SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gn3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 3gn3 PUTATIVE
PROTEIN-DISULFIDE
ISOMERASE
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 6 PRO A 153
ASP A 169
ASP A 177
TRP A 174
 SO4  A 180 (-4.2A)
None
None
None
 1.28A 1hpkA-3gn3A:
undetectable		 1hpkA-3gn3A:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3gn3 PUTATIVE
PROTEIN-DISULFIDE
ISOMERASE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 VAL A  64
ALA A  69
ALA A  70
LEU A 122
ALA A 127
 None
 0.97A 3fc6C-3gn3A:
undetectable		 3fc6C-3gn3A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 3gn3 PUTATIVE
PROTEIN-DISULFIDE
ISOMERASE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 ILE A  67
ARG A 145
GLN A  52
PRO A  55
ILE A  63
 None
 1.04A 4m2xC-3gn3A:
undetectable		 4m2xC-3gn3A:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 3gn3 PUTATIVE
PROTEIN-DISULFIDE
ISOMERASE
(Pseudomonas
syringae
group
genomosp.
3) 		3 / 3 VAL A  62
PHE A  94
ARG A 115
 None
 0.94A 4xr4B-3gn3A:
undetectable		 4xr4B-3gn3A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 3gn3 PUTATIVE
PROTEIN-DISULFIDE
ISOMERASE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 ILE A 113
ALA A 114
ARG A 118
ALA A 107
PHE A 128
 None
 1.45A 4zo1X-3gn3A:
undetectable		 4zo1X-3gn3A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 3gn3 PUTATIVE
PROTEIN-DISULFIDE
ISOMERASE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 TYR A 143
ALA A   5
THR A  46
LEU A  14
ILE A 157
 None
 1.00A 6aybA-3gn3A:
undetectable		 6aybA-3gn3A:
17.85