SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gnn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 3gnn NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Burkholderia
pseudomallei) 		4 / 7 LEU A 152
GLY A 154
LEU A 157
LYS A 160
 None
 0.94A 1gtiD-3gnnA:
undetectable		 1gtiD-3gnnA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 3gnn NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Burkholderia
pseudomallei) 		4 / 7 LEU A 152
GLY A 154
LEU A 157
LYS A 160
 None
 0.94A 1gtiE-3gnnA:
undetectable		 1gtiE-3gnnA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 3gnn NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Burkholderia
pseudomallei) 		3 / 3 PHE A  71
VAL A  84
TRP A  86
 None
 0.72A 2cc8A-3gnnA:
undetectable		 2cc8A-3gnnA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 3gnn NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Burkholderia
pseudomallei) 		3 / 3 PHE A  71
VAL A  84
TRP A  86
 None
 0.73A 2ccbA-3gnnA:
undetectable		 2ccbA-3gnnA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 3gnn NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Burkholderia
pseudomallei) 		4 / 6 LEU A 124
GLU A  90
ALA A 128
THR A 131
 None
 1.08A 2roxB-3gnnA:
undetectable		 2roxB-3gnnA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 3gnn NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Burkholderia
pseudomallei) 		5 / 12 PHE A  10
ALA A  77
LEU A  33
ALA A  32
GLY A  67
 None
 1.01A 2ve3A-3gnnA:
undetectable		 2ve3A-3gnnA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 3gnn NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Burkholderia
pseudomallei) 		3 / 3 PHE A  71
VAL A  84
TRP A  86
 None
 0.73A 2vx9A-3gnnA:
undetectable		 2vx9A-3gnnA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A600_1
(ORF12)		 3gnn NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Burkholderia
pseudomallei) 		5 / 11 SER A 255
THR A 148
SER A 275
TYR A 134
GLY A 256
 None
 0.97A 2xf3A-3gnnA:
undetectable		 2xf3A-3gnnA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_B_J01B600_1
(ORF12)		 3gnn NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Burkholderia
pseudomallei) 		5 / 11 SER A 255
THR A 148
SER A 275
TYR A 134
GLY A 256
 None
 0.95A 2xf3B-3gnnA:
undetectable		 2xf3B-3gnnA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		 3gnn NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Burkholderia
pseudomallei) 		4 / 5 PHE A  21
ALA A  20
GLY A  18
TYR A  17
 None
 1.21A 3bcrA-3gnnA:
undetectable		 3bcrA-3gnnA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 3gnn NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Burkholderia
pseudomallei) 		4 / 8 ALA A  24
ILE A  25
ASN A  28
PRO A  69
 None
 0.92A 3fxrA-3gnnA:
undetectable		 3fxrA-3gnnA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 3gnn NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Burkholderia
pseudomallei) 		4 / 7 LEU A 118
LEU A 121
SER A 125
THR A 286
 None
 1.03A 3ozkB-3gnnA:
undetectable		 3ozkB-3gnnA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 3gnn NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Burkholderia
pseudomallei) 		4 / 7 VAL A  59
SER A 125
TYR A 288
MET A  94
 None
 1.24A 4hxyB-3gnnA:
undetectable		 4hxyB-3gnnA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 3gnn NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Burkholderia
pseudomallei) 		4 / 6 LEU A 118
LEU A 121
SER A 125
THR A 286
 None
 1.04A 4ikiB-3gnnA:
undetectable		 4ikiB-3gnnA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 3gnn NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Burkholderia
pseudomallei) 		4 / 7 LEU A 118
LEU A 121
SER A 125
THR A 286
 None
 1.03A 4ikjA-3gnnA:
undetectable
4ikjB-3gnnA:
undetectable		 4ikjA-3gnnA:
18.15
4ikjB-3gnnA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 3gnn NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Burkholderia
pseudomallei) 		5 / 12 TYR A 288
GLY A  67
LEU A 123
ALA A 158
CYH A  66
 None
 1.15A 4krhB-3gnnA:
undetectable		 4krhB-3gnnA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3gnn NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Burkholderia
pseudomallei) 		5 / 7 GLU A 268
ILE A 266
ARG A 273
LEU A 230
MET A 239
 None
 1.13A 4xumA-3gnnA:
undetectable		 4xumA-3gnnA:
22.51