SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3go1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 3go1 FAB 268-D, LIGHT
CHAIN
(Homo
sapiens) 		4 / 8 VAL L 106
ARG L  61
ALA L  19
GLU L  83
 None
SO4  L 210 (-4.0A)
None
None
 0.92A 1dmiA-3go1L:
undetectable
1dmiB-3go1L:
undetectable		 1dmiA-3go1L:
18.59
1dmiB-3go1L:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 3go1 FAB 268-D, HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 ARG H  66
SER H  62
LEU H  80
LEU H  18
ASP H  86
 None
 1.43A 1e7wA-3go1H:
undetectable		 1e7wA-3go1H:
23.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JNN_H_ESTH350_1
(MONOCLONAL
ANTI-ESTRADIOL
17E12E5
IMMUNOGLOBULIN
GAMMA-1 CHAIN
MONOCLONAL
ANTI-ESTRADIOL
17E12E5
IMMUNOGLOBULIN KAPPA
CHAIN)		 3go1 FAB 268-D, HEAVY
CHAIN
FAB 268-D, LIGHT
CHAIN
(Homo
sapiens) 		5 / 10 GLU H  95
TYR L  36
LEU L  46
TYR L  49
TYR L  96
 None
 0.80A 1jnnH-3go1H:
22.8
1jnnL-3go1H:
14.2		 1jnnH-3go1H:
51.57
1jnnL-3go1H:
28.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 3go1 FAB 268-D, HEAVY
CHAIN
(Homo
sapiens) 		4 / 7 THR H  54
TYR H  52
ASN H  58
TYR H  33
 None
None
SO4  H 214 (-4.4A)
None
 1.12A 1qzrB-3go1H:
undetectable		 1qzrB-3go1H:
20.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 3go1 FAB 268-D, HEAVY
CHAIN
FAB 268-D, LIGHT
CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TYR L  36
PRO L  44
TYR L  87
TYR H  91
 None
 0.74A 2oldA-3go1L:
19.7
2oldB-3go1L:
23.8		 2oldA-3go1L:
75.12
2oldB-3go1L:
75.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 3go1 FAB 268-D, LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 LEU L 132
ALA L 130
LEU L 178
THR L 181
 None
 1.01A 3cfqA-3go1L:
3.9
3cfqB-3go1L:
undetectable		 3cfqA-3go1L:
23.08
3cfqB-3go1L:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 3go1 FAB 268-D, LIGHT
CHAIN
(Homo
sapiens) 		3 / 3 THR L 114
SER L 137
PHE L 118
 None
 0.81A 3d4sA-3go1L:
undetectable		 3d4sA-3go1L:
16.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GKZ_A_B40A500_1
(ANTI-METHAMPHETAMINE
SINGLE CHAIN FV)		 3go1 FAB 268-D, HEAVY
CHAIN
FAB 268-D, LIGHT
CHAIN
(Homo
sapiens) 		5 / 11 TYR H  33
TYR H  47
TYR H  50
TYR L  34
TYR L  36
 None
 0.83A 3gkzA-3go1H:
21.1		 3gkzA-3go1H:
39.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GM0_A_B41A600_1
(ANTI-METHAMPHETAMINE
SINGLE CHAIN FV)		 3go1 FAB 268-D, HEAVY
CHAIN
FAB 268-D, LIGHT
CHAIN
(Homo
sapiens) 		5 / 11 TYR H  33
TYR H  47
TYR H  50
TYR L  34
TYR L  36
 None
 0.87A 3gm0A-3go1H:
20.4		 3gm0A-3go1H:
39.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3go1 FAB 268-D, LIGHT
CHAIN
(Homo
sapiens) 		4 / 8 THR L  74
TYR L  86
TRP L  35
ARG L  20
 None
 1.32A 3wipB-3go1L:
3.1
3wipC-3go1L:
3.0		 3wipB-3go1L:
23.89
3wipC-3go1L:
23.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GQP_H_B40H1201_1
(ANTI-METH SCFV)		 3go1 FAB 268-D, HEAVY
CHAIN
FAB 268-D, LIGHT
CHAIN
(Homo
sapiens) 		5 / 11 TYR H  33
TYR H  47
TYR H  50
TYR L  34
TYR L  36
 None
 0.83A 4gqpH-3go1H:
21.1		 4gqpH-3go1H:
39.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 3go1 FAB 268-D, LIGHT
CHAIN
(Homo
sapiens) 		3 / 3 ALA L  27
GLN L   6
GLY L 101
 SO4  L 209 (-3.4A)
None
None
 0.58A 4odoC-3go1L:
undetectable		 4odoC-3go1L:
21.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		 3go1 FAB 268-D, LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 TYR L  32
TYR L  36
TYR L  49
PRO L  55
 None
 0.53A 5aclA-3go1L:
20.4		 5aclA-3go1L:
56.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 3go1 FAB 268-D, LIGHT
CHAIN
(Homo
sapiens) 		4 / 6 LEU L 132
ALA L 130
LEU L 178
THR L 181
 None
 1.04A 5bojA-3go1L:
4.0		 5bojA-3go1L:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3go1 FAB 268-D, LIGHT
CHAIN
(Homo
sapiens) 		4 / 5 ALA L 173
TYR L 172
PRO L  40
GLY L  99
 None
 0.90A 5eslA-3go1L:
undetectable		 5eslA-3go1L:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 3go1 FAB 268-D, LIGHT
CHAIN
(Homo
sapiens) 		4 / 6 LEU L 132
ALA L 130
LEU L 178
THR L 181
 None
 1.01A 5l4iA-3go1L:
undetectable		 5l4iA-3go1L:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 3go1 FAB 268-D, LIGHT
CHAIN
(Homo
sapiens) 		4 / 6 GLN L  89
LEU L  46
ARG L  37
PRO L  44
 None
 1.26A 6brdB-3go1L:
undetectable		 6brdB-3go1L:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 3go1 FAB 268-D, HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 VAL H 207
THR H 205
VAL H 211
GLY H 118
VAL H 152
 None
 1.00A 6drzA-3go1H:
undetectable		 6drzA-3go1H:
18.60