SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3go4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1867_0
(FPRA)		 3go4 PROTEIN OF UNKNOWN
FUNCTION DUF574
(Streptomyces
avermitilis) 		4 / 4 ALA A  98
ARG A  79
GLN A  99
GLU A 104
 None
 1.28A 1lqtB-3go4A:
1.1		 1lqtB-3go4A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1424_0
(FPRA)		 3go4 PROTEIN OF UNKNOWN
FUNCTION DUF574
(Streptomyces
avermitilis) 		4 / 4 ALA A  98
ARG A  79
GLN A  99
GLU A 104
 None
 1.26A 1lquB-3go4A:
undetectable		 1lquB-3go4A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3go4 PROTEIN OF UNKNOWN
FUNCTION DUF574
(Streptomyces
avermitilis) 		4 / 7 TYR A  27
GLY A  87
ASP A 111
ASP A 138
 SAH  A 277 (-4.3A)
SAH  A 277 (-3.1A)
SAH  A 277 (-2.7A)
SAH  A 277 (-3.5A)
 0.67A 2g72B-3go4A:
12.9		 2g72B-3go4A:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 3go4 PROTEIN OF UNKNOWN
FUNCTION DUF574
(Streptomyces
avermitilis) 		5 / 9 LEU A 185
VAL A 182
VAL A 172
ILE A 168
VAL A 169
 None
None
None
SAH  A 277 (-4.0A)
None
 1.35A 2l8mA-3go4A:
undetectable		 2l8mA-3go4A:
23.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3go4 PROTEIN OF UNKNOWN
FUNCTION DUF574
(Streptomyces
avermitilis) 		5 / 12 ALA A  24
TYR A  27
GLY A  85
GLY A  87
ASP A 138
 SAH  A 277 (-3.1A)
SAH  A 277 (-4.3A)
SAH  A 277 (-3.4A)
SAH  A 277 (-3.1A)
SAH  A 277 (-3.5A)
 0.44A 2qe6A-3go4A:
36.4		 2qe6A-3go4A:
40.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3go4 PROTEIN OF UNKNOWN
FUNCTION DUF574
(Streptomyces
avermitilis) 		3 / 3 ASN A  61
ARG A  62
ASP A 111
 SAH  A 277 (-3.5A)
SAH  A 277 (-4.0A)
SAH  A 277 (-2.7A)
 0.61A 2qe6A-3go4A:
36.4		 2qe6A-3go4A:
40.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3go4 PROTEIN OF UNKNOWN
FUNCTION DUF574
(Streptomyces
avermitilis) 		5 / 12 ALA A  24
TYR A  27
GLY A  85
GLY A  87
ASP A 138
 SAH  A 277 (-3.1A)
SAH  A 277 (-4.3A)
SAH  A 277 (-3.4A)
SAH  A 277 (-3.1A)
SAH  A 277 (-3.5A)
 0.48A 2qe6B-3go4A:
36.1		 2qe6B-3go4A:
40.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3go4 PROTEIN OF UNKNOWN
FUNCTION DUF574
(Streptomyces
avermitilis) 		3 / 3 ASN A  61
ARG A  62
ASP A 111
 SAH  A 277 (-3.5A)
SAH  A 277 (-4.0A)
SAH  A 277 (-2.7A)
 0.60A 2qe6B-3go4A:
36.1		 2qe6B-3go4A:
40.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3go4 PROTEIN OF UNKNOWN
FUNCTION DUF574
(Streptomyces
avermitilis) 		4 / 7 ILE A  84
LEU A 185
THR A 154
LEU A 151
 None
 0.96A 3ag3A-3go4A:
undetectable
3ag3J-3go4A:
undetectable		 3ag3A-3go4A:
21.04
3ag3J-3go4A:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 3go4 PROTEIN OF UNKNOWN
FUNCTION DUF574
(Streptomyces
avermitilis) 		5 / 12 ILE A  84
GLY A  85
ASP A 111
ILE A 166
ALA A 167
 None
SAH  A 277 (-3.4A)
SAH  A 277 (-2.7A)
SAH  A 277 (-3.8A)
SAH  A 277 (-3.4A)
 0.55A 3jb1A-3go4A:
10.8		 3jb1A-3go4A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3go4 PROTEIN OF UNKNOWN
FUNCTION DUF574
(Streptomyces
avermitilis) 		3 / 3 TYR A  27
ASP A 111
ASP A 138
 SAH  A 277 (-4.3A)
SAH  A 277 (-2.7A)
SAH  A 277 (-3.5A)
 0.78A 3ou6B-3go4A:
12.7		 3ou6B-3go4A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3go4 PROTEIN OF UNKNOWN
FUNCTION DUF574
(Streptomyces
avermitilis) 		3 / 3 GLY A  87
ASP A 111
ASP A 138
 SAH  A 277 (-3.1A)
SAH  A 277 (-2.7A)
SAH  A 277 (-3.5A)
 0.24A 3ou7C-3go4A:
12.6		 3ou7C-3go4A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB665_1
(ALPHA-GLUCOSIDASE)		 3go4 PROTEIN OF UNKNOWN
FUNCTION DUF574
(Streptomyces
avermitilis) 		4 / 6 LYS A  41
ASP A  40
TYR A  36
ASP A  28
 None
None
None
SO4  A 278 ( 4.2A)
 1.32A 3pocB-3go4A:
undetectable		 3pocB-3go4A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3go4 PROTEIN OF UNKNOWN
FUNCTION DUF574
(Streptomyces
avermitilis) 		5 / 12 TYR A  29
ILE A 166
GLY A  87
ALA A  24
SER A 198
 None
SAH  A 277 (-3.8A)
SAH  A 277 (-3.1A)
SAH  A 277 (-3.1A)
None
 1.13A 3sudB-3go4A:
undetectable		 3sudB-3go4A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3go4 PROTEIN OF UNKNOWN
FUNCTION DUF574
(Streptomyces
avermitilis) 		5 / 12 ASP A  83
GLY A  85
ASP A 111
ASP A 138
ILE A 168
 SAH  A 277 ( 4.7A)
SAH  A 277 (-3.4A)
SAH  A 277 (-2.7A)
SAH  A 277 (-3.5A)
SAH  A 277 (-4.0A)
 0.96A 4pghB-3go4A:
12.7		 4pghB-3go4A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3go4 PROTEIN OF UNKNOWN
FUNCTION DUF574
(Streptomyces
avermitilis) 		5 / 12 ASP A  83
GLY A  85
ASP A 138
MET A 139
ILE A 168
 SAH  A 277 ( 4.7A)
SAH  A 277 (-3.4A)
SAH  A 277 (-3.5A)
None
SAH  A 277 (-4.0A)
 1.20A 4pghB-3go4A:
12.7		 4pghB-3go4A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3go4 PROTEIN OF UNKNOWN
FUNCTION DUF574
(Streptomyces
avermitilis) 		5 / 12 TYR A  27
GLY A  85
GLY A  87
MET A 139
ILE A 166
 SAH  A 277 (-4.3A)
SAH  A 277 (-3.4A)
SAH  A 277 (-3.1A)
None
SAH  A 277 (-3.8A)
 1.02A 4qtuD-3go4A:
12.2		 4qtuD-3go4A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 3go4 PROTEIN OF UNKNOWN
FUNCTION DUF574
(Streptomyces
avermitilis) 		4 / 7 ILE A  84
TYR A 134
ALA A 137
ILE A 145
 None
 0.83A 4y03A-3go4A:
undetectable		 4y03A-3go4A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 3go4 PROTEIN OF UNKNOWN
FUNCTION DUF574
(Streptomyces
avermitilis) 		4 / 4 ASP A  83
GLY A  87
ASP A 111
ASP A 138
 SAH  A 277 ( 4.7A)
SAH  A 277 (-3.1A)
SAH  A 277 (-2.7A)
SAH  A 277 (-3.5A)
 0.63A 5e72A-3go4A:
10.7		 5e72A-3go4A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 3go4 PROTEIN OF UNKNOWN
FUNCTION DUF574
(Streptomyces
avermitilis) 		4 / 4 LEU A 163
ILE A  84
PRO A 142
LEU A 146
 None
 1.12A 5eb3A-3go4A:
3.2		 5eb3A-3go4A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 3go4 PROTEIN OF UNKNOWN
FUNCTION DUF574
(Streptomyces
avermitilis) 		4 / 7 ARG A 152
ALA A 148
LEU A 155
LEU A 157
 None
 0.67A 5jq7A-3go4A:
undetectable		 5jq7A-3go4A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 3go4 PROTEIN OF UNKNOWN
FUNCTION DUF574
(Streptomyces
avermitilis) 		5 / 12 GLY A  85
GLY A  87
ASN A 112
ASP A 138
ALA A 167
 SAH  A 277 (-3.4A)
SAH  A 277 (-3.1A)
SAH  A 277 (-3.3A)
SAH  A 277 (-3.5A)
SAH  A 277 (-3.4A)
 0.47A 5kpcB-3go4A:
9.7		 5kpcB-3go4A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 3go4 PROTEIN OF UNKNOWN
FUNCTION DUF574
(Streptomyces
avermitilis) 		4 / 7 GLY A  33
TYR A 216
ASP A  40
TYR A  37
 SO4  A 278 (-3.1A)
None
None
None
 1.14A 5vlmG-3go4A:
undetectable		 5vlmG-3go4A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_A_GM4A301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3go4 PROTEIN OF UNKNOWN
FUNCTION DUF574
(Streptomyces
avermitilis) 		5 / 11 VAL A  69
ALA A  73
MET A  65
ASP A 254
ALA A  98
 None
 1.34A 6dk1A-3go4A:
0.0		 6dk1A-3go4A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 3go4 PROTEIN OF UNKNOWN
FUNCTION DUF574
(Streptomyces
avermitilis) 		5 / 11 GLY A  85
GLY A  87
ASP A 111
VAL A 116
ASP A 138
 SAH  A 277 (-3.4A)
SAH  A 277 (-3.1A)
SAH  A 277 (-2.7A)
None
SAH  A 277 (-3.5A)
 1.07A 6i5zD-3go4A:
11.7		 6i5zD-3go4A:
22.28