SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gms'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 3gms PUTATIVE
NADPH:QUINONE
REDUCTASE
(Bacillus
thuringiensis) 		3 / 3 ALA A 130
VAL A 132
TRP A 131
 None
 0.79A 1bdwA-3gmsA:
undetectable
1bdwB-3gmsA:
undetectable		 1bdwA-3gmsA:
6.78
1bdwB-3gmsA:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 3gms PUTATIVE
NADPH:QUINONE
REDUCTASE
(Bacillus
thuringiensis) 		5 / 12 VAL A 132
LEU A 238
THR A 129
HIS A 265
TRP A 250
 None
 1.37A 1kw0A-3gmsA:
undetectable		 1kw0A-3gmsA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3gms PUTATIVE
NADPH:QUINONE
REDUCTASE
(Bacillus
thuringiensis) 		5 / 12 GLY A 241
SER A 218
ILE A 216
ILE A 263
LEU A 238
 None
 1.03A 1kyvA-3gmsA:
2.2
1kyvE-3gmsA:
undetectable		 1kyvA-3gmsA:
20.48
1kyvE-3gmsA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3gms PUTATIVE
NADPH:QUINONE
REDUCTASE
(Bacillus
thuringiensis) 		5 / 12 ILE A 263
LEU A 238
GLY A 241
SER A 218
ILE A 216
 None
 1.03A 1kyvB-3gmsA:
2.3
1kyvC-3gmsA:
2.2		 1kyvB-3gmsA:
20.48
1kyvC-3gmsA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3gms PUTATIVE
NADPH:QUINONE
REDUCTASE
(Bacillus
thuringiensis) 		5 / 12 ILE A 263
LEU A 238
GLY A 241
SER A 218
ILE A 216
 None
 1.05A 1kyvC-3gmsA:
2.2
1kyvD-3gmsA:
undetectable		 1kyvC-3gmsA:
20.48
1kyvD-3gmsA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3gms PUTATIVE
NADPH:QUINONE
REDUCTASE
(Bacillus
thuringiensis) 		5 / 12 ILE A 263
LEU A 238
GLY A 241
SER A 218
ILE A 216
 None
 1.05A 1kyvD-3gmsA:
undetectable
1kyvE-3gmsA:
undetectable		 1kyvD-3gmsA:
20.48
1kyvE-3gmsA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 3gms PUTATIVE
NADPH:QUINONE
REDUCTASE
(Bacillus
thuringiensis) 		4 / 6 LEU A 162
PHE A 159
ALA A 160
LEU A 294
 None
 0.89A 1ukbA-3gmsA:
2.4		 1ukbA-3gmsA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 3gms PUTATIVE
NADPH:QUINONE
REDUCTASE
(Bacillus
thuringiensis) 		5 / 11 SER A 153
LEU A 146
ALA A 130
ARG A 185
GLU A 182
 None
 1.41A 2v0mA-3gmsA:
undetectable		 2v0mA-3gmsA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 3gms PUTATIVE
NADPH:QUINONE
REDUCTASE
(Bacillus
thuringiensis) 		4 / 7 LEU A 146
LEU A 170
PHE A 168
LEU A 138
 None
 0.75A 2vq5B-3gmsA:
undetectable		 2vq5B-3gmsA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 3gms PUTATIVE
NADPH:QUINONE
REDUCTASE
(Bacillus
thuringiensis) 		3 / 3 ARG A 175
GLU A 182
SER A 218
 None
 0.84A 2xkkA-3gmsA:
3.4
2xkkC-3gmsA:
2.5		 2xkkA-3gmsA:
19.43
2xkkC-3gmsA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3gms PUTATIVE
NADPH:QUINONE
REDUCTASE
(Bacillus
thuringiensis) 		4 / 7 SER A  45
ILE A 125
PRO A  64
GLY A  65
 None
 0.99A 2y7kA-3gmsA:
undetectable		 2y7kA-3gmsA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3gms PUTATIVE
NADPH:QUINONE
REDUCTASE
(Bacillus
thuringiensis) 		5 / 12 ASN A 149
LEU A 231
ILE A 216
LEU A 138
THR A 207
 None
 1.02A 3fl9B-3gmsA:
3.3		 3fl9B-3gmsA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3gms PUTATIVE
NADPH:QUINONE
REDUCTASE
(Bacillus
thuringiensis) 		5 / 11 ASN A 149
LEU A 231
ILE A 216
LEU A 138
THR A 207
 None
 0.99A 3fl9C-3gmsA:
3.3		 3fl9C-3gmsA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3gms PUTATIVE
NADPH:QUINONE
REDUCTASE
(Bacillus
thuringiensis) 		5 / 12 ASN A 149
LEU A 231
ILE A 216
LEU A 138
THR A 207
 None
 1.02A 3fl9G-3gmsA:
3.1		 3fl9G-3gmsA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3gms PUTATIVE
NADPH:QUINONE
REDUCTASE
(Bacillus
thuringiensis) 		4 / 6 TYR A 330
GLY A  68
THR A 328
GLU A  67
 None
 1.02A 3fpjA-3gmsA:
5.6		 3fpjA-3gmsA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 3gms PUTATIVE
NADPH:QUINONE
REDUCTASE
(Bacillus
thuringiensis) 		5 / 10 LEU A 227
LEU A 231
ILE A 216
LEU A 138
THR A 207
 None
 1.21A 3jw5B-3gmsA:
3.2		 3jw5B-3gmsA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 3gms PUTATIVE
NADPH:QUINONE
REDUCTASE
(Bacillus
thuringiensis) 		5 / 12 GLY A 245
GLY A 221
ASN A 249
SER A 244
LEU A 243
 None
 0.95A 4uciA-3gmsA:
3.9		 4uciA-3gmsA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 3gms PUTATIVE
NADPH:QUINONE
REDUCTASE
(Bacillus
thuringiensis) 		5 / 12 GLY A 245
GLY A 221
ASN A 249
SER A 244
LEU A 243
 None
 0.96A 4uciB-3gmsA:
4.0		 4uciB-3gmsA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 3gms PUTATIVE
NADPH:QUINONE
REDUCTASE
(Bacillus
thuringiensis) 		5 / 12 GLY A 245
GLY A 221
ASN A 249
SER A 244
LEU A 243
 None
 0.96A 4uckA-3gmsA:
3.9		 4uckA-3gmsA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 3gms PUTATIVE
NADPH:QUINONE
REDUCTASE
(Bacillus
thuringiensis) 		3 / 3 VAL A 132
PHE A 282
ARG A  92
 None
 0.84A 4xr4B-3gmsA:
4.7		 4xr4B-3gmsA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 3gms PUTATIVE
NADPH:QUINONE
REDUCTASE
(Bacillus
thuringiensis) 		4 / 8 LEU A 327
ASP A 307
ALA A 311
VAL A 314
 None
 0.82A 4zbqA-3gmsA:
undetectable		 4zbqA-3gmsA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 3gms PUTATIVE
NADPH:QUINONE
REDUCTASE
(Bacillus
thuringiensis) 		4 / 8 ASP A  46
GLY A  68
THR A  96
LEU A  89
 None
 0.97A 5hwaA-3gmsA:
undetectable		 5hwaA-3gmsA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3gms PUTATIVE
NADPH:QUINONE
REDUCTASE
(Bacillus
thuringiensis) 		4 / 4 GLN A 122
THR A 119
LEU A 162
LEU A 158
 None
 1.27A 5m5kB-3gmsA:
7.2		 5m5kB-3gmsA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3gms PUTATIVE
NADPH:QUINONE
REDUCTASE
(Bacillus
thuringiensis) 		4 / 8 VAL A 259
HIS A 236
GLY A 224
LEU A 227
 None
 0.90A 5w3jB-3gmsA:
2.4		 5w3jB-3gmsA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 3gms PUTATIVE
NADPH:QUINONE
REDUCTASE
(Bacillus
thuringiensis) 		4 / 6 TYR A 190
VAL A 173
VAL A 203
THR A 202
 None
 1.38A 6f32B-3gmsA:
4.1		 6f32B-3gmsA:
22.11