SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gnl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 3gnl UNCHARACTERIZED
PROTEIN, DUF633,
LMOF2365_1472
(Listeria
monocytogenes) 		5 / 11 GLY A  83
GLY A  85
ARG A  81
ILE A  89
LEU A  86
 None
 1.00A 1jg3B-3gnlA:
7.9		 1jg3B-3gnlA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3gnl UNCHARACTERIZED
PROTEIN, DUF633,
LMOF2365_1472
(Listeria
monocytogenes) 		4 / 7 ARG A 137
ALA A 133
ILE A 108
PRO A 129
 None
 1.14A 1oniA-3gnlA:
undetectable
1oniB-3gnlA:
undetectable		 1oniA-3gnlA:
20.08
1oniB-3gnlA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3gnl UNCHARACTERIZED
PROTEIN, DUF633,
LMOF2365_1472
(Listeria
monocytogenes) 		4 / 6 ARG A 137
ALA A 133
ILE A 108
PRO A 129
 None
 1.14A 1oniB-3gnlA:
undetectable
1oniC-3gnlA:
undetectable		 1oniB-3gnlA:
20.08
1oniC-3gnlA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3gnl UNCHARACTERIZED
PROTEIN, DUF633,
LMOF2365_1472
(Listeria
monocytogenes) 		4 / 7 ILE A  78
PHE A  51
ALA A  49
ILE A  95
 None
 0.98A 1oniB-3gnlA:
undetectable
1oniC-3gnlA:
undetectable		 1oniB-3gnlA:
20.08
1oniC-3gnlA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3gnl UNCHARACTERIZED
PROTEIN, DUF633,
LMOF2365_1472
(Listeria
monocytogenes) 		4 / 7 ILE A 108
PRO A 129
ARG A 137
ALA A 133
 None
 1.12A 1oniG-3gnlA:
undetectable
1oniI-3gnlA:
undetectable		 1oniG-3gnlA:
20.08
1oniI-3gnlA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 3gnl UNCHARACTERIZED
PROTEIN, DUF633,
LMOF2365_1472
(Listeria
monocytogenes) 		3 / 3 LEU A  39
LEU A  16
SER A  13
 None
 0.55A 1tlmA-3gnlA:
undetectable		 1tlmA-3gnlA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 3gnl UNCHARACTERIZED
PROTEIN, DUF633,
LMOF2365_1472
(Listeria
monocytogenes) 		5 / 12 PRO A  40
ALA A 120
LEU A 119
ALA A 117
ILE A  32
 None
 1.11A 2jjpA-3gnlA:
undetectable		 2jjpA-3gnlA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 3gnl UNCHARACTERIZED
PROTEIN, DUF633,
LMOF2365_1472
(Listeria
monocytogenes) 		5 / 12 LEU A 165
ILE A  98
ILE A  89
GLY A 115
LEU A 127
 None
 1.00A 2o4nA-3gnlA:
undetectable		 2o4nA-3gnlA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 3gnl UNCHARACTERIZED
PROTEIN, DUF633,
LMOF2365_1472
(Listeria
monocytogenes) 		5 / 12 ILE A  29
ALA A  20
LEU A  12
GLN A  47
LEU A  74
 None
 0.98A 3ix9B-3gnlA:
2.9		 3ix9B-3gnlA:
23.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3gnl UNCHARACTERIZED
PROTEIN, DUF633,
LMOF2365_1472
(Listeria
monocytogenes) 		12 / 12 ARG A  15
LEU A  16
GLY A  33
VAL A  57
PRO A  61
ASN A  84
GLY A  85
ALA A 101
GLY A 102
MET A 103
LEU A 107
ILE A 111
 None
 0.39A 3ku1A-3gnlA:
31.9		 3ku1A-3gnlA:
42.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3gnl UNCHARACTERIZED
PROTEIN, DUF633,
LMOF2365_1472
(Listeria
monocytogenes) 		6 / 12 LEU A  39
PRO A  61
ALA A 101
MET A 103
LEU A 107
ILE A 111
 None
 1.49A 3ku1A-3gnlA:
31.9		 3ku1A-3gnlA:
42.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3gnl UNCHARACTERIZED
PROTEIN, DUF633,
LMOF2365_1472
(Listeria
monocytogenes) 		11 / 12 ARG A  15
LEU A  16
GLY A  33
VAL A  57
PRO A  61
GLY A  85
ALA A 101
GLY A 102
MET A 103
LEU A 107
ILE A 111
 None
 0.29A 3ku1C-3gnlA:
31.7		 3ku1C-3gnlA:
42.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3gnl UNCHARACTERIZED
PROTEIN, DUF633,
LMOF2365_1472
(Listeria
monocytogenes) 		6 / 12 GLY A  33
ASP A  35
GLY A  85
MET A 103
LEU A 107
ILE A 111
 None
 1.14A 3ku1C-3gnlA:
31.7		 3ku1C-3gnlA:
42.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3gnl UNCHARACTERIZED
PROTEIN, DUF633,
LMOF2365_1472
(Listeria
monocytogenes) 		7 / 12 LEU A  39
GLY A  33
PRO A  61
ALA A 101
MET A 103
LEU A 107
ILE A 111
 None
 1.43A 3ku1C-3gnlA:
31.7		 3ku1C-3gnlA:
42.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3gnl UNCHARACTERIZED
PROTEIN, DUF633,
LMOF2365_1472
(Listeria
monocytogenes) 		11 / 12 ARG A  15
LEU A  16
GLY A  33
VAL A  57
PRO A  61
ASN A  84
GLY A  85
ALA A 101
GLY A 102
LEU A 107
ILE A 111
 None
 0.42A 3ku1G-3gnlA:
31.8		 3ku1G-3gnlA:
42.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3gnl UNCHARACTERIZED
PROTEIN, DUF633,
LMOF2365_1472
(Listeria
monocytogenes) 		8 / 12 GLY A  33
ASP A  35
VAL A  57
ASN A  84
GLY A  85
GLY A 102
LEU A 107
ILE A 111
 None
 0.77A 3ku1G-3gnlA:
31.8		 3ku1G-3gnlA:
42.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3gnl UNCHARACTERIZED
PROTEIN, DUF633,
LMOF2365_1472
(Listeria
monocytogenes) 		5 / 12 GLY A  55
VAL A  57
ASN A  84
GLY A  85
ILE A 111
 None
 1.03A 3ku1G-3gnlA:
31.8		 3ku1G-3gnlA:
42.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3gnl UNCHARACTERIZED
PROTEIN, DUF633,
LMOF2365_1472
(Listeria
monocytogenes) 		11 / 12 ARG A  15
LEU A  16
GLY A  33
VAL A  57
VAL A  58
PRO A  61
GLY A  85
ALA A 101
MET A 103
LEU A 107
ILE A 111
 None
 0.43A 3ku1H-3gnlA:
31.6		 3ku1H-3gnlA:
42.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3gnl UNCHARACTERIZED
PROTEIN, DUF633,
LMOF2365_1472
(Listeria
monocytogenes) 		6 / 12 GLY A  33
ASP A  35
GLY A  85
MET A 103
LEU A 107
ILE A 111
 None
 0.82A 3ku1H-3gnlA:
31.6		 3ku1H-3gnlA:
42.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3gnl UNCHARACTERIZED
PROTEIN, DUF633,
LMOF2365_1472
(Listeria
monocytogenes) 		7 / 12 LEU A  39
GLY A  33
PRO A  61
ALA A 101
MET A 103
LEU A 107
ILE A 111
 None
 1.41A 3ku1H-3gnlA:
31.6		 3ku1H-3gnlA:
42.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 3gnl UNCHARACTERIZED
PROTEIN, DUF633,
LMOF2365_1472
(Listeria
monocytogenes) 		5 / 12 TRP A 139
LEU A 125
LEU A 107
GLY A 105
ILE A 111
 None
 1.05A 3uwlB-3gnlA:
undetectable		 3uwlB-3gnlA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 3gnl UNCHARACTERIZED
PROTEIN, DUF633,
LMOF2365_1472
(Listeria
monocytogenes) 		5 / 12 TRP A 139
LEU A 125
LEU A 107
GLY A 105
ILE A 111
 None
 1.09A 3uwlD-3gnlA:
undetectable		 3uwlD-3gnlA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 3gnl UNCHARACTERIZED
PROTEIN, DUF633,
LMOF2365_1472
(Listeria
monocytogenes) 		4 / 5 VAL A  19
ILE A  23
VAL A  99
THR A  97
 None
 0.54A 4xdtA-3gnlA:
undetectable		 4xdtA-3gnlA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 3gnl UNCHARACTERIZED
PROTEIN, DUF633,
LMOF2365_1472
(Listeria
monocytogenes) 		5 / 11 GLY A  33
ILE A  53
ASP A  79
VAL A  80
PRO A  40
 None
 1.23A 5hjiA-3gnlA:
11.9		 5hjiA-3gnlA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 3gnl UNCHARACTERIZED
PROTEIN, DUF633,
LMOF2365_1472
(Listeria
monocytogenes) 		4 / 8 ILE A  95
ILE A 126
ALA A  43
THR A  48
 None
 0.77A 5og9A-3gnlA:
4.5		 5og9A-3gnlA:
21.22