SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gon'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 3gon PHOSPHOMEVALONATE
KINASE
(Streptococcus
pneumoniae) 		4 / 5 GLU A 279
THR A 271
LEU A 273
LEU A 274
 None
 0.93A 1u18B-3gonA:
undetectable		 1u18B-3gonA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3gon PHOSPHOMEVALONATE
KINASE
(Streptococcus
pneumoniae) 		4 / 6 TYR A  11
GLY A 146
ASP A 144
ASN A 145
 PMV  A 400 (-4.0A)
PMV  A 400 (-3.4A)
None
None
 1.26A 2g72A-3gonA:
undetectable		 2g72A-3gonA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 3gon PHOSPHOMEVALONATE
KINASE
(Streptococcus
pneumoniae) 		3 / 3 ASN A 145
TYR A  16
SER A 147
 None
PMV  A 400 (-3.6A)
PMV  A 400 (-2.7A)
 0.86A 2gvcB-3gonA:
undetectable		 2gvcB-3gonA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 3gon PHOSPHOMEVALONATE
KINASE
(Streptococcus
pneumoniae) 		3 / 3 ASN A 145
TYR A  16
SER A 147
 None
PMV  A 400 (-3.6A)
PMV  A 400 (-2.7A)
 0.81A 2gvcE-3gonA:
undetectable		 2gvcE-3gonA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3gon PHOSPHOMEVALONATE
KINASE
(Streptococcus
pneumoniae) 		5 / 11 LEU A 179
LEU A  72
LEU A 118
VAL A 114
VAL A 126
 None
 1.30A 2po5B-3gonA:
undetectable		 2po5B-3gonA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 3gon PHOSPHOMEVALONATE
KINASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A 179
LEU A  72
LEU A 118
VAL A 114
VAL A 126
 None
 1.33A 2qd4B-3gonA:
undetectable		 2qd4B-3gonA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 3gon PHOSPHOMEVALONATE
KINASE
(Streptococcus
pneumoniae) 		3 / 3 LYS A 133
ARG A 185
VAL A 170
 None
 0.89A 2r2vC-3gonA:
undetectable
2r2vD-3gonA:
undetectable		 2r2vC-3gonA:
7.93
2r2vD-3gonA:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 3gon PHOSPHOMEVALONATE
KINASE
(Streptococcus
pneumoniae) 		4 / 8 TYR A  11
ILE A  18
LEU A 139
PHE A 132
 PMV  A 400 (-4.0A)
PMV  A 400 (-4.6A)
None
None
 0.83A 2vctA-3gonA:
undetectable		 2vctA-3gonA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 3gon PHOSPHOMEVALONATE
KINASE
(Streptococcus
pneumoniae) 		4 / 8 TYR A  11
ILE A  18
LEU A 139
PHE A 132
 PMV  A 400 (-4.0A)
PMV  A 400 (-4.6A)
None
None
 0.86A 2vctC-3gonA:
undetectable		 2vctC-3gonA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 3gon PHOSPHOMEVALONATE
KINASE
(Streptococcus
pneumoniae) 		3 / 3 LEU A 319
ARG A 315
ILE A 321
 None
 0.60A 2xn5B-3gonA:
undetectable		 2xn5B-3gonA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 3gon PHOSPHOMEVALONATE
KINASE
(Streptococcus
pneumoniae) 		5 / 12 GLY A 205
ALA A 286
LEU A 319
THR A 309
LEU A 312
 None
 1.09A 3p2kB-3gonA:
undetectable		 3p2kB-3gonA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3gon PHOSPHOMEVALONATE
KINASE
(Streptococcus
pneumoniae) 		4 / 7 PHE A  51
MET A  50
ILE A  46
VAL A  55
 ANP  A 500 (-4.7A)
ANP  A 500 (-3.4A)
None
None
 1.08A 3p6hA-3gonA:
undetectable		 3p6hA-3gonA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_A_198A601_1
(SERUM ALBUMIN)		 3gon PHOSPHOMEVALONATE
KINASE
(Streptococcus
pneumoniae) 		5 / 10 MET A 148
ALA A 152
PHE A 132
PHE A 165
LEU A 140
 None
 1.30A 4la0A-3gonA:
2.4		 4la0A-3gonA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_B_198B601_1
(SERUM ALBUMIN)		 3gon PHOSPHOMEVALONATE
KINASE
(Streptococcus
pneumoniae) 		5 / 9 MET A 148
ALA A 152
PHE A 132
PHE A 165
LEU A 140
 None
 1.22A 4la0B-3gonA:
3.1		 4la0B-3gonA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3gon PHOSPHOMEVALONATE
KINASE
(Streptococcus
pneumoniae) 		4 / 5 LEU A  57
ASP A  75
GLU A  68
VAL A 111
 None
 1.24A 4nkvA-3gonA:
undetectable		 4nkvA-3gonA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3gon PHOSPHOMEVALONATE
KINASE
(Streptococcus
pneumoniae) 		4 / 5 TYR A  11
GLY A 146
ASP A 144
VAL A 115
 PMV  A 400 (-4.0A)
PMV  A 400 (-3.4A)
None
None
 0.80A 4nkvD-3gonA:
undetectable		 4nkvD-3gonA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3gon PHOSPHOMEVALONATE
KINASE
(Streptococcus
pneumoniae) 		4 / 5 ILE A  18
LEU A  19
ASP A 150
GLU A  15
 PMV  A 400 (-4.6A)
PMV  A 400 ( 4.8A)
None
None
 0.90A 4nkxB-3gonA:
undetectable		 4nkxB-3gonA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 3gon PHOSPHOMEVALONATE
KINASE
(Streptococcus
pneumoniae) 		5 / 10 LEU A 179
VAL A 115
LEU A 119
LEU A 131
VAL A 126
 None
 1.18A 4po0A-3gonA:
3.5		 4po0A-3gonA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3gon PHOSPHOMEVALONATE
KINASE
(Streptococcus
pneumoniae) 		5 / 11 LEU A 174
LEU A 179
GLU A  68
ALA A  71
LEU A  72
 None
 1.03A 4wg0B-3gonA:
undetectable
4wg0C-3gonA:
undetectable
4wg0D-3gonA:
undetectable		 4wg0B-3gonA:
6.90
4wg0C-3gonA:
6.90
4wg0D-3gonA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3gon PHOSPHOMEVALONATE
KINASE
(Streptococcus
pneumoniae) 		5 / 11 LEU A 174
LEU A 179
GLU A  68
ALA A  71
LEU A  72
 None
 1.02A 4wg0D-3gonA:
undetectable
4wg0E-3gonA:
undetectable
4wg0F-3gonA:
undetectable		 4wg0D-3gonA:
6.90
4wg0E-3gonA:
6.90
4wg0F-3gonA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3gon PHOSPHOMEVALONATE
KINASE
(Streptococcus
pneumoniae) 		5 / 11 LEU A 174
LEU A 179
GLU A  68
ALA A  71
LEU A  72
 None
 1.04A 4wg0F-3gonA:
undetectable
4wg0G-3gonA:
undetectable
4wg0H-3gonA:
undetectable		 4wg0F-3gonA:
6.90
4wg0G-3gonA:
6.90
4wg0H-3gonA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3gon PHOSPHOMEVALONATE
KINASE
(Streptococcus
pneumoniae) 		5 / 11 GLU A  68
ALA A  71
LEU A  72
LEU A 174
LEU A 179
 None
 1.07A 4wg0G-3gonA:
undetectable
4wg0H-3gonA:
undetectable
4wg0I-3gonA:
undetectable		 4wg0G-3gonA:
6.90
4wg0H-3gonA:
6.90
4wg0I-3gonA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3gon PHOSPHOMEVALONATE
KINASE
(Streptococcus
pneumoniae) 		5 / 12 SER A 303
VAL A 255
LEU A 319
LEU A 312
ALA A 280
 None
 1.18A 4x1kA-3gonA:
undetectable
4x1kB-3gonA:
undetectable		 4x1kA-3gonA:
20.62
4x1kB-3gonA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 3gon PHOSPHOMEVALONATE
KINASE
(Streptococcus
pneumoniae) 		3 / 3 LEU A  24
LEU A  26
TRP A  12
 None
 0.81A 5nwuA-3gonA:
undetectable		 5nwuA-3gonA:
8.60