SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gmi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		4 / 8 SER A  81
VAL A  82
TYR A  59
MET A 121
 None
 0.98A 1fduB-3gmiA:
undetectable		 1fduB-3gmiA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKJ_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		5 / 11 PHE A 137
VAL A  82
TYR A  59
HIS A  66
PHE A  79
 None
 1.38A 1fkjA-3gmiA:
undetectable		 1fkjA-3gmiA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		6 / 10 LEU A 312
ILE A 123
GLY A 125
PRO A 289
VAL A 292
ILE A 324
 None
None
MLI  A 401 (-3.3A)
None
None
None
 1.37A 1hsgA-3gmiA:
undetectable		 1hsgA-3gmiA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		6 / 9 LEU A 312
ILE A 123
GLY A 125
PRO A 289
VAL A 292
ILE A 324
 None
None
MLI  A 401 (-3.3A)
None
None
None
 1.39A 1ohrB-3gmiA:
undetectable		 1ohrB-3gmiA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		4 / 6 ARG A 270
TYR A 340
ASP A  24
GLU A 329
 None
 1.23A 1rjdA-3gmiA:
undetectable		 1rjdA-3gmiA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		4 / 6 ARG A 270
TYR A 340
ASP A  24
GLU A 329
 None
 1.24A 1rjdB-3gmiA:
undetectable		 1rjdB-3gmiA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		4 / 6 ARG A 270
TYR A 340
ASP A  24
GLU A 329
 None
 1.26A 1rjdC-3gmiA:
undetectable		 1rjdC-3gmiA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_1
(PROTEASE RETROPEPSIN)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		5 / 10 LEU A  62
GLY A 111
ALA A 112
ASP A 113
GLY A  73
 None
 0.92A 1t3rA-3gmiA:
undetectable		 1t3rA-3gmiA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_1
(POL POLYPROTEIN)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		5 / 10 LEU A  62
GLY A 111
ALA A 112
ASP A 113
GLY A  73
 None
 0.91A 1t7iA-3gmiA:
undetectable		 1t7iA-3gmiA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		4 / 5 GLU A 256
THR A 250
LEU A 254
LEU A 251
 None
 1.23A 1u18B-3gmiA:
undetectable		 1u18B-3gmiA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FKE_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		5 / 11 PHE A 137
VAL A  82
TYR A  59
HIS A  66
PHE A  79
 None
 1.40A 2fkeA-3gmiA:
undetectable		 2fkeA-3gmiA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A 150
GLY A  65
GLU A 223
HIS A  66
GLY A 224
 None
 1.33A 2fn1A-3gmiA:
undetectable		 2fn1A-3gmiA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A 150
GLY A  65
GLU A 223
HIS A  66
GLY A 224
 None
 1.30A 2fn1B-3gmiA:
undetectable		 2fn1B-3gmiA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_1
(POL PROTEIN)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		5 / 11 LEU A  62
GLY A 111
ALA A 112
ASP A 113
GLY A  73
 None
 0.78A 2fxdA-3gmiA:
undetectable		 2fxdA-3gmiA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_2
(PROTEASE)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		5 / 9 LEU A  62
GLY A 111
ALA A 112
ASP A 113
GLY A  73
 None
 0.93A 2idwB-3gmiA:
undetectable		 2idwB-3gmiA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_1
(PROTEASE)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  62
GLY A 111
ALA A 112
ASP A 113
GLY A  73
 None
 0.83A 2ieoA-3gmiA:
undetectable		 2ieoA-3gmiA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  62
GLY A 111
ALA A 112
ASP A 113
GLY A  73
 None
 0.87A 2q63A-3gmiA:
undetectable		 2q63A-3gmiA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  62
GLY A 111
ALA A 112
ASP A 113
GLY A  73
 None
 0.86A 2qakA-3gmiA:
undetectable		 2qakA-3gmiA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_2
(PROTEASE RETROPEPSIN)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  62
GLY A 111
ALA A 112
ASP A 113
GLY A  73
 None
 0.88A 2rkfB-3gmiA:
undetectable		 2rkfB-3gmiA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		4 / 7 GLU A  20
TYR A 101
ARG A 100
GLU A 117
 None
 1.22A 2zt7A-3gmiA:
undetectable		 2zt7A-3gmiA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 162
LEU A 184
ILE A 175
PHE A 218
MET A 198
 None
 1.00A 3b2rA-3gmiA:
undetectable		 3b2rA-3gmiA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		3 / 3 LYS A  72
LYS A 220
VAL A 219
 None
 0.93A 3brfA-3gmiA:
undetectable		 3brfA-3gmiA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_1
(PROTEASE)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		5 / 11 LEU A  62
GLY A 111
ALA A 112
ASP A 113
GLY A  73
 None
 0.87A 3ektC-3gmiA:
undetectable		 3ektC-3gmiA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_2
(PROTEASE)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		5 / 9 LEU A  62
GLY A 111
ALA A 112
ASP A 113
GLY A  73
 None
 0.86A 3gguB-3gmiA:
undetectable		 3gguB-3gmiA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		3 / 3 SER A 226
GLY A 227
THR A 228
 None
 0.12A 3k9wA-3gmiA:
11.7		 3k9wA-3gmiA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_1
(HIV-1 PROTEASE)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		5 / 10 LEU A  62
GLY A 111
ALA A 112
ASP A 113
GLY A  73
 None
 0.90A 3lzvA-3gmiA:
undetectable		 3lzvA-3gmiA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		4 / 6 PHE A  79
THR A  57
ALA A 110
ALA A 107
 None
 1.14A 3ns1C-3gmiA:
undetectable		 3ns1C-3gmiA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		5 / 9 GLY A 111
ALA A 112
ASP A 113
ILE A  80
GLY A  73
 None
 0.92A 3ogpA-3gmiA:
undetectable		 3ogpA-3gmiA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		5 / 9 GLY A 111
ALA A 112
ASP A 113
ILE A  80
GLY A  73
 None
 1.01A 3ogpB-3gmiA:
undetectable		 3ogpB-3gmiA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		5 / 10 LEU A  62
GLY A 111
ALA A 112
ASP A 113
GLY A  73
 None
 0.87A 3oxwA-3gmiA:
undetectable		 3oxwA-3gmiA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		5 / 10 LEU A  62
GLY A 111
ALA A 112
ASP A 113
GLY A  73
 None
 0.87A 3oxwC-3gmiA:
undetectable		 3oxwC-3gmiA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_2
(PROTEASE)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  62
GLY A 111
ALA A 112
ASP A 113
GLY A  73
 None
 0.84A 3s54B-3gmiA:
undetectable		 3s54B-3gmiA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_1
(POL POLYPROTEIN)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		5 / 9 LEU A  62
GLY A 111
ALA A 112
ASP A 113
GLY A  73
 None
 0.92A 3u7sA-3gmiA:
undetectable		 3u7sA-3gmiA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		4 / 5 GLU A 182
GLY A 181
TYR A 166
GLU A 179
 None
 1.40A 3w9tA-3gmiA:
undetectable		 3w9tA-3gmiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		4 / 5 GLU A 182
GLY A 181
TYR A 166
GLU A 179
 None
 1.40A 3w9tC-3gmiA:
undetectable		 3w9tC-3gmiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		4 / 5 GLU A 182
GLY A 181
TYR A 166
GLU A 179
 None
 1.39A 3w9tD-3gmiA:
undetectable		 3w9tD-3gmiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		4 / 5 GLU A 182
GLY A 181
TYR A 166
GLU A 179
 None
 1.40A 3w9tG-3gmiA:
undetectable		 3w9tG-3gmiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_2
(ASPARTYL PROTEASE)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		5 / 9 LEU A  62
GLY A 111
ALA A 112
ASP A 113
GLY A  73
 None
 0.90A 4dqcB-3gmiA:
undetectable		 4dqcB-3gmiA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_2
(ASPARTYL PROTEASE)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		5 / 10 LEU A  62
GLY A 111
ALA A 112
ASP A 113
GLY A  73
 None
 0.90A 4dqfB-3gmiA:
undetectable		 4dqfB-3gmiA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_2
(PROTEASE)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		5 / 10 LEU A  62
GLY A 111
ALA A 112
ASP A 113
GLY A  73
 None
 0.88A 4ll3B-3gmiA:
undetectable		 4ll3B-3gmiA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_1
(PROTEASE)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		5 / 10 LEU A  62
GLY A 111
ALA A 112
ASP A 113
GLY A  73
 None
 0.86A 4ll3A-3gmiA:
undetectable		 4ll3A-3gmiA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_1
(ASPARTYL PROTEASE)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		5 / 11 LEU A  62
GLY A 111
ALA A 112
ASP A 113
GLY A  73
 None
 0.91A 4q1xA-3gmiA:
undetectable		 4q1xA-3gmiA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_1
(ASPARTYL PROTEASE)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		5 / 10 LEU A  62
GLY A 111
ALA A 112
ASP A 113
GLY A  73
 None
 0.91A 4q1yA-3gmiA:
undetectable		 4q1yA-3gmiA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		3 / 3 VAL A 170
TYR A 193
ALA A 196
 None
 0.57A 4ybnA-3gmiA:
undetectable		 4ybnA-3gmiA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		4 / 4 CYH A  54
PHE A  79
ILE A  43
GLY A  77
 None
 1.44A 5hesB-3gmiA:
undetectable		 5hesB-3gmiA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		4 / 7 GLY A 111
ALA A 112
ASP A 113
GLY A  73
 None
 0.57A 5kqyB-3gmiA:
undetectable		 5kqyB-3gmiA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_2
(PROTEASE PR5-DRV)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		4 / 8 GLY A 111
ALA A 112
ASP A 113
GLY A  73
 None
 0.61A 5kr1B-3gmiA:
undetectable		 5kr1B-3gmiA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Q1S_A_AWYA1103_0
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		4 / 6 LYS A 354
VAL A  40
ILE A  52
LYS A  49
 None
 1.49A 5q1sA-3gmiA:
undetectable		 5q1sA-3gmiA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		4 / 6 VAL A  40
ILE A  78
GLU A  47
ARG A  46
 None
 1.02A 5z3jA-3gmiA:
undetectable		 5z3jA-3gmiA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_1
(HIV-1 PROTEASE)		 3gmi UPF0348 PROTEIN
MJ0951
(Methanocaldococc
us
jannaschii) 		6 / 12 LEU A 312
ILE A 123
GLY A 125
PRO A 289
VAL A 292
ILE A 324
 None
None
MLI  A 401 (-3.3A)
None
None
None
 1.44A 6dilB-3gmiA:
undetectable		 6dilB-3gmiA:
12.43