SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gov'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 3gov MASP-1
(Homo
sapiens) 		4 / 7 LEU B 540
TYR B 544
HIS B 493
THR B 665
 None
 1.21A 1afsA-3govB:
undetectable		 1afsA-3govB:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 3gov MASP-1
(Homo
sapiens) 		4 / 7 LEU B 540
TYR B 544
HIS B 493
THR B 665
 None
 1.20A 1afsB-3govB:
undetectable		 1afsB-3govB:
19.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 3gov MASP-1
(Homo
sapiens) 		6 / 8 HIS B 490
ASP B 640
SER B 646
VAL B 666
GLY B 669
GLY B 679
 None
 0.58A 1aq7A-3govB:
35.1		 1aq7A-3govB:
35.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 3gov MASP-1
(Homo
sapiens) 		7 / 9 ASP B 640
ALA B 641
SER B 646
VAL B 666
TRP B 668
GLY B 669
GLY B 679
 None
 0.38A 1bcuH-3govB:
37.2		 1bcuH-3govB:
36.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 3gov MASP-1
(Homo
sapiens) 		5 / 9 HIS B 490
ASP B 640
SER B 646
TRP B 668
GLY B 679
 None
 0.39A 1dwcH-3govB:
36.3		 1dwcH-3govB:
36.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 3gov MASP-1
(Homo
sapiens) 		7 / 12 HIS B 490
ASP B 640
SER B 646
VAL B 666
TRP B 668
GLY B 669
GLY B 679
 None
 0.55A 1etrH-3govB:
36.0		 1etrH-3govB:
36.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3gov MASP-1
(Homo
sapiens) 		4 / 8 ASP B 640
SER B 646
VAL B 666
GLY B 679
 None
 0.51A 1f5lA-3govB:
34.0		 1f5lA-3govB:
30.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3gov MASP-1
(Homo
sapiens) 		4 / 8 SER B 646
VAL B 666
GLY B 669
GLY B 679
 None
 0.51A 1f5lA-3govB:
34.0		 1f5lA-3govB:
30.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 3gov MASP-1
(Homo
sapiens) 		5 / 6 ASP B 640
SER B 646
VAL B 666
GLY B 669
GLY B 679
 None
 0.47A 1tnlA-3govB:
35.4		 1tnlA-3govB:
35.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 3gov MASP-1
(Homo
sapiens) 		3 / 3 ASP B 507
ARG B 504
ASP B 497
 None
 0.96A 1vptA-3govB:
undetectable		 1vptA-3govB:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 3gov MASP-1
(Homo
sapiens) 		5 / 12 PRO A 360
THR A 344
VAL A 327
LEU A 304
SER A 356
 None
GOL  A   1 (-4.6A)
None
None
None
 1.46A 2fj1A-3govA:
undetectable		 2fj1A-3govA:
19.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 3gov MASP-1
(Homo
sapiens) 		5 / 6 ASP B 640
SER B 646
VAL B 666
GLY B 669
GLY B 679
 None
 0.43A 2otvA-3govB:
35.5		 2otvA-3govB:
35.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 3gov MASP-1
(Homo
sapiens) 		8 / 12 ASP B 640
ALA B 641
SER B 646
VAL B 666
TRP B 668
GLY B 669
GLY B 679
TYR B 681
 None
 0.45A 2p16A-3govB:
34.1		 2p16A-3govB:
32.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 3gov MASP-1
(Homo
sapiens) 		4 / 6 LEU A 304
TYR A 319
ILE A 347
ILE A 312
 None
 0.80A 2q8hA-3govA:
undetectable		 2q8hA-3govA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 3gov MASP-1
(Homo
sapiens) 		3 / 3 LEU B 573
PRO B 574
ARG B 693
 None
 0.56A 2qd5A-3govB:
undetectable		 2qd5A-3govB:
20.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 3gov MASP-1
(Homo
sapiens) 		5 / 8 ASP B 640
SER B 646
VAL B 666
GLY B 669
GLY B 679
 None
 0.64A 2vinA-3govB:
34.3		 2vinA-3govB:
30.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 3gov MASP-1
(Homo
sapiens) 		8 / 12 ASP B 640
ALA B 641
SER B 646
VAL B 666
TRP B 668
GLY B 669
GLY B 679
TYR B 681
 None
 0.42A 2w26A-3govB:
34.1		 2w26A-3govB:
32.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 3gov MASP-1
(Homo
sapiens) 		6 / 11 HIS B 490
ASP B 640
SER B 646
TRP B 668
GLY B 669
GLY B 679
 None
 0.48A 3gy3A-3govB:
34.7		 3gy3A-3govB:
35.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 3gov MASP-1
(Homo
sapiens) 		5 / 12 MET B 650
LEU B 662
GLY B 647
GLY B 648
TRP B 668
 None
 1.20A 3i5uA-3govB:
undetectable		 3i5uA-3govB:
20.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 3gov MASP-1
(Homo
sapiens) 		5 / 6 SER B 646
VAL B 666
TRP B 668
GLY B 669
GLY B 679
 None
 0.43A 3rxfA-3govB:
14.1		 3rxfA-3govB:
35.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 3gov MASP-1
(Homo
sapiens) 		4 / 5 ASP B 640
SER B 646
VAL B 666
GLY B 679
 None
 0.35A 3rxhA-3govB:
35.5		 3rxhA-3govB:
35.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 3gov MASP-1
(Homo
sapiens) 		5 / 12 THR B 460
PRO B 461
PRO B 649
ILE B 684
VAL B 486
 None
 1.06A 4eb6B-3govB:
undetectable
4eb6C-3govB:
undetectable		 4eb6B-3govB:
17.73
4eb6C-3govB:
19.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)		 3gov MASP-1
(Homo
sapiens) 		6 / 12 HIS B 490
ASP B 640
ALA B 641
VAL B 666
TRP B 668
GLY B 679
 None
 0.30A 4hfpD-3govB:
36.2		 4hfpD-3govB:
36.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 3gov MASP-1
(Homo
sapiens) 		3 / 3 ARG B 504
ASP B 545
ASP B 552
 None
 0.84A 4kicB-3govB:
undetectable		 4kicB-3govB:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3gov MASP-1
(Homo
sapiens) 		3 / 3 LEU B 573
PRO B 574
ARG B 693
 None
 0.54A 4klrB-3govB:
undetectable		 4klrB-3govB:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 3gov MASP-1
(Homo
sapiens) 		4 / 6 ALA B 641
ILE B 463
GLY B 648
VAL B 651
 None
 0.69A 4r21A-3govB:
undetectable		 4r21A-3govB:
19.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 3gov MASP-1
(Homo
sapiens) 		5 / 12 HIS B 490
ALA B 641
VAL B 666
TRP B 668
GLY B 669
 None
 0.85A 4rn6B-3govB:
30.1		 4rn6B-3govB:
36.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 3gov MASP-1
(Homo
sapiens) 		5 / 12 HIS B 490
VAL B 666
TRP B 668
GLY B 669
GLY B 679
 None
 0.44A 4rn6B-3govB:
30.1		 4rn6B-3govB:
36.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA810_1
(CATALASE-PEROXIDASE)		 3gov MASP-1
(Homo
sapiens) 		4 / 6 HIS A 375
LEU B 564
PRO B 562
SER B 483
 None
 1.36A 5syjA-3govA:
undetectable		 5syjA-3govA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB810_1
(CATALASE-PEROXIDASE)		 3gov MASP-1
(Homo
sapiens) 		4 / 6 HIS A 375
LEU B 564
PRO B 562
SER B 483
 None
 1.35A 5syjB-3govA:
undetectable		 5syjB-3govA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3gov MASP-1
(Homo
sapiens) 		4 / 4 LEU B 479
GLY B 481
SER B 483
SER B 561
 None
 1.31A 5uunB-3govB:
undetectable		 5uunB-3govB:
22.36