SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3goc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 3goc ENDONUCLEASE V
(Streptomyces
avermitilis) 		5 / 12 HIS A 195
GLY A 171
TYR A 116
VAL A 141
ALA A 142
 None
 1.08A 1axwA-3gocA:
undetectable		 1axwA-3gocA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 3goc ENDONUCLEASE V
(Streptomyces
avermitilis) 		5 / 12 HIS A 195
GLY A 171
TYR A 116
VAL A 141
ALA A 142
 None
 1.09A 1tlsB-3gocA:
undetectable		 1tlsB-3gocA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 3goc ENDONUCLEASE V
(Streptomyces
avermitilis) 		5 / 12 HIS A 195
GLY A 171
TYR A 116
VAL A 141
ALA A 142
 None
 1.10A 1tsnA-3gocA:
undetectable		 1tsnA-3gocA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 3goc ENDONUCLEASE V
(Streptomyces
avermitilis) 		3 / 3 ASP A 217
GLU A  93
TYR A 116
 MG  A 301 (-3.2A)
None
None
 0.83A 1wsvA-3gocA:
undetectable		 1wsvA-3gocA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3goc ENDONUCLEASE V
(Streptomyces
avermitilis) 		5 / 12 ALA A  74
ALA A  59
LEU A 104
ALA A 103
CYH A 113
 None
 1.04A 1xdkE-3gocA:
undetectable		 1xdkE-3gocA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_3
(POL POLYPROTEIN)		 3goc ENDONUCLEASE V
(Streptomyces
avermitilis) 		5 / 12 GLY A 117
VAL A  45
ILE A 111
GLY A 131
VAL A 132
 None
 0.93A 2avsB-3gocA:
undetectable		 2avsB-3gocA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 3goc ENDONUCLEASE V
(Streptomyces
avermitilis) 		5 / 12 TYR A  84
GLY A  87
PHE A 124
VAL A  20
ARG A  92
 None
CL  A 303 (-3.4A)
None
None
None
 1.21A 3dlcA-3gocA:
undetectable		 3dlcA-3gocA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 3goc ENDONUCLEASE V
(Streptomyces
avermitilis) 		5 / 10 VAL A 191
ILE A 139
ALA A 202
THR A 204
VAL A 185
 None
 1.09A 3me6A-3gocA:
undetectable		 3me6A-3gocA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 3goc ENDONUCLEASE V
(Streptomyces
avermitilis) 		5 / 9 VAL A 191
ILE A 139
ALA A 202
THR A 204
VAL A 185
 None
 1.03A 3me6D-3gocA:
undetectable		 3me6D-3gocA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_2
(PROTEASE)		 3goc ENDONUCLEASE V
(Streptomyces
avermitilis) 		5 / 12 GLY A 117
VAL A  45
ILE A 111
GLY A 131
VAL A 132
 None
 1.08A 3nu5B-3gocA:
undetectable		 3nu5B-3gocA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_1
(HIV-1 PROTEASE)		 3goc ENDONUCLEASE V
(Streptomyces
avermitilis) 		5 / 12 GLY A 117
VAL A  45
ILE A 111
GLY A 131
VAL A 132
 None
 1.07A 3oxxA-3gocA:
undetectable		 3oxxA-3gocA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3goc ENDONUCLEASE V
(Streptomyces
avermitilis) 		5 / 12 GLY A  44
THR A 138
ALA A  58
VAL A  97
VAL A  61
 None
 1.31A 4df3A-3gocA:
undetectable		 4df3A-3gocA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3goc ENDONUCLEASE V
(Streptomyces
avermitilis) 		5 / 12 GLY A  44
THR A 138
ALA A  58
VAL A  97
VAL A  61
 None
 1.32A 4df3B-3gocA:
undetectable		 4df3B-3gocA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 3goc ENDONUCLEASE V
(Streptomyces
avermitilis) 		4 / 8 GLY A  38
ALA A  65
ASP A  64
PRO A 137
 None
 0.88A 4eyrB-3gocA:
undetectable		 4eyrB-3gocA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 3goc ENDONUCLEASE V
(Streptomyces
avermitilis) 		5 / 12 HIS A 195
GLY A 171
TYR A 116
VAL A 141
ALA A 142
 None
 1.09A 4fqsA-3gocA:
undetectable		 4fqsA-3gocA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 3goc ENDONUCLEASE V
(Streptomyces
avermitilis) 		5 / 12 HIS A 195
GLY A 171
TYR A 116
VAL A 141
ALA A 142
 None
 1.10A 4fqsB-3gocA:
undetectable		 4fqsB-3gocA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3goc ENDONUCLEASE V
(Streptomyces
avermitilis) 		5 / 10 ALA A  76
THR A  75
ALA A  74
VAL A   4
ASP A 102
 None
 0.80A 4qvyK-3gocA:
undetectable
4qvyL-3gocA:
undetectable		 4qvyK-3gocA:
22.96
4qvyL-3gocA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3goc ENDONUCLEASE V
(Streptomyces
avermitilis) 		5 / 10 ALA A  76
THR A  75
ALA A  74
VAL A   4
ASP A 102
 None
 0.80A 4qvyY-3gocA:
undetectable
4qvyZ-3gocA:
undetectable		 4qvyY-3gocA:
22.96
4qvyZ-3gocA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 3goc ENDONUCLEASE V
(Streptomyces
avermitilis) 		5 / 9 ALA A  90
GLY A 117
ALA A 127
THR A 138
VAL A 132
 None
 1.17A 4r1zA-3gocA:
undetectable		 4r1zA-3gocA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3goc ENDONUCLEASE V
(Streptomyces
avermitilis) 		4 / 5 THR A 213
GLY A  44
GLU A  93
ASP A 114
 None
None
None
MG  A 302 (-3.9A)
 1.09A 5c0oH-3gocA:
undetectable		 5c0oH-3gocA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3goc ENDONUCLEASE V
(Streptomyces
avermitilis) 		4 / 7 PHE A 124
GLY A 131
THR A 134
LEU A  98
 None
 1.02A 5esmA-3gocA:
undetectable		 5esmA-3gocA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3goc ENDONUCLEASE V
(Streptomyces
avermitilis) 		3 / 3 VAL A 185
HIS A 195
VAL A 191
 None
 0.62A 5jmnC-3gocA:
undetectable		 5jmnC-3gocA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 3goc ENDONUCLEASE V
(Streptomyces
avermitilis) 		6 / 12 ILE A 111
LEU A  63
VAL A  61
LEU A 130
THR A 212
LEU A  98
 None
 1.39A 6b54A-3gocA:
undetectable		 6b54A-3gocA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 3goc ENDONUCLEASE V
(Streptomyces
avermitilis) 		3 / 3 THR A  75
ALA A 223
LYS A 225
 None
 0.50A 6fgcA-3gocA:
undetectable		 6fgcA-3gocA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 3goc ENDONUCLEASE V
(Streptomyces
avermitilis) 		3 / 3 THR A  75
ALA A 223
LYS A 225
 None
 0.51A 6fgdA-3gocA:
undetectable		 6fgdA-3gocA:
23.44