SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gpu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQU_A_EQIA329_0
(PROTEIN (ESTRADIOL
17
BETA-DEHYDROGENASE
1))		 3gpu DNA GLYCOSYLASE
(Geobacillus
stearothermophil
us) 		5 / 10 SER A 158
VAL A 159
LEU A 163
GLY A 189
PRO A 188
 None
 1.13A 1equA-3gpuA:
undetectable		 1equA-3gpuA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 3gpu DNA GLYCOSYLASE
(Geobacillus
stearothermophil
us) 		5 / 12 SER A 158
VAL A 159
GLY A 189
PRO A 188
MET A 207
 None
 1.44A 1fdsA-3gpuA:
undetectable		 1fdsA-3gpuA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3gpu DNA GLYCOSYLASE
(Geobacillus
stearothermophil
us) 		4 / 7 PHE A 172
LEU A 195
PHE A 143
MET A 207
 None
 1.02A 1wrlE-3gpuA:
undetectable		 1wrlE-3gpuA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 3gpu DNA GLYCOSYLASE
(Geobacillus
stearothermophil
us) 		4 / 6 TYR A 240
THR A 210
GLU A 179
GLU A 213
 None
 1.43A 2dttB-3gpuA:
undetectable
2dttC-3gpuA:
undetectable		 2dttB-3gpuA:
18.22
2dttC-3gpuA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 3gpu DNA GLYCOSYLASE
(Geobacillus
stearothermophil
us) 		3 / 3 GLY A 115
ARG A  76
TYR A 108
 None
 0.86A 2opxA-3gpuA:
undetectable		 2opxA-3gpuA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 3gpu DNA GLYCOSYLASE
(Geobacillus
stearothermophil
us) 		4 / 6 GLY A 173
LEU A 163
GLU A   3
ASP A 178
 None
 0.94A 3ps9A-3gpuA:
undetectable		 3ps9A-3gpuA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3gpu DNA GLYCOSYLASE
(Geobacillus
stearothermophil
us) 		3 / 3 TYR A 268
GLU A 179
TYR A 240
 None
 0.95A 3ug8A-3gpuA:
undetectable		 3ug8A-3gpuA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 3gpu DNA GLYCOSYLASE
(Geobacillus
stearothermophil
us) 		3 / 3 ASP A 178
GLY A 265
TYR A 242
 None
 0.74A 3w9tC-3gpuA:
undetectable		 3w9tC-3gpuA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 3gpu DNA GLYCOSYLASE
(Geobacillus
stearothermophil
us) 		3 / 3 ASP A 178
GLY A 265
TYR A 242
 None
 0.75A 3w9tG-3gpuA:
undetectable		 3w9tG-3gpuA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 3gpu DNA GLYCOSYLASE
(Geobacillus
stearothermophil
us) 		4 / 6 PHE A  61
THR A 116
ARG A  76
GLY A  79
 None
 1.19A 5mraA-3gpuA:
1.7
5mraB-3gpuA:
undetectable		 5mraA-3gpuA:
20.23
5mraB-3gpuA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 3gpu DNA GLYCOSYLASE
(Geobacillus
stearothermophil
us) 		5 / 12 VAL A  26
PHE A  98
ILE A  23
LEU A  71
VAL A  96
 None
 0.97A 5uvmB-3gpuA:
undetectable		 5uvmB-3gpuA:
20.65