SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gpi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_B_IU5B1002_1
(BILE ACID RECEPTOR)		 3gpi NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Methylobacillus
flagellatus) 		5 / 12 LEU A  16
ARG A 160
PHE A 152
ILE A 192
TYR A 257
 None
 1.10A 1ot7B-3gpiA:
undetectable		 1ot7B-3gpiA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 3gpi NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Methylobacillus
flagellatus) 		4 / 7 GLY A   8
GLN A  35
ARG A  32
VAL A  69
 None
 1.08A 1rxcF-3gpiA:
2.1		 1rxcF-3gpiA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 3gpi NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Methylobacillus
flagellatus) 		4 / 6 LEU A 141
ALA A 144
LEU A 142
SER A 147
 None
 1.31A 1tyrA-3gpiA:
undetectable		 1tyrA-3gpiA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 3gpi NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Methylobacillus
flagellatus) 		4 / 6 THR A 238
ALA A 237
ARG A 223
PRO A 217
 None
 1.35A 2ql8A-3gpiA:
undetectable
2ql8B-3gpiA:
undetectable		 2ql8A-3gpiA:
18.57
2ql8B-3gpiA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 3gpi NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Methylobacillus
flagellatus) 		4 / 6 GLY A   8
GLN A  35
ARG A  32
VAL A  69
 None
 1.07A 3kvvA-3gpiA:
2.7		 3kvvA-3gpiA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 3gpi NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Methylobacillus
flagellatus) 		4 / 6 GLY A   8
GLN A  35
ARG A  32
VAL A  69
 None
 1.08A 3kvvB-3gpiA:
3.3		 3kvvB-3gpiA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 3gpi NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Methylobacillus
flagellatus) 		4 / 6 GLY A   8
GLN A  35
ARG A  32
VAL A  69
 None
 1.08A 3kvvC-3gpiA:
2.8		 3kvvC-3gpiA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 3gpi NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Methylobacillus
flagellatus) 		4 / 6 GLY A   8
GLN A  35
ARG A  32
VAL A  69
 None
 1.13A 3kvvD-3gpiA:
3.3		 3kvvD-3gpiA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)		 3gpi NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Methylobacillus
flagellatus) 		4 / 6 GLY A   8
GLN A  35
ARG A  32
VAL A  69
 None
 1.09A 3kvvE-3gpiA:
undetectable		 3kvvE-3gpiA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 3gpi NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Methylobacillus
flagellatus) 		4 / 6 GLY A   8
GLN A  35
ARG A  32
VAL A  69
 None
 1.07A 3kvvF-3gpiA:
2.5		 3kvvF-3gpiA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 3gpi NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Methylobacillus
flagellatus) 		3 / 3 ASP A 227
ARG A 223
ALA A 226
 None
 0.68A 3mbgC-3gpiA:
undetectable		 3mbgC-3gpiA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3gpi NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Methylobacillus
flagellatus) 		4 / 5 SER A 266
ASP A 186
ASP A  11
ILE A 155
 None
 1.25A 3uj7B-3gpiA:
5.4		 3uj7B-3gpiA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 3gpi NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Methylobacillus
flagellatus) 		4 / 6 GLY A   8
GLN A  35
ARG A  32
VAL A  69
 None
 1.08A 4e1vF-3gpiA:
3.1		 4e1vF-3gpiA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 3gpi NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Methylobacillus
flagellatus) 		4 / 8 GLY A   8
GLN A  35
ARG A  32
VAL A  69
 None
 1.00A 4e1vG-3gpiA:
undetectable		 4e1vG-3gpiA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3gpi NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Methylobacillus
flagellatus) 		4 / 7 ARG A 160
SER A  75
GLY A  13
THR A  43
 None
 0.94A 5btaA-3gpiA:
undetectable
5btaC-3gpiA:
undetectable
5btaD-3gpiA:
2.7		 5btaA-3gpiA:
19.37
5btaC-3gpiA:
19.37
5btaD-3gpiA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 3gpi NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Methylobacillus
flagellatus) 		3 / 3 GLU A 116
TRP A 118
ASN A 244
 None
None
EDO  A 286 (-3.3A)
 1.16A 5dv4A-3gpiA:
undetectable		 5dv4A-3gpiA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 3gpi NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Methylobacillus
flagellatus) 		5 / 12 LEU A  94
ASN A  89
ALA A   7
VAL A 102
TYR A 145
 None
 1.30A 5kbwB-3gpiA:
undetectable		 5kbwB-3gpiA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 3gpi NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Methylobacillus
flagellatus) 		5 / 12 GLY A  29
ASP A  47
VAL A  48
THR A  49
VAL A  66
 None
 1.07A 5kocA-3gpiA:
undetectable		 5kocA-3gpiA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 3gpi NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Methylobacillus
flagellatus) 		6 / 12 GLY A   8
GLN A  35
ASP A  47
VAL A  48
THR A  49
ALA A  71
 None
 1.28A 5kpcB-3gpiA:
4.6		 5kpcB-3gpiA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 3gpi NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Methylobacillus
flagellatus) 		4 / 8 ASN A 249
ILE A 260
LEU A 252
PRO A 262
 None
 1.05A 5u4sB-3gpiA:
14.9		 5u4sB-3gpiA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3gpi NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Methylobacillus
flagellatus) 		4 / 7 ILE A   4
VAL A  66
PRO A  62
THR A 148
 None
 1.01A 6cduF-3gpiA:
undetectable
6cduG-3gpiA:
undetectable		 6cduF-3gpiA:
23.38
6cduG-3gpiA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 3gpi NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Methylobacillus
flagellatus) 		3 / 3 ARG A 185
ARG A 160
ASP A  11
 None
 0.93A 6d8pA-3gpiA:
3.2		 6d8pA-3gpiA:
17.62