SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gqc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 3gqc DNA REPAIR PROTEIN
REV1
(Homo
sapiens) 		3 / 3 ARG A 516
TYR A 513
LYS A 625
 DCP  A 101 (-2.9A)
DCP  A 101 (-4.7A)
DCP  A 101 (-2.9A)
 1.00A 1uujB-3gqcA:
undetectable		 1uujB-3gqcA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 3gqc DNA REPAIR PROTEIN
REV1
(Homo
sapiens) 		5 / 11 GLY A 773
GLY A 772
TYR A 718
GLU A 466
PHE A 525
 None
 1.23A 1w76A-3gqcA:
undetectable		 1w76A-3gqcA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 3gqc DNA REPAIR PROTEIN
REV1
(Homo
sapiens) 		4 / 7 TYR A 353
GLU A 715
HIS A 820
GLY A 818
 None
 1.22A 2ha4B-3gqcA:
undetectable		 2ha4B-3gqcA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 3gqc DNA REPAIR PROTEIN
REV1
(Homo
sapiens) 		3 / 3 LEU A 649
PRO A 650
ARG A 693
 None
 0.44A 2qd4B-3gqcA:
undetectable		 2qd4B-3gqcA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 3gqc DNA REPAIR PROTEIN
REV1
(Homo
sapiens) 		3 / 3 LEU A 649
PRO A 650
ARG A 693
 None
 0.66A 2qd5A-3gqcA:
undetectable		 2qd5A-3gqcA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 3gqc DNA REPAIR PROTEIN
REV1
(Homo
sapiens) 		4 / 6 LEU A 573
GLU A 571
ALA A 566
THR A 369
 None
MG  A 202 (-3.8A)
None
None
 1.02A 2roxB-3gqcA:
undetectable		 2roxB-3gqcA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 3gqc DNA REPAIR PROTEIN
REV1
(Homo
sapiens) 		5 / 11 ILE A 610
PHE A 590
ALA A 591
GLU A 565
LEU A 557
 None
 1.42A 2v0mA-3gqcA:
undetectable		 2v0mA-3gqcA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 3gqc DNA REPAIR PROTEIN
REV1
(Homo
sapiens) 		5 / 12 MET A 803
GLY A 818
ILE A 739
SER A 713
HIS A 820
 None
 1.47A 3bwmA-3gqcA:
undetectable		 3bwmA-3gqcA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3gqc DNA REPAIR PROTEIN
REV1
(Homo
sapiens) 		5 / 12 GLY A 797
LEU A 743
VAL A 821
ILE A 819
LYS A 749
 None
 1.21A 3g9eA-3gqcA:
undetectable		 3g9eA-3gqcA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 3gqc DNA REPAIR PROTEIN
REV1
(Homo
sapiens) 		4 / 4 ILE A 419
ARG A 693
ILE A 614
THR A 577
 None
 1.16A 3ia4C-3gqcA:
undetectable		 3ia4C-3gqcA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 3gqc DNA REPAIR PROTEIN
REV1
(Homo
sapiens) 		3 / 3 ARG A 595
VAL A 549
THR A 602
 None
 0.84A 3k4vD-3gqcA:
undetectable		 3k4vD-3gqcA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 3gqc DNA REPAIR PROTEIN
REV1
(Homo
sapiens) 		3 / 3 HIS A 544
PHE A 428
PHE A 427
 None
DCP  A 101 (-3.8A)
None
 0.63A 3lk0D-3gqcA:
undetectable		 3lk0D-3gqcA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 3gqc DNA REPAIR PROTEIN
REV1
(Homo
sapiens) 		3 / 3 ARG A 595
VAL A 549
THR A 602
 None
 0.83A 3nduD-3gqcA:
undetectable		 3nduD-3gqcA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3gqc DNA REPAIR PROTEIN
REV1
(Homo
sapiens) 		4 / 6 PHE A 590
MET A 420
ILE A 579
ARG A 386
 None
 1.22A 4mk4B-3gqcA:
undetectable		 4mk4B-3gqcA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 3gqc DNA REPAIR PROTEIN
REV1
(Homo
sapiens) 		5 / 12 VAL A 446
VAL A 444
PHE A 428
SER A 430
GLY A 432
 None
None
DCP  A 101 (-3.8A)
None
None
 1.25A 4mm4B-3gqcA:
undetectable		 4mm4B-3gqcA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 3gqc DNA REPAIR PROTEIN
REV1
(Homo
sapiens) 		3 / 3 PRO A 463
ILE A 720
SER A 501
 None
 0.79A 5fsaA-3gqcA:
undetectable		 5fsaA-3gqcA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 3gqc DNA REPAIR PROTEIN
REV1
(Homo
sapiens) 		4 / 8 ILE A 564
MET A 420
ILE A 598
LEU A 375
 None
 1.01A 5ieoA-3gqcA:
undetectable		 5ieoA-3gqcA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 3gqc DNA REPAIR PROTEIN
REV1
(Homo
sapiens) 		4 / 7 GLY A 609
GLY A 611
SER A 612
LEU A 615
 None
 0.71A 5izfA-3gqcA:
undetectable		 5izfA-3gqcA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSA_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 3gqc DNA REPAIR PROTEIN
REV1
(Homo
sapiens) 		5 / 12 MET A 803
GLY A 818
ILE A 739
SER A 713
HIS A 820
 None
 1.47A 5lsaA-3gqcA:
undetectable		 5lsaA-3gqcA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3gqc DNA REPAIR PROTEIN
REV1
(Homo
sapiens) 		5 / 11 ASP A 345
ILE A 720
LEU A 735
SER A 736
VAL A 817
 None
 0.91A 5twjD-3gqcA:
undetectable		 5twjD-3gqcA:
15.77