SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3gqj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_1
(PROTEIN (HIV-1
PROTEASE))		 3gqj CELL INHIBITING
FACTOR (CIF)
(Photorhabdus
laumondii) 		5 / 10 LEU A 184
ASP A 275
ILE A 152
GLY A 150
VAL A 171
 None
 1.02A 1d4yA-3gqjA:
undetectable		 1d4yA-3gqjA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3gqj CELL INHIBITING
FACTOR (CIF)
(Photorhabdus
laumondii) 		5 / 11 LEU A 249
LEU A 254
ALA A 127
LEU A 230
ARG A 178
 None
 1.39A 1iiuA-3gqjA:
undetectable		 1iiuA-3gqjA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3gqj CELL INHIBITING
FACTOR (CIF)
(Photorhabdus
laumondii) 		5 / 11 LEU A 249
LEU A 254
ALA A 127
LEU A 230
ARG A 178
 None
 1.44A 1kt6A-3gqjA:
undetectable		 1kt6A-3gqjA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3gqj CELL INHIBITING
FACTOR (CIF)
(Photorhabdus
laumondii) 		5 / 11 LEU A 249
LEU A 254
ALA A 127
LEU A 230
ARG A 178
 None
 1.36A 1kt7A-3gqjA:
undetectable		 1kt7A-3gqjA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_1
(PROTEASE)		 3gqj CELL INHIBITING
FACTOR (CIF)
(Photorhabdus
laumondii) 		5 / 12 LEU A 184
ASP A 275
ILE A 152
GLY A 150
VAL A 171
 None
 0.93A 2nnkA-3gqjA:
undetectable		 2nnkA-3gqjA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 3gqj CELL INHIBITING
FACTOR (CIF)
(Photorhabdus
laumondii) 		4 / 6 ASP A 255
ILE A 250
LEU A 179
GLU A 264
 None
 0.99A 2ya7A-3gqjA:
undetectable		 2ya7A-3gqjA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 3gqj CELL INHIBITING
FACTOR (CIF)
(Photorhabdus
laumondii) 		4 / 6 ASP A 255
ILE A 250
LEU A 179
GLU A 264
 None
 0.99A 2ya7D-3gqjA:
undetectable		 2ya7D-3gqjA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 3gqj CELL INHIBITING
FACTOR (CIF)
(Photorhabdus
laumondii) 		5 / 12 ILE A 198
ILE A 185
ILE A 250
PHE A 183
VAL A 274
 None
 1.06A 2ygoA-3gqjA:
undetectable		 2ygoA-3gqjA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3gqj CELL INHIBITING
FACTOR (CIF)
(Photorhabdus
laumondii) 		5 / 12 LEU A 278
ALA A 172
VAL A 174
LEU A 208
LEU A 211
 None
 1.08A 3b0wB-3gqjA:
undetectable		 3b0wB-3gqjA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 3gqj CELL INHIBITING
FACTOR (CIF)
(Photorhabdus
laumondii) 		5 / 10 LEU A 278
SER A 160
ILE A 276
SER A 235
GLY A 154
 None
 1.14A 3ijxB-3gqjA:
undetectable
3ijxD-3gqjA:
undetectable		 3ijxB-3gqjA:
21.00
3ijxD-3gqjA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 3gqj CELL INHIBITING
FACTOR (CIF)
(Photorhabdus
laumondii) 		5 / 10 ILE A 276
SER A 235
GLY A 154
LEU A 278
SER A 160
 None
 1.25A 3ik6B-3gqjA:
undetectable
3ik6E-3gqjA:
undetectable		 3ik6B-3gqjA:
21.00
3ik6E-3gqjA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 3gqj CELL INHIBITING
FACTOR (CIF)
(Photorhabdus
laumondii) 		5 / 10 LEU A 278
SER A 160
ILE A 276
SER A 235
GLY A 154
 None
 1.26A 3ik6B-3gqjA:
undetectable
3ik6E-3gqjA:
undetectable		 3ik6B-3gqjA:
21.00
3ik6E-3gqjA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 3gqj CELL INHIBITING
FACTOR (CIF)
(Photorhabdus
laumondii) 		5 / 10 LEU A 278
SER A 160
ILE A 276
SER A 235
GLY A 154
 None
 1.28A 3iluB-3gqjA:
undetectable
3iluE-3gqjA:
undetectable		 3iluB-3gqjA:
21.00
3iluE-3gqjA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 3gqj CELL INHIBITING
FACTOR (CIF)
(Photorhabdus
laumondii) 		5 / 11 ILE A 276
SER A 235
GLY A 154
LEU A 278
SER A 160
 None
 1.22A 3iluB-3gqjA:
undetectable
3iluE-3gqjA:
undetectable		 3iluB-3gqjA:
21.00
3iluE-3gqjA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3gqj CELL INHIBITING
FACTOR (CIF)
(Photorhabdus
laumondii) 		5 / 12 ILE A 185
ALA A 172
LEU A 173
ILE A 290
ILE A  82
 None
 1.03A 3mb5A-3gqjA:
undetectable		 3mb5A-3gqjA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 3gqj CELL INHIBITING
FACTOR (CIF)
(Photorhabdus
laumondii) 		5 / 10 LEU A 184
ASP A 275
ILE A 152
GLY A 150
VAL A 171
 None
 0.98A 3oxwC-3gqjA:
undetectable		 3oxwC-3gqjA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 3gqj CELL INHIBITING
FACTOR (CIF)
(Photorhabdus
laumondii) 		3 / 3 GLU A 280
TYR A 170
SER A 165
 None
 0.79A 4at0A-3gqjA:
undetectable		 4at0A-3gqjA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3gqj CELL INHIBITING
FACTOR (CIF)
(Photorhabdus
laumondii) 		5 / 12 LEU A 184
ILE A 213
LEU A 217
ILE A  60
THR A 135
 None
 1.02A 4x5gB-3gqjA:
undetectable		 4x5gB-3gqjA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 3gqj CELL INHIBITING
FACTOR (CIF)
(Photorhabdus
laumondii) 		4 / 8 GLN A 128
GLN A 200
SER A 201
HIS A 181
 None
None
GOL  A 310 ( 4.2A)
None
 1.01A 5km8A-3gqjA:
undetectable
5km8B-3gqjA:
undetectable		 5km8A-3gqjA:
19.08
5km8B-3gqjA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 3gqj CELL INHIBITING
FACTOR (CIF)
(Photorhabdus
laumondii) 		4 / 5 GLY A 180
ASP A 176
ARG A 177
GLN A 128
 None
 1.34A 5zrfB-3gqjA:
undetectable		 5zrfB-3gqjA:
15.68