 None
 1.00A 4m2xE-3gmeA:
undetectable		 4m2xE-3gmeA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Escherichia
coli) 		5 / 12 ALA A 449
GLY A 339
LEU A 334
GLY A 332
VAL A 333
 None
 0.94A 4o3fA-3gmeA:
undetectable		 4o3fA-3gmeA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Escherichia
coli) 		5 / 12 LEU A 482
GLU A 485
ARG A 315
ILE A 533
GLY A 463
 None
 1.11A 5gtrA-3gmeA:
undetectable		 5gtrA-3gmeA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Escherichia
coli) 		4 / 8 ILE A  99
PRO A  98
MET A 188
ILE A  91
 None
 0.86A 5ieoA-3gmeA:
undetectable		 5ieoA-3gmeA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Escherichia
coli) 		4 / 4 VAL A 215
VAL A 214
TYR A  11
GLN A  10
 None
 1.46A 5qggA-3gmeA:
undetectable		 5qggA-3gmeA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGO_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Escherichia
coli) 		4 / 4 VAL A 215
VAL A 214
TYR A  11
GLN A  10
 None
 1.43A 5qgoA-3gmeA:
undetectable		 5qgoA-3gmeA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGP_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Escherichia
coli) 		4 / 4 VAL A 215
VAL A 214
TYR A  11
GLN A  10
 None
 1.45A 5qgpA-3gmeA:
undetectable		 5qgpA-3gmeA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGQ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Escherichia
coli) 		4 / 4 VAL A 215
VAL A 214
TYR A  11
GLN A  10
 None
 1.48A 5qgqA-3gmeA:
undetectable		 5qgqA-3gmeA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHB_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Escherichia
coli) 		4 / 4 VAL A 215
VAL A 214
TYR A  11
GLN A  10
 None
 1.45A 5qhbA-3gmeA:
undetectable		 5qhbA-3gmeA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Escherichia
coli) 		4 / 8 PHE A 343
LEU A 342
LEU A 448
ALA A 449
 None
 0.79A 5y7pE-3gmeA:
undetectable		 5y7pE-3gmeA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Escherichia
coli) 		4 / 8 ILE A 114
GLN A 112
VAL A  61
THR A  89
 MN  A 551 (-4.6A)
None
None
None
 1.04A 6cduG-3gmeA:
undetectable
6cduH-3gmeA:
undetectable		 6cduG-3gmeA:
24.08
6cduH-3gmeA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Escherichia
coli) 		5 / 10 SER A 437
LEU A 327
ILE A 533
SER A 442
GLY A 463
 None
 1.22A 6dlzA-3gmeA:
undetectable
6dlzD-3gmeA:
undetectable		 6dlzA-3gmeA:
10.86
6dlzD-3gmeA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Escherichia
coli) 		5 / 10 ILE A 533
SER A 442
GLY A 463
SER A 437
LEU A 327
 None
 1.22A 6dlzB-3gmeA:
undetectable
6dlzC-3gmeA:
undetectable		 6dlzB-3gmeA:
10.86
6dlzC-3gmeA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Escherichia
coli) 		5 / 10 SER A 437
LEU A 327
ILE A 533
SER A 442
GLY A 463
 None
 1.22A 6dm1A-3gmeA:
undetectable
6dm1D-3gmeA:
undetectable		 6dm1A-3gmeA:
10.86
6dm1D-3gmeA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Escherichia
coli) 		5 / 10 ILE A 533
SER A 442
GLY A 463
SER A 437
LEU A 327
 None
 1.23A 6dm1B-3gmeA:
undetectable
6dm1C-3gmeA:
undetectable		 6dm1B-3gmeA:
10.86
6dm1C-3gmeA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Escherichia
coli) 		4 / 6 ILE A 401
ALA A  92
ARG A  93
ASP A 508
 None
 1.13A 6hu9m-3gmeA:
undetectable
6hu9q-3gmeA:
undetectable		 6hu9m-3gmeA:
22.51
6hu9q-3gmeA:
14.77