SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gmw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCL_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
N-ACETYL-D-HIS-L-PRO
-OH)		 3gmw BETA-LACTAMASE
INHIBITORY PROTEIN
BLIP-I
(Streptomyces
exfoliatus) 		4 / 5 TYR B  71
GLU B  70
PHE B  44
TYR B  50
 None
 1.09A 1mclA-3gmwB:
undetectable
1mclB-3gmwB:
undetectable
1mclP-3gmwB:
undetectable		 1mclA-3gmwB:
19.81
1mclB-3gmwB:
19.81
1mclP-3gmwB:
1.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3gmw BETA-LACTAMASE
INHIBITORY PROTEIN
BLIP-I
(Streptomyces
exfoliatus) 		3 / 3 THR B 132
SER B  79
LYS B  81
 None
 0.90A 3aocC-3gmwB:
undetectable		 3aocC-3gmwB:
9.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3gmw BETA-LACTAMASE
INHIBITORY PROTEIN
BLIP-I
(Streptomyces
exfoliatus) 		5 / 12 GLN B  11
GLU B   7
GLY B  25
ALA B  30
PHE B   4
 None
 1.26A 4retC-3gmwB:
undetectable		 4retC-3gmwB:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3gmw BETA-LACTAMASE
INHIBITORY PROTEIN
BLIP-I
(Streptomyces
exfoliatus) 		4 / 6 GLY B  62
GLU B  61
ASP B  19
ASP B  60
 None
PO4  B 158 (-2.7A)
None
PO4  B 158 (-3.3A)
 1.05A 4uckB-3gmwB:
undetectable		 4uckB-3gmwB:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 3gmw BETA-LACTAMASE
INHIBITORY PROTEIN
BLIP-I
(Streptomyces
exfoliatus) 		4 / 6 ALA B 139
SER B 140
ALA B 129
SER B 138
 None
PO4  B   1 (-2.3A)
None
None
 1.04A 6bocA-3gmwB:
undetectable
6bocB-3gmwB:
undetectable
6bocC-3gmwB:
undetectable
6bocD-3gmwB:
undetectable		 6bocA-3gmwB:
8.97
6bocB-3gmwB:
8.97
6bocC-3gmwB:
8.97
6bocD-3gmwB:
8.97