SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gpg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_A_ZPCA1318_2 (CYS-LOOP LIGAND-GATED ION CHANNEL)	3gpg	NON-STRUCTURAL PROTEIN 3 (Chikungunya virus)	4 / 7	VAL A 19 ILE A 11 ASN A 14 GLU A 43	None	1.03A	4a97E-3gpgA: undetectable	4a97E-3gpgA: 18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_C_ZPCC1318_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	3gpg	NON-STRUCTURAL PROTEIN 3 (Chikungunya virus)	5 / 12	VAL A 19 ILE A 11 ASN A 14 GLU A 43 VAL A 33	None	1.21A	4a97B-3gpgA: undetectable 4a97C-3gpgA: undetectable	4a97B-3gpgA: 18.24 4a97C-3gpgA: 18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_D_ZPCD1318_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	3gpg	NON-STRUCTURAL PROTEIN 3 (Chikungunya virus)	4 / 8	VAL A 19 ILE A 11 ASN A 14 GLU A 43	None	1.06A	4a97C-3gpgA: undetectable	4a97C-3gpgA: 18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WQ5_B_ACTB404_0 (TRNA N6-ADENOSINE THREONYLCARBAMOYLTRA NSFERASE)	3gpg	NON-STRUCTURAL PROTEIN 3 (Chikungunya virus)	3 / 3	TYR A 142 ARG A 5 LYS A 7	None	1.31A	4wq5B-3gpgA: undetectable	4wq5B-3gpgA: 20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FPD_A_PZAA1385_0 (HEAT SHOCK-RELATED 70KDA PROTEIN 2)	3gpg	NON-STRUCTURAL PROTEIN 3 (Chikungunya virus)	4 / 7	VAL A 104 SER A 103 ALA A 137 GLY A 100	None	0.92A	5fpdA-3gpgA: undetectable	5fpdA-3gpgA: 19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FPD_B_PZAB1385_0 (HEAT SHOCK-RELATED 70KDA PROTEIN 2)	3gpg	NON-STRUCTURAL PROTEIN 3 (Chikungunya virus)	5 / 7	VAL A 104 SER A 103 ALA A 137 GLY A 100 VAL A 96	None	1.33A	5fpdB-3gpgA: undetectable	5fpdB-3gpgA: 19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5I9Y_A_1N1A1001_2 (EPHRIN TYPE-A RECEPTOR 2)	3gpg	NON-STRUCTURAL PROTEIN 3 (Chikungunya virus)	3 / 3	ILE A 106 ILE A 152 MET A 132	None	0.71A	5i9yA-3gpgA: undetectable	5i9yA-3gpgA: 20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5OV9_A_CVIA608_0 (ACETYLCHOLINESTERASE)	3gpg	NON-STRUCTURAL PROTEIN 3 (Chikungunya virus)	4 / 7	THR A 122 LEU A 125 THR A 111 TYR A 89	None	1.10A	5ov9A-3gpgA: undetectable	5ov9A-3gpgA: 14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CK2_C_IPHC101_0 (INSULIN A CHAIN INSULIN B CHAIN)	3gpg	NON-STRUCTURAL PROTEIN 3 (Chikungunya virus)	4 / 4	ILE A 11 LEU A 109 HIS A 67 ALA A 68	None	1.02A	6ck2C-3gpgA: undetectable 6ck2D-3gpgA: undetectable	6ck2C-3gpgA: 7.89 6ck2D-3gpgA: 10.71

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4A97_A_ZPCA1318_2","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","3gpg","NON-STRUCTURAL PROTEIN 3","Chikungunya virus",4,"VAL A  19;ILE A  11;ASN A  14;GLU A  43","None","1.03A","4a97E-3gpgA:undetectable","4a97E-3gpgA:18.24"],["4A97_C_ZPCC1318_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","3gpg","NON-STRUCTURAL PROTEIN 3","Chikungunya virus",5,"VAL A  19;ILE A  11;ASN A  14;GLU A  43;VAL A  33","None","1.21A","4a97B-3gpgA:undetectable;4a97C-3gpgA:undetectable","4a97B-3gpgA:18.24;4a97C-3gpgA:18.24"],["4A97_D_ZPCD1318_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","3gpg","NON-STRUCTURAL PROTEIN 3","Chikungunya virus",4,"VAL A  19;ILE A  11;ASN A  14;GLU A  43","None","1.06A","4a97C-3gpgA:undetectable","4a97C-3gpgA:18.24"],["4WQ5_B_ACTB404_0","TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE","3gpg","NON-STRUCTURAL PROTEIN 3","Chikungunya virus",3,"TYR A 142;ARG A   5;LYS A   7","None","1.31A","4wq5B-3gpgA:undetectable","4wq5B-3gpgA:20.06"],["5FPD_A_PZAA1385_0","HEAT SHOCK-RELATED 70KDA PROTEIN 2","3gpg","NON-STRUCTURAL PROTEIN 3","Chikungunya virus",4,"VAL A 104;SER A 103;ALA A 137;GLY A 100","None","0.92A","5fpdA-3gpgA:undetectable","5fpdA-3gpgA:19.13"],["5FPD_B_PZAB1385_0","HEAT SHOCK-RELATED 70KDA PROTEIN 2","3gpg","NON-STRUCTURAL PROTEIN 3","Chikungunya virus",5,"VAL A 104;SER A 103;ALA A 137;GLY A 100;VAL A  96","None","1.33A","5fpdB-3gpgA:undetectable","5fpdB-3gpgA:19.13"],["5I9Y_A_1N1A1001_2","EPHRIN TYPE-A RECEPTOR 2","3gpg","NON-STRUCTURAL PROTEIN 3","Chikungunya virus",3,"ILE A 106;ILE A 152;MET A 132","None","0.71A","5i9yA-3gpgA:undetectable","5i9yA-3gpgA:20.48"],["5OV9_A_CVIA608_0","ACETYLCHOLINESTERASE","3gpg","NON-STRUCTURAL PROTEIN 3","Chikungunya virus",4,"THR A 122;LEU A 125;THR A 111;TYR A  89","None","1.10A","5ov9A-3gpgA:undetectable","5ov9A-3gpgA:14.60"],["6CK2_C_IPHC101_0","INSULIN A CHAIN;INSULIN B CHAIN","3gpg","NON-STRUCTURAL PROTEIN 3","Chikungunya virus",4,"ILE A  11;LEU A 109;HIS A  67;ALA A  68","None","1.02A","6ck2C-3gpgA:undetectable;6ck2D-3gpgA:undetectable","6ck2C-3gpgA:7.89;6ck2D-3gpgA:10.71"]]