SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3go9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 3go9 INSULINASE FAMILY
PROTEASE
(Yersinia
pestis) 		5 / 11 HIS A 309
PHE A 372
LEU A 301
GLU A 304
ALA A 305
 ZN  A 603 (-3.2A)
None
None
None
None
 1.31A 1mjlA-3go9A:
undetectable
1mjlB-3go9A:
undetectable		 1mjlA-3go9A:
10.88
1mjlB-3go9A:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 3go9 INSULINASE FAMILY
PROTEASE
(Yersinia
pestis) 		3 / 3 GLU A  58
GLN A 401
ARG A 404
 None
 0.91A 2w3bB-3go9A:
undetectable		 2w3bB-3go9A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3go9 INSULINASE FAMILY
PROTEASE
(Yersinia
pestis) 		4 / 8 ASP A 412
ASP A  30
ASP A 396
TYR A 390
 None
None
ZN  A 601 (-3.4A)
None
 1.05A 3havA-3go9A:
undetectable		 3havA-3go9A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB0_A_DIFA701_1
(LACTOTRANSFERRIN)		 3go9 INSULINASE FAMILY
PROTEASE
(Yersinia
pestis) 		4 / 4 PRO A 193
TYR A 118
GLY A  66
THR A  65
 None
 1.41A 3ib0A-3go9A:
undetectable		 3ib0A-3go9A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_D_ACTD1113_0
(BLR5658 PROTEIN)		 3go9 INSULINASE FAMILY
PROTEASE
(Yersinia
pestis) 		4 / 4 TRP A 101
LEU A 125
LEU A 142
THR A 145
 None
 1.46A 4bboD-3go9A:
undetectable		 4bboD-3go9A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 3go9 INSULINASE FAMILY
PROTEASE
(Yersinia
pestis) 		5 / 10 LEU A 464
LEU A 348
ASN A 351
VAL A 355
LEU A 324
 None
 0.88A 4po0A-3go9A:
undetectable		 4po0A-3go9A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		 3go9 INSULINASE FAMILY
PROTEASE
(Yersinia
pestis) 		5 / 10 ASP A 300
LEU A 301
LEU A 383
LYS A 379
LEU A 386
 PEG  A 607 (-3.3A)
None
None
None
None
 1.13A 4zbrA-3go9A:
undetectable		 4zbrA-3go9A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MTH_A_ACTA301_0
(ANTIBODY FAB HEAVY
CHAIN)		 3go9 INSULINASE FAMILY
PROTEASE
(Yersinia
pestis) 		4 / 4 THR A  65
VAL A  63
PRO A  82
THR A 121
 None
 1.26A 5mthA-3go9A:
0.4
5mthH-3go9A:
0.2		 5mthA-3go9A:
17.96
5mthH-3go9A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3go9 INSULINASE FAMILY
PROTEASE
(Yersinia
pestis) 		5 / 12 GLN A 331
GLN A 407
PRO A 112
ILE A 115
ARG A  60
 None
 1.11A 5uhbC-3go9A:
0.0		 5uhbC-3go9A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3go9 INSULINASE FAMILY
PROTEASE
(Yersinia
pestis) 		5 / 12 GLN A 331
GLN A 407
PRO A 112
ILE A 115
ARG A  60
 None
 1.10A 5uhcC-3go9A:
0.0		 5uhcC-3go9A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHD_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3go9 INSULINASE FAMILY
PROTEASE
(Yersinia
pestis) 		5 / 12 GLN A 331
GLN A 407
PRO A 112
ILE A 115
ARG A  60
 None
 1.07A 5uhdC-3go9A:
0.0		 5uhdC-3go9A:
17.92